The Effect of Melatonin on Sleep Quality and Daytime Sleepiness in Parkinson’s Disease: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Azzam Zrineh,
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Rami Akwan,
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Marwa Elsharkawy
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et al.
Sleep Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106540 - 106540
Published: April 1, 2025
Language: Английский
The role of melatonin in the regulation of the immune system and reproductive health: mechanisms and prospects for clinical application
Ukrainian Journal of Veterinary and Agricultural Sciences,
Journal Year:
2025,
Volume and Issue:
8(1), P. 49 - 61
Published: April 23, 2025
Melatonin
is
a
multifunctional
hormone
with
diverse
physiological
roles,
particularly
in
immune
regulation
and
reproductive
health.
While
primarily
synthesized
by
the
pineal
gland
response
to
circadian
rhythm,
melatonin
also
produced
extrapineal
tissues
such
as
placenta,
gastrointestinal
tract,
organs,
highlighting
its
systemic
significance.
Beyond
role
sleep-wake
cycle
regulation,
exhibits
potent
antioxidant,
anti-inflammatory,
immunomodulatory
properties,
making
it
essential
for
maintaining
cellular
homeostasis
overall
stability.
In
system,
contributes
both
innate
adaptive
immunity
modulating
cytokine
production,
reducing
oxidative
stress,
enhancing
cell
activity.
It
plays
protective
against
infections
inflammatory
diseases
suppressing
pro-inflammatory
mediators
interleukin-6
(IL-6)
tumor
necrosis
factor-alpha
(TNF-α)
while
promoting
anti-inflammatory
cytokines
like
interleukin-10
(IL-10).
Additionally,
influences
tolerance,
which
critical
preventing
autoimmune
responses
ensuring
successful
pregnancy.
females,
improves
oocyte
quality,
embryo
development,
pregnancy
outcomes
protecting
ovarian
follicles
from
damage,
regulating
steroidogenesis,
supporting
placental
function.
Its
fetal
development
significant,
maternal-fetal
signaling,
vascularization,
epigenetic
modifications
that
influence
gene
expression.
men,
spermatogenesis
sperm
quality
boosting
mitochondrial
activity,
decreasing
safeguarding
DNA
damage.
helps
regulate
production
testes,
optimal
Given
pleiotropic
effects,
holds
substantial
therapeutic
potential
addressing
dysfunction,
disorders,
complications.
Future
research
should
focus
on
clinical
applications
of
supplementation
treating
infertility,
pregnancy-related
complications,
immune-mediated
diseases.
Understanding
intricate
relationship
between
melatonin,
immunity,
reproduction
may
pave
way
innovative
strategies
human
veterinary
medicine.
roles
well-known
function
rhythm
exerts
effects.
function,
thereby
offering
protection
disorders.
reproduction,
key
processes
maturation,
maintenance.
supports
fertility
improving
gonadotropin
secretion,
melatonin's
involvement
highlights
significance
gestation.
widespread
presents
promising
immune-related
exploring
lead
novel
success
resilience
Language: Английский
Melatonin from Plants: Going Beyond Traditional Central Nervous System Targeting—A Comprehensive Review of Its Unusual Health Benefits
Biology,
Journal Year:
2025,
Volume and Issue:
14(2), P. 143 - 143
Published: Jan. 30, 2025
Melatonin
is
indispensable
for
the
homeostasis
of
plants
and
animals.
In
humans,
it
can
help
prevent
or
be
an
adjuvant
treatment
several
diseases
mainly
related
to
immune
system,
inflammation,
oxidative
stress.
Moreover,
a
melatonin-rich
diet
linked
health
benefits,
such
as
regulation
circadian
rhythm,
immunological
epilepsy
control,
delaying
aging
process,
diminishing
hormones
cancer.
This
review
aimed
show
effects
melatonin
in
beyond
its
traditional
use.
The
results
showed
present
scavenging
free
radicals,
reducing
inflammatory
cytokines,
modulating
system.
improve
insulin
resistance,
blood
pressure,
LDL-c,
adipose
tissue
mass,
adhesion
molecules,
endothelial
impairment,
plaque
formation.
These
result
neuro-
cardioprotection,
improvement
liver
diseases,
rheumatoid
arthritis,
dermatitis,
COVID-19,
polycystic
ovaries,
sepsis.
We
conclude
that
plant
benefit
patients
with
many
besides
sleep
problems
neurodegeneration.
Plant
may
more
cost-effective
fewer
adverse
events
than
synthetic.
However,
clinical
trials
should
performed
adequate
doses,
formulation,
time.
Language: Английский
Melatonin augments anti-tumor activity and alleviates nephrotoxicity of gemcitabine in a pancreatic cancer xenograft model targeting P62/Keap1 pathway
Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Abstract
Although
gemcitabine
is
a
primary
chemotherapy
for
pancreatic
cancer,
its
effectiveness
limited
by
chemoresistance
and
nephrotoxicity,
posing
significant
clinical
challenges.
Therefore,
the
development
of
novel
therapeutic
approaches
to
prevent
malignancy
remains
crucial.
This
study
aimed
investigate
potential
melatonin
in
enhancing
gemcitabine’s
anticancer
efficacy
while
mitigating
nephrotoxic
effects
through
modulation
Keap1/p62
pathway.
A
cancer
xenograft
model
was
established
rats,
which
received
either
(50
mg/kg,
I.P.),
or
their
combination
three
times
per
week
2
weeks.
Our
findings
demonstrate
that
potentiates
cancer-suppressing
via
Kelch-like-ECH
associated
protein-1
(Keap1)/p62
pathway,
resulting
reduced
fibrosis,
oxidative
stress,
inflammatory
markers.
Additionally,
significantly
mitigated
gemcitabine-induced
nephrotoxicity.
These
results
suggest
may
serve
as
an
adjuvant
therapy
treatment,
reducing
adverse
effects.
Language: Английский