Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3447 - 3447
Published: May 26, 2022
Tetrachlorinated
phthalimide
analogues
bearing
a
boron-pinacolate
ester
group
were
synthesised
via
two
synthetic
routes
and
evaluated
in
their
glycosidase
modulating
anticancer
properties,
with
view
to
use
them
boron
neutron
capture
therapy
(BNCT),
promising
radiation
type
for
cancer,
as
this
does
little
damage
biological
tissue.
An
unexpected
decarbonylation/decarboxylation
five
2,3,4,5-tetrachlorobenzamides
was
observed
confirmed
by
X-ray
crystallography
studies,
thus,
giving
access
family
of
borylated
2,3,4,5-tetrachlorobenzamides.
Biological
evaluation
showed
the
benzamide
drugs
possess
good
weak
potencies
(74.7–870
μM)
inhibition
glycosidases,
have
moderate
selectivity
panel
18
glycosidases.
Furthermore,
selected
there
is
core
subset
three
animal
which
always
inhibited
(rat
intestinal
maltase
α-glucosidase,
bovine
liver
β-glucosidase
β-galactosidase).
This
could
indicate
involvement
atom
binding.
These
glycosidases
are
targeted
management
diabetes,
viral
infections
(via
broad-spectrum
approach)
lysosomal
storage
disorders.
Assays
against
cancer
cell
lines
revealed
potency
growth
molecules,
one
these
normal
line
MCF10A
not
being
affected
compound.
One
molecules
both
selectivity;
it
candidate
further
study
area.
paper
provides
numerous
novel
aspects,
including
expedited
2,3,4,5-tetrachlorophthalimides
The
latter
constitutes
drugs.
greener
such
structures
described.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(5), P. 2441 - 2511
Published: Feb. 21, 2024
Boron-containing
compounds
(BCC)
have
emerged
as
important
pharmacophores.
To
date,
five
BCC
drugs
(including
boronic
acids
and
boroles)
been
approved
by
the
FDA
for
treatment
of
cancer,
infections,
atopic
dermatitis,
while
some
natural
are
included
in
dietary
supplements.
Boron's
Lewis
acidity
facilitates
a
mechanism
action
via
formation
reversible
covalent
bonds
within
active
site
target
proteins.
Boron
has
also
employed
development
fluorophores,
such
BODIPY
imaging,
carboranes
that
potential
neutron
capture
therapy
agents
well
novel
diagnostics
therapy.
The
utility
synthetic
become
multifaceted,
breadth
their
applications
continues
to
expand.
This
review
covers
many
uses
targets
boron
medicinal
chemistry.
Frontiers in Plant Science,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 12, 2024
Boron
(B)
is
an
essential
microelement
for
plants,
and
its
deficiency
can
lead
to
impaired
development
function.
Around
50%
of
arable
land
in
the
world
acidic,
low
pH
soil
solution
decreases
availability
several
mineral
elements,
including
B,
magnesium
(Mg),
calcium
(Ca),
potassium
(K).
Plants
take
up
B
form
boric
acid
(H
3
BO
)
acidic
or
tetrahydroxy
borate
[B(OH)
4
]
-
at
neutral
alkaline
pH.
participate
directly
indirectly
plant
metabolism,
synthesis
cell
wall
plasma
membrane,
carbohydrate
protein
formation
ribonucleic
(RNA).
In
addition,
interacts
with
other
nutrients
such
as
Ca,
nitrogen
(N),
phosphorus
(P),
K,
zinc
(Zn).
this
review,
we
discuss
mechanisms
uptake,
translocation,
accumulation
interactions
how
it
contributes
adaptation
plants
different
environmental
conditions.
We
also
potential
B-mediated
networks
physiological
molecular
levels
involved
growth
development.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(16), P. 9147 - 9147
Published: Aug. 15, 2022
Boron
(B)
is
considered
a
prebiotic
chemical
element
with
role
in
both
the
origin
and
evolution
of
life,
as
well
an
essential
micronutrient
for
some
bacteria,
plants,
fungi,
algae.
B
has
beneficial
effects
on
biological
functions
humans
animals,
such
reproduction,
growth,
calcium
metabolism,
bone
formation,
energy
immunity,
brain
function.
Naturally
organic
(NOB)
species
may
become
promising
novel
candidates.
NOB-containing
compounds
have
been
shown
to
be
symbiosis
between
organisms
from
different
kingdoms.
New
insights
into
key
NOB
human/animal
hosts
their
microbiota
will
influence
use
natural
B-based
colon-targeting
nutraceuticals.
The
mechanism
action
(MoA)
related
signaling
molecule
(autoinducer-2-borate
(AI-2B))
fortification
colonic
mucus
gel
layer
B-rich
diets.
Both
can
targets.
This
paper
reviews
evidence
supporting
essentiality
hosts,
stated
aim
highlighting
MoA
targets
these
species.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 528 - 528
Published: Feb. 20, 2023
Pea
plants
are
sensitive
to
water
shortages,
making
them
less
attractive
farmers.
Hoping
reduce
the
adverse
effects
of
drought
on
peas
and
considering
benefits
boron,
this
study
aimed
investigate
impact
boron
nanoparticles
antioxidant
system
oxidative
stress
biomarkers
in
drought-stressed
peas.
Experiments
were
performed
a
greenhouse.
treated
with
suspension
B2O3
at
12.5,
25,
50
ppm
concentrations
before
ten
days
shortage.
Drought
induced
by
maintaining
30%
substrate
moisture.
This
investigated
properties
nanoparticle
different
application
methods
for
spraying
watering
pea
plants.
The
determined
growth
indicators,
biomarkers,
enzymatic
non-enzymatic
antioxidants.
Spraying
12.5
most
effectively
stimulated
phenol
accumulation;
FRAP,
DPPH,
ABTS
capacity;
APX,
SOD,
GPX,
CAT
enzyme
activity
leaves
exposed
drought.
In
addition,
reduced
amount
MDA
H2O2
grown
insufficient
substantial
positive
effect
was
found
affected
after
nanoparticles.
positively
height,
leaf
area,
number
nodules,
yield.
Plants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 777 - 777
Published: Feb. 9, 2023
On
the
eve
of
100th
anniversary
Dr.
Warington’s
discovery
boron
(B)
as
a
nutrient
essential
for
higher
plants,
“boronists”
have
struggled
to
demonstrate
role
beyond
its
structural
function
in
cell
walls
dimerizing
pectin
molecules
rhamnogalacturonan
II
(RGII).
In
this
regard,
B
deficiency
has
been
associated
with
plethora
symptoms
plants
that
include
macroscopic
like
growth
arrest
and
death
biochemical
or
molecular
changes
wall
pore
size,
apoplast
acidification,
steep
ROS
production
leads
an
oxidative
burst.
Aiming
shed
light
on
functions
plant
biology,
we
proposed
here
unifying
model
integrating
current
knowledge
about
function(s)
explain
why
can
cause
such
remarkable
effects
development,
impacting
crop
productivity.
addition,
based
recent
experimental
evidence
suggests
existence
different
ligands
other
than
RGII
cells,
namely
glycolipids,
glycoproteins,
pipeline
identify
putative
missing
determine
how
they
would
integrate
into
above-mentioned
model.
Journal of Agronomy and Crop Science,
Journal Year:
2025,
Volume and Issue:
211(2)
Published: March 1, 2025
ABSTRACT
The
study
aimed
to
determine
how
the
physiological
responses
of
sunflower
(
Helianthus
annuus
L.)
plant
were
affected
by
prolonged
drought
stress,
salinity
and
boron
application,
as
well
assess
recovery
dynamics
following
re‐watering.
experimental
design
included
well‐watered
(WW
80%
watering),
stress
(DS,
20%
watering)
(SS,
0
control
13
dS
m
−1
),
toxicity
(Na
2
O
5
B
3
.10H
O,
at
different
doses
8
mg
L
)
re‐watering
after
a
long‐term
period
(24
days).
well‐irrigated
(80%
WW)
treatment,
which
all
factors
non‐stressed
treatment
during
experiment
was
carried
out
with
five
replications.
Morphological,
biochemical
analyses
plants
measured
four
time
points:
10th
24th
days
onset
re‐watering,
2nd
7th
following.
relative
membrane
permeability
increased
water
content
decreased
because
limited
availability
caused
an
imbalance
in
status
leaves
stem
plant.
Even
though
high
levels
Na
+
Cl
−
ions
interfered
essential
nutrient
uptake
under
Ca
+2
ion
significantly
areas
treated
drought,
salt,
Extended
or
intense
conditions
harmed
phloem
xylem
tissue
cells
changing
cell
size
density,
turn
disrupted
processes,
including
functioning
channels
challenging
circumstances.
Particularly
salt
vascular
bundles
observed
either
shrink
assume
irregular
shape.
Long‐term
reduced
(RWC)
values,
resulting
dehydration
osmotic
pressure
(RMP)
leaf
cells,
further
exacerbated
stress.
attempted
regain
some
its
characteristics
response
these
severe
However,
24
long
dry
period,
even
if
watering
re‐applied,
growth
power
due
disturbance
result
excessive
damage.
