SARS-CoV-2 infection and cognitive impairment in older adults at a family medicine unit in Mexico DOI Open Access

José F. González Maya,

Francisco Vargas Hernández,

Eugenia Adela Monroy Ramírez

et al.

International Journal of Family & Community Medicine, Journal Year: 2025, Volume and Issue: 9(2), P. 27 - 34

Published: Jan. 1, 2025

Introduction: It has been documented that SARS-CoV-2 infection can cause alterations in brain function, although the specific neurocognitive sequelae are not yet fully understood. Mechanisms involved include inflammation mediated by proinflammatory cytokines such as IL-4 and IL-6, generation of autoantibodies an abnormal TH2-mediated immune response. In addition, other mechanisms reactivation latent viruses, direct viral invasion into central nervous system, disruption blood-brain barrier, hypercoagulation presence microhaemorrhages have proposed, all which may contribute to pathophysiology neurological damage. General objective: To determine association between cognitive impairment mild post-COVID 19 older adults Family Medicine Unit No. 64 “Instituto Mexicano del Seguro Social” (Mexican Institute Social Security (IMSS, for its acronym Spanish)). Material methods: A cross-sectional analytical study aged 60-65 years old with confirmed rapid antigen test was carried out. Sixty-four subjects per group were included selected non-probabilistic convenience sampling. The analysed Pearson’s chi-squared test, multiple binary logistic regression applied control confounding factors. Results: Out a total 128 subjects, 93.8% participants cognitively impaired. Of these, 59.6% had comorbidities, systemic arterial hypertension being most prevalent. multivariate analysis, associated OR 6.86 [95% CI p<0.05]. contrast, T2D [OR 1.36 (95% CI) p .53], SAH (OR 1.25, 95% CI, .651) obesity 1.14, .810). Conclusion: Cognitive positivity, highlighting importance assessment at primary care level Mexico.

Language: Английский

Neuropsychiatric aspects of long COVID: A comprehensive review DOI Creative Commons
Takafumi Kubota, Naoto Kuroda, Daichi Sone

et al.

Psychiatry and Clinical Neurosciences, Journal Year: 2022, Volume and Issue: 77(2), P. 84 - 93

Published: Nov. 17, 2022

Although some patients have persistent symptoms or develop new following coronavirus disease 2019 (COVID-19) infection, neuropsychiatric aspects of long COVID are not well known. This review summarizes and provides an update on the dimensions COVID. Its manifestations commonly include fatigue, cognitive impairment, sleep disorders, depression, anxiety, post-traumatic stress disorder. There no specific tests for COVID, but characteristic findings such as hypometabolism positron emission tomography been reported. The possible mechanisms inflammation, ischemic effects, direct viral invasion, social environmental changes. Some patient characteristics severity complications acute COVID-19 infection may be associated with increased risk symptoms. Long resolve spontaneously persist, depending type established treatments lacking, various psychological pharmacological attempted. Vaccination against plays a key role in prevention disease. With differences among SARS-CoV-2 variants, including omicron variant, likely to change future. Further studies clarifying effective warranted.

Language: Английский

Citations

88
COVID-19 severity is related to poor executive function in people with post-COVID conditions DOI Creative Commons
Mar Ariza,

Neus Cano,

Bárbara Segura

et al.

Journal of Neurology, Journal Year: 2023, Volume and Issue: 270(5), P. 2392 - 2408

Published: March 20, 2023

Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity long-term damage, while others did not observe such associations. This discrepancy can be attributed to methodological and sample variations. We aimed clarify the relationship between outcomes determine whether initial symptomatology predict Cognitive evaluations were performed on 109 healthy controls 319 post-COVID individuals categorized into three groups according WHO clinical progression scale: severe-critical (n = 77), moderate-hospitalized 73), outpatients 169). Principal component analysis was used identify factors associated symptoms in acute-phase domains. Analyses of variance regression linear models study intergroup differences The group significantly worse than control general cognition (Montreal Assessment), executive function (Digit symbol, Trail Making Test B, phonetic fluency), social (Reading Mind Eyes test). Five components emerged from principal analysis: "Neurologic/Pain/Dermatologic" "Digestive/Headache", "Respiratory/Fever/Fatigue/Psychiatric" "Smell/ Taste" predictors Montreal Assessment scores; predicted attention working memory; verbal memory, "Respiratory/Fever/Fatigue/Psychiatric," "Neurologic/Pain/Dermatologic," "Digestive/Headache" function. severe exhibited persistent deficits Several sequelae, indicating role systemic inflammation neuroinflammation COVID-19." Study Registration: www.ClinicalTrials.gov , identifier NCT05307549 NCT05307575.

Language: Английский

Citations

41
Associations of subjective and objective cognitive functioning after COVID-19: A six-month follow-up of ICU, ward, and home-isolated patients DOI Creative Commons
Riikka Pihlaja, Lina-Lotta Kauhanen, Henriikka Ollila

et al.

Brain Behavior & Immunity - Health, Journal Year: 2023, Volume and Issue: 27, P. 100587 - 100587

Published: Jan. 5, 2023

Subjective and objective cognitive dysfunction are reported after COVID-19 but with limited data on their congruence associations the severity of acute disease. The aim this cohort study is to describe prevalence subjective at three six months symptoms psychological disease-related factors.We assessed a 184 patients COVID-19: 82 admitted Intensive Care Unit (ICU), 53 regular hospital wards, 49 isolated home. A non-COVID control group individuals was included. Demographic clinical were collected. symptoms, impairment, depressive post-traumatic stress disorder (PTSD) assessed.At months, impairment by 32.3% ICU-treated, 37.3% ward-treated, 33.3% home-isolated observed in 36.1% 34.7% 8.9% patients. associated PTSD female sex, not assessment or metrics.One-third patients, regardless disease severity, high levels which results from screening demographic factors. Our stresses importance thorough reporting long-term for underlying mental health related factors such as depression.

Language: Английский

Citations

38
The Effects of SARS-CoV-2 Infection on the Cognitive Functioning of Patients with Pre-Existing Dementia DOI Creative Commons
Souvik Dubey, Shambaditya Das, Ritwik Ghosh

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2023, Volume and Issue: 7(1), P. 119 - 128

Published: Feb. 2, 2023

Background: Cognitive postscripts of COVID-19, codenamed as ‘cognitive COVID’ or ‘brain fog,’ characterized by multidomain cognitive impairments, are now being reckoned the most devastating sequelae COVID-19. However, impact on already demented brain has not been studied. Objective: We aimed to assess functioning and neuroimaging following SARS-CoV-2 infection in patients with pre-existing dementia. Methods: Fourteen COVID-19 survivors dementia (four Alzheimer’s disease, five vascular dementia, three Parkinson’s disease two behavioral variant frontotemporal dementia) were recruited. All these had detailed evaluations within months before suffering from one year later. Results: Of 14 patients, ten required hospitalization. developed increased white matter hyperintensities that mimicked multiple sclerosis small vessel disease. There was a significant increase fatigue ( p = 0.001) depression 0.016) scores The mean Frontal Assessment Battery (p < Addenbrooke’s Examination also significantly worsened. Conclusion: rapid progression addition further impairments/deterioration abilities, new appearance lesion burden suggest previously compromised brains have little defense withstand insult (i.e., ‘second hit’ like infection/dysregulated immune response, inflammation). ‘Brain fog’ is an ambiguous terminology without specific attribution spectrum post-COVID-19 sequelae. propose codename, i.e. ‘FADE-IN MEMORY’ Fatigue, decreased Fluency, Attention deficit, Depression, Executive dysfunction, slowed INformation processing speed, subcortical MEMORY impairment).

Language: Английский

Citations

38
Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors DOI
Min Qiao, Junjun Ni,

Hong Qing

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1
A Computerized Cognitive Test Battery for Detection of Dementia and Mild Cognitive Impairment: Instrument Validation Study DOI Creative Commons
Siao Ye,

Kevin Sun,

Duong P. Huynh

et al.

JMIR Aging, Journal Year: 2022, Volume and Issue: 5(2), P. e36825 - e36825

Published: March 14, 2022

Early detection of dementia is critical for intervention and care planning but remains difficult. Computerized cognitive testing provides an accessible promising solution to address these current challenges.

Language: Английский

Citations

35
Cognitive Impairment after Post-Acute COVID-19 Infection: A Systematic Review of the Literature DOI Open Access
Andrea Perrottelli, Noemi Sansone, Giulia Maria Giordano

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(12), P. 2070 - 2070

Published: Dec. 15, 2022

The present study aims to provide a critical overview of the literature on relationships between post-acute COVID-19 infection and cognitive impairment, highlighting limitations confounding factors. A systematic search articles published from 1 January 2020 July 2022 was performed in PubMed/Medline. We followed Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Only studies using validated instruments assessment impairment were included. Out 5515 screened records, 72 met inclusion criteria. available evidence revealed presence executive functions, speed processing, attention memory subjects recovered COVID-19. However, several reviewed should be highlighted: most small samples, not stratified by severity disease age, used as cross-sectional or short-term longitudinal design provided limited different domains. Few investigated neurobiological correlates deficits individuals Further with an adequate methodological are needed in-depth characterization

Language: Английский

Citations

35
Symptom Clusters Seen in Adult COVID-19 Recovery Clinic Care Seekers DOI Open Access
Valerie Danesh, Alejandro C. Arroliga, James A. Bourgeois

et al.

Journal of General Internal Medicine, Journal Year: 2022, Volume and Issue: 38(2), P. 442 - 449

Published: Nov. 14, 2022

Language: Английский

Citations

32
Enhanced External Counterpulsation Improves Cognitive Function of Persons with Long COVID DOI
Mohanakrishnan Sathyamoorthy,

Rajkumar J. Sevak,

J. Cabrera

et al.

American Journal of Physical Medicine & Rehabilitation, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 3, 2024

ABSTRACT Objective To determine the effects of Enhanced External Counterpulsation (EECP) in patients with long COVID and objectively assessed cognitive impairment. Design A retrospective evaluation referred for EECP, sequela, having completed an objective digital assessment before after therapy. Patients had either impairment (CI) or no (NCI) at baseline. We changes composite score using multi-factor ANOVA. Multiple linear logistic regression analyses were conducted to evaluate several independent variables. Results 80 (38 CI vs 42 NCI) included analyses. All baseline characteristics well matched. There was significant improvement post-EECP those notable documented safety concerns. Conclusion This is first study showing that EECP led functioning defined Although a lack negative control group limitation this study, appears be highly safe effective potential widespread application.

Language: Английский

Citations

6
Psychometric properties of the COVID-19 Yorkshire Rehabilitation Scale: Post-Covid-19 syndrome in Iranian elderly population DOI Creative Commons

Negar Tamadoni,

Afsaneh Bakhtiari, Hossein‐Ali Nikbakht

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 11, 2024

Abstract Background This study aimed to assess the construct validity and reliability of Iranian version COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) among elderly population. Method A cohort 230 individuals who tested positive for Covid-19 via PCR were administered a health demographic information questionnaire along with C19-YRS. Both exploratory confirmatory factor analyses conducted, Cronbach’s alpha was calculated. Results Findings from C19-YRS revealed alterations compared original version, resulting in an adapted three factors achieved by redistributing questions. These accounted 57.46% total variance. Despite relatively lower loading 6th question, it retained due its significance elderly. The subscales ranged 0.730 0.890, indicating acceptable reliability. Conclusion validation results indicated well-adjusted structure internal consistency, affirming utility this tool Consequently, Iran can serve as valuable resource healthcare settings, aiding assessment chronic complications arising It be utilized initial screening or triage test evaluate effectiveness interventions.

Language: Английский

Citations

6