The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats DOI Open Access
Marko Gerić, Lucia Nanić, Vedran Micek

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1187 - 1187

Published: March 28, 2025

Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate potential geroprotective effects of resveratrol and melatonin rats. The animals were treated with these two compounds starting at 3 months age continuing until 1 year or 2 years age. Using a multibiomarker approach, assessed DNA damage, telomere length, oxidative status their urine, liver, kidneys. Despite employing this experimental our results did not provide conclusive evidence across evaluated organs. However, observed sex-dependent differences response treatment. high potency compounds, further research is warranted explore incorporation into daily routines as strategy mitigate ageing-related effects.

Language: Английский

The Impact of Resveratrol and Melatonin on the Genome and Oxidative Status in Ageing Rats DOI Open Access
Marko Gerić, Lucia Nanić, Vedran Micek

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1187 - 1187

Published: March 28, 2025

Given the growing challenges posed by an ageing population, particularly in Western countries, we aimed to investigate potential geroprotective effects of resveratrol and melatonin rats. The animals were treated with these two compounds starting at 3 months age continuing until 1 year or 2 years age. Using a multibiomarker approach, assessed DNA damage, telomere length, oxidative status their urine, liver, kidneys. Despite employing this experimental our results did not provide conclusive evidence across evaluated organs. However, observed sex-dependent differences response treatment. high potency compounds, further research is warranted explore incorporation into daily routines as strategy mitigate ageing-related effects.

Language: Английский

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