Springer protocols handbooks/Springer protocols, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 115
Published: Jan. 1, 2024
Language: Английский
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: May 27, 2024
Plant-microbe interactions are pivotal for ecosystem dynamics and sustainable agriculture, influenced by various factors, such as host characteristics, environmental conditions, human activities. Omics technologies, including genomics, transcriptomics, proteomics, metabolomics, have revolutionized our understanding of these interactions. Genomics elucidates key genes, transcriptomics reveals gene expression dynamics, proteomics identifies essential proteins, metabolomics profiles small molecules, thereby offering a holistic perspective. This review synthesizes diverse microbial-plant interactions, showcasing the application omics in mechanisms, nitrogen fixation, systemic resistance induction, mycorrhizal association, pathogen-host Despite challenges data integration ethical considerations, approaches promise advancements precision intervention resilient agricultural practices. Future research should address challenges, enhance technology resolution, explore epigenomics, understand plant-microbe under conditions. In conclusion, technologies hold immense optimizing strategies fortifying alliances, paving way agriculture stewardship.
Language: Английский
Citations
24
Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 5, 2025
Abstract Endophytic fungi represent a significant renewable resource for the discovery of pharmaceutically important compounds, offering substantial potential new drug development. Their ability to address growing issue resistance has drawn attention from researchers seeking novel, nature-derived lead molecules that can be produced on large scale meet global demand. Recent advancements in genomics, metabolomics, bioinformatics, and improved cultivation techniques have significantly aided identification characterization fungal endophytes their metabolites. Current estimates suggest there are approximately 1.20 million globally, yet only around 16% (190,000) been identified studied detail. This underscores vast untapped pharmaceutical research. Research increasingly focused transformation bioactive compounds by through chemical enzymatic processes. A notable example is anthraquinone derivative 6-O-methylalaternin, whose cytotoxic enhanced addition hydroxyl group, sharing structural similarities with its parent compound macrosporin. These structure-bioactivity studies open up avenues developing safer more effective therapeutic agents synthesizing targeted derivatives. Despite immense promise, challenges remain, particularly large-scale understanding complexities biosynthetic pathways. Additionally, genetic manipulation optimized metabolite production still infancy. Future research should aim overcome these limitations focusing efficient methods deeper exploration endophytes’ metabolic capabilities fully harness potential. Graphical
Language: Английский
Citations
7
Critical Reviews in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19
Published: Jan. 6, 2025
This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects various physiological processes, potential toxicity, safety considerations, in order unlock full applications. Dendrobine has diverse effects, anti-inflammatory, antioxidant, neuroprotective, immunomodulatory, anticancer effects. also exerts neuroprotective by boosting neuronal survival, reducing neuroinflammation, regulating neurotransmitter release. immunomodulatory that control immune cell function modify immunological responses. exhibits properties decreasing tumor angiogenesis metastasis, causing apoptosis cancer cells, inhibiting growth. discusses idea a circular economy produce researching cutting-edge sustainable methods maximize resource efficiency reduce environmental Additionally, supporting principles for production outlining future study areas, this discovery will help use dendrobine variety applications while preserving environment. Future research should focus advancing application personalized medicine, exploring green bioproduction methods, ensuring ethical sourcing practices. An enhanced understanding synergistic therapies could revolutionize healthcare, whereas conservation efforts safeguard ecological impact.
Language: Английский
Citations
1
Plant Disease, Journal Year: 2024, Volume and Issue: 108(6), P. 1894 - 1894
Published: April 8, 2024
Dendrobium nobile is the largest species of Orchidaceae family and produces dendrobine, a compound with medicinal properties (Sarsaiya et al., 2020a; Sarsaiya 2024; Qian 2024). The accumulation dendrobine in D. regulated by various pathogenic fungi, which directly indirectly influence biosynthesis 2019a; 2019b). In field planted Guizhou Province, China, small lesions were initially observed on upper part leaves from May to June 2019, later developed into larger brown necrotic leaf lesions. Over time, these greatly impacted value (dendrobine) productivity plant. A pure culture Xylaria flabelliformis infected wild was recovered subsequently cultured potato dextrose agar (PDA) at 25 °C for 5 days. grew slowly composed white mycelia. Colonies white, regular margin, formed stromata that consisted mycelia sterilia without ascospores. We identified strain as based its morphological characteristics (Liu 2007) sequencing elongation factor-1α (EF-1α). length DNA sequence EF-1α used analysis 1188 bp. BLASTx (nucleotide 6-frame translation-protein) using National Center Biotechnology Information database showed obtained protein (BLASTx accession no.: UTS95822.1, BLASTn nucleotide MW508334.1) had highest similarity (98.21%) X. hypothetical (TRX95197.1) thorough phylogenetic comparison other species. Healthy seedlings pots sterilized. terminal excised all pre-sterilised inoculated mycelial plugs, whereas sterile PDA plugs moist cotton controls. All maintained under optimum temperature humidity conditions (25 80%, respectively) seven days observation analysis. experiments performed triplicate. After incubation period, rot first time leaves, but no symptoms two control groups (sterile plugs). To complete Koch's postulates, re-isolated diseased tissues EF-1α. It determined can cause nobile. Moreover, pathogenicity has not been previously reported (Mead 2019; Meng 2020b; Chen 2023; Rinchen, Cao best our knowledge, this report BLRS caused China. Identification pathogen crucial advancing effective management practices against disease. This discovery provides valuable insights development targeted strategies mitigate impact nobile, safeguard such enhance overall productivity.
Language: Английский
Citations
4
Molecules, Journal Year: 2024, Volume and Issue: 29(16), P. 3787 - 3787
Published: Aug. 10, 2024
Dendrobium species, which are perennial herbs widely distributed in tropical and subtropical regions, notable for their therapeutic properties attributed to various bioactive compounds, including dendrobine-type sesquiterpenoid alkaloids (DTSAs). The objective of this review article is provide a comprehensive overview recent advances the biosynthesis DTSAs, extraction from species endophytes, elucidation associated genes through genomic transcriptomic sequencing both spp. exploration biosynthetic pathways drawing conclusions outlining future perspectives field. Alkaloids, predominantly nitrogen-containing compounds found medicinal orchids, include over 140 types discovered across more than 50 species. identified 37 picrotoxane alkaloids, have distinctive five-membered nitrogen heterocyclic ring. This highlights endophytic fungi as alternative sources emphasizing potential pharmaceutical applications when plant-derived scarce or complex. Genomic endophytes has key involved DTSAs biosynthesis, elucidating such mevalonate (MVA) 2-C-methyl-D-erythritol 4-phosphate (MEP) pathways. Genes encoding enzymes, acetyl-CoA C-acetyltransferase diphosphomevalonate decarboxylase, positively with dendrobine production. Despite significant advancements, complexity terpenoid different subcellular compartments remains challenge. Future research should focus on leveraging high-quality data omics technologies further understand manipulate enhance use.
Language: Английский
Citations
3
Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 255, P. 116663 - 116663
Published: Jan. 5, 2025
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 29, 2025
The rhizosphere microbiome plays a critical role in plant health and productivity by fostering beneficial microbial interactions that support nutrient cycling, stress tolerance, disease suppression. In the context of Dendrobium , understanding its is essential for optimizing cultivation promoting sustainable agricultural practices. This review explores focusing on mechanisms contribute to health, growth their implications agriculture. study highlights diverse composition communities rhizosphere, including key bacteria (e.g., Pseudomonas fluorescens Bacillus subtilis ), fungi Glomus spp.), biocontrol agents ( Trichoderma discusses roles suppression, promotion. emphasizes significance plant-microbe signaling, such as production flavonoids, phytohormones, strigolactones, shaping environment enhancing resilience. Additionally, it addresses modern techniques analyzing communities, metagenomics next-generation sequencing, applications advancing precision Future research should focus bridging knowledge gaps related genotype-microbiome interactions, exploring emerging consortia integration management agriculture systems improve productivity.
Language: Английский
Citations
0
CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 255 - 272
Published: March 24, 2025
Language: Английский
Citations
0
Current Opinion in Plant Biology, Journal Year: 2024, Volume and Issue: 82, P. 102620 - 102620
Published: Sept. 5, 2024
Language: Английский
Citations
2
Natural Product Communications, Journal Year: 2024, Volume and Issue: 19(11)
Published: Nov. 1, 2024
Dendrobium nobile ( D. nobile), an orchid species deeply rooted in traditional medicine, has garnered considerable attention for its potential pharmacological and therapeutic properties. This critical review provides a comprehensive analysis of the bioactive compounds present explores their diverse effects. The phytochemistry been discussed, highlighting major constituents with specific profile investigated various domains. Notably, strong antioxidant activity ability to scavenge free radicals have shown support immune-modulating, anti-inflammatory, neuroprotective Intriguingly, these orchids display promising anticancer, antidiabetic, cardiovascular, renoprotective, hepatoprotective, wound-healing mechanisms underlying effects were explored, including molecular pathways signalling cascades. However, factors influencing chemical composition, such as environmental conditions, cultivation techniques, postharvest processing, must be considered consistent outcomes. safety toxicity profiles derived from acute chronic studies examined. In future studies, exploring untapped elucidating intricate action are promising. underscores richness nobile, revealing contribute modern medicine while emphasising need further investigation harness full benefits.
Language: Английский
Citations
2