N6-Methyladenosine Modification in the Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Open Access
Satoru Matsuda,

Moeka Nakashima,

Akari Fukumoto

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1158 - 1158

Published: March 27, 2025

Epigenetics of N6-methyladenine (m6A) modification may play a key role during the regulation various diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The m6A has been shown to be accomplished via exploitation several players such as methyltransferases, demethylases, and/or methylation-binding molecules. Significantly, methylation can regulate eukaryotic transcriptome by affecting subcellular localization, splicing, export, stability, translation, and decay those RNAs. An increasing amount data designated that RNAs also modulate expression autophagy-related genes, which could control autophagy in hepatocytes. Oxidative stress with reactive oxygen species (ROS) induce RNA methylation, might associated mitochondrial (mitophagy) development MASLD. Therefore, both important roles regulating pathogenesis Comprehending relationship between mitophagy helpful for future therapeutic strategies against This review would advance understanding regulatory mechanisms modification, focusing on impact dysregulation

Language: Английский

N6-Methyladenosine Modification in the Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Open Access
Satoru Matsuda,

Moeka Nakashima,

Akari Fukumoto

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1158 - 1158

Published: March 27, 2025

Epigenetics of N6-methyladenine (m6A) modification may play a key role during the regulation various diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). The m6A has been shown to be accomplished via exploitation several players such as methyltransferases, demethylases, and/or methylation-binding molecules. Significantly, methylation can regulate eukaryotic transcriptome by affecting subcellular localization, splicing, export, stability, translation, and decay those RNAs. An increasing amount data designated that RNAs also modulate expression autophagy-related genes, which could control autophagy in hepatocytes. Oxidative stress with reactive oxygen species (ROS) induce RNA methylation, might associated mitochondrial (mitophagy) development MASLD. Therefore, both important roles regulating pathogenesis Comprehending relationship between mitophagy helpful for future therapeutic strategies against This review would advance understanding regulatory mechanisms modification, focusing on impact dysregulation

Language: Английский

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