SPPiDDRs: a new gene family in dicot plants involved in DNA-Damage Response DOI Creative Commons
Valentin Hammoudi,

Elisa Goldbecker,

Josephine Herbst

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 21, 2023

ABSTRACT Living organisms must maintain the integrity of their genome, and plants are not exempt. In plants, recognition DNA damage converges at transcription factor SOG1, a functional homolog animal p53 protein. SOG1 directly controls expression hundreds genes orchestrates sophisticated network signaling pathways termed DNA-damage response (DDR). Only recently, several long non-coding RNA (lncRNA) loci were identified to be upregulated by damage, only handful have been confirmed actively contribute DDR. this study, we focused on one locus annotated as lncRNA found that it is strongly quickly upon direct target SOG1. Combining in silico experimental analyses, demonstrate was wrongly fact gene coding for short protein targets peroxisomes. Consequently, renamed S HORT P EROXISOMAL ROTEIN INDUCED IN D NA- AMAGE R ESPONSE1 ( SPPiDDR1 ). SPPiDDRs well conserved present multiple copies across dicot genomes, with Arabidopsis containing two additional copies, SPPiDDR2 SPPiDDR3 . The AtSPPiDDR paralogs differ transcriptional level, being least active. both also induced salt, stress treatment known indirectly induce via oxidative stress. We show these act redundantly inhibit plant growth salt

Language: Английский

SPPiDDRs: a new gene family in dicot plants involved in DNA-Damage Response DOI Creative Commons
Valentin Hammoudi,

Elisa Goldbecker,

Josephine Herbst

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 21, 2023

ABSTRACT Living organisms must maintain the integrity of their genome, and plants are not exempt. In plants, recognition DNA damage converges at transcription factor SOG1, a functional homolog animal p53 protein. SOG1 directly controls expression hundreds genes orchestrates sophisticated network signaling pathways termed DNA-damage response (DDR). Only recently, several long non-coding RNA (lncRNA) loci were identified to be upregulated by damage, only handful have been confirmed actively contribute DDR. this study, we focused on one locus annotated as lncRNA found that it is strongly quickly upon direct target SOG1. Combining in silico experimental analyses, demonstrate was wrongly fact gene coding for short protein targets peroxisomes. Consequently, renamed S HORT P EROXISOMAL ROTEIN INDUCED IN D NA- AMAGE R ESPONSE1 ( SPPiDDR1 ). SPPiDDRs well conserved present multiple copies across dicot genomes, with Arabidopsis containing two additional copies, SPPiDDR2 SPPiDDR3 . The AtSPPiDDR paralogs differ transcriptional level, being least active. both also induced salt, stress treatment known indirectly induce via oxidative stress. We show these act redundantly inhibit plant growth salt

Language: Английский

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