How ephapticity can explain brain complexity? DOI Creative Commons
Gabriel Moreno Cunha,

Matheus Phellipe Brasil de Sousa,

Gilberto Corso

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 7, 2023

Abstract The origin of brain complexity remains an open question within the field neuroscience. Although acknowledged significance synaptic stimuli, their efficacy frequently proves inadequate in explaining both profound intricacies and refined levels cognitive integration. Recent investigations neuroscience have cast doubt on mechanisms by which generates highly complex, intricate dynamics, emergent patterns, sophisticated oscillation signals. In this interesting context, our study, line with contemporary research, postulates hypothesis that ephaptic communication may emerge as prime candidate to elucidate neuronal complexity. present research carried out a comparative analysis between two types networks using Quadratic Integrate-and-Fire-Ephaptic model: (I) small-world network (II) mixed composite comprising augmented network. We employ Multiscale Scale Entropy approach examine responses networks, estimated summing across all temporal scales. outcomes clarify coupling amplifies under specific conditions, taking into account variables such timescale intensity. These results provide new insights balance nervous system communications underscore fundamental role ephapticity orchestrating complex functions. Consequently, significantly contributes advancing deeper understanding intricate, dynamics inherent activities.

Language: Английский

Thermal effects and ephaptic entrainment in Hodgkin–Huxley model DOI Creative Commons

Matheus Phellipe Brasil de Sousa,

Gabriel Moreno Cunha, Gilberto Corso

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 29, 2024

The brain is understood as an intricate biological system composed of numerous elements. It susceptible to various physical and chemical influences, including temperature. literature extensively explores the conditions that influence synapses in context cellular communication. However, understanding how brain's global can modulate ephaptic communication remains limited due poorly nature ephapticity. This study proposes adaptation Hodgkin Huxley (HH) model investigate effects entrainment response thermal changes (HH-E). analysis focuses on two distinct neuronal regimes: subthreshold suprathreshold. In regime, circular statistics are used demonstrate dependence phase differences with suprathreshold Inter-Spike Interval employed estimate preferences spiking pattern. Temperature influences model's interactions modify its for frequency, direction this change depending specific temperature range under consideration. Furthermore, enhance anti-phase relationship between spikes external signal. also influenced by temperature, especially at low frequencies. reveals susceptibility variations both regimes discusses importance contexts where may plays a significant role neural physiology, such inflammatory processes, fever, epileptic seizures.

Language: Английский

Citations

3
Oscillatory Transcranial Electrical Stimulation and the Amplitude‐Modulated Frequency Dictate the Quantitative Features of Phosphenes DOI Creative Commons

Che‐Yi Hsu,

Tzu‐Ling Liu, Chi‐Hung Juan

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(1)

Published: Jan. 1, 2025

ABSTRACT Previous research demonstrated that transcranial alternating current stimulation (tACS) can induce phosphene perception. However, tACS involves rhythmic changes in the electric field and polarity (excitatory vs. inhibitory phases), leaving precise mechanism behind perception unclear. To disentangle effects of from those polarity, this study employs oscillatory direct (otDCS), which oscillation remains confined to either a positive or negative thereby eliminating influence switching. We applied scalp electrical stimulations using both polarity‐switching non‐polarity‐switching (otDCS) methods, with anodal cathodal polarities, targeting occipital lobe. All were performed sinusoidal amplitude modulation (AM) waveforms at threshold suprathreshold intensities. Our results show faster response times compared otDCS, but not while otDCS elicits greater brightness than tACS. Additionally, AM frequency induced higher frequency, slower condition across all positive, negative, stimulations. intensity could speed ratings, unlike conditions. findings reveal phosphenes, significant differences between polarities types, indicating mechanisms are critical induction. This provides evidence linking occurrence activity highlights robustness impact coding visual

Language: Английский

Citations

0
The transition from biology to phenomenology DOI Creative Commons

Erling T. Mellerup

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111665 - 111665

Published: May 1, 2025

Language: Английский

Citations

0
Laying the foundations for a theory of consciousness: the significance of critical brain dynamics for the formation of conscious states DOI Creative Commons
Joachim Keppler

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 26, 2024

Empirical evidence indicates that conscious states, distinguished by the presence of phenomenal qualities, are closely linked to synchronized neural activity patterns whose dynamical characteristics can be attributed self-organized criticality and phase transitions. These findings imply insight into mechanism which brain controls transitions will provide a deeper understanding fundamental manages transcend threshold consciousness. This article aims show initiation formation is due coupling zero-point field (ZPF), plays central role in quantum electrodynamics (QED). The ZPF stands for ubiquitous vacuum fluctuations electromagnetic field, represented spectrum normal modes. With reference QED-based model calculations, details revealed, suggesting critical dynamics governed resonant interaction with most abundant neurotransmitter glutamate. pyramidal neurons cortical microcolumns turn out ideally suited control this interaction. A direct consequence glutamate-ZPF amplification specific modes, leads us conclude key consciousness distinctive feature neurophysiological processes associated experience consists modulating ZPF. Postulating an inherently sentient assuming qualities modes ZPF, significance states becomes apparent inextricably excitation qualities. theory consciousness, according arise through given acronym TRAZE. An experimental setup specified used test corollary theory, namely, prediction normally occurring perceptions absent under conditions disrupted.

Language: Английский

Citations

1
Dynamical Asymmetries, the Bayes’ Theorem, Entanglement, and Intentionality in the Brain Functional Activity DOI Open Access
David Bernal‐Casas, Giuseppe Vitiello

Symmetry, Journal Year: 2023, Volume and Issue: 15(12), P. 2184 - 2184

Published: Dec. 11, 2023

We discuss the asymmetries of dynamical origin that are relevant to functional brain activity. The is permanently open its environment, and dissipative dynamics characterized indeed by under time translation transformations time-reversal transformations, which manifest themselves in irreversible “arrow time”. Another asymmetry arises from breakdown rotational symmetry molecular electric dipoles, triggered incoming stimuli, manifests long-range dipole-dipole correlations favoring neuronal correlations. In model, neurons, glial cells, other biological components classical structures. dipole vibrational fields quantum variables. review field theory model proposed Ricciardi Umezawa subsequent extension dynamics. then show Bayes’ theorem probability intrinsic structure states strict relation with entanglement phenomena free energy minimization. estimates action a higher Bayes be taken produce aimed effect. rule provides formal basis intentionality activity, we also mind consciousness.

Language: Английский

Citations

3
The necessary and sufficient mechanism of consciousness in a layered mind DOI Creative Commons
Zenan Ruan

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 28, 2023

OPINION article Front. Psychol., 28 September 2023Sec. Consciousness Research Volume 14 - 2023 | https://doi.org/10.3389/fpsyg.2023.1280959

Language: Английский

Citations

2
Thermal effects and ephaptic entrainment in Hodgkin-Huxley model DOI Creative Commons

Matheus Phellipe Brasil de Sousa,

Gabriel Moreno Cunha, Gilberto Corso

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Abstract The brain is understood as an intricate biological system composed of multiple elements. It susceptible to diverse physical and chemical influences, including temperature. literature widely explores the conditions that affect synapses in context cellular communications. However, understanding how global can modulate ephaptic communication remains limited, because still poorly nature ephapticity. This study proposes adaptation Hodgkin Huxley model, HH-E, investigate effects entrainment response thermal changes. analysis focus on two distinct neuronal regimes: subthreshold suprathreshold. In regime, circular statistic used show phase differences dependence suprathreshold Population Vector Inter-Spike Interval are estimate preferences changes spiking pattern. Temperature affects positively HH-E model frequency. At high temperatures collapses no more observed. Moreover, temperature difference improves anti-phase between spikes external signal. influenced by temperature, specially at low frequencies. Finally, this reveals susceptibility variations both regimes discusses importance pathological contexts which play important role neural physiology, such inflammatory processes, fever epileptic seizures.

Language: Английский

Citations

0
Can ephapticity contribute to the brain complexity? DOI Creative Commons
Gabriel Moreno Cunha, Gilberto Corso,

Matheus Phellipe Brasil de Sousa

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract The inquiry into the origin of brain complexity remains a pivotal question in neuroscience. While synaptic stimuli are acknowledged as significant, their efficacy often falls short elucidating extensive interconnections and nuanced levels cognitive integration. Recent advances neuroscience have brought mechanisms underlying generation highly intricate dynamics, emergent patterns, sophisticated oscillatory signals question. Within this context, our study, alignment with current research, posits hypothesis that ephaptic communication may emerge primary candidate for unraveling optimal complexity. In investigation, we conducted comparative analysis between two types networks utilizing Quadratic Integrate-and-Fire Ephaptic model (QIF-E): (I) small-world network (ephaptic-off) (II) mixed composite comprising addition an (ephaptic-on). Utilizing Multiscale Entropy methodology, in-depth responses generated by both configurations, assessed integrating across all temporal scales. Our findings demonstrate coupling enhances under specific topological conditions, considering variables such time, spatial scales, intensity. These results offer fresh insights dynamics within nervous system underscore fundamental role ephapticity regulating complex functions.

Language: Английский

Citations

0
Biological life has a non-material side: Expanding our scientific worldview may be critical for securing the Earth-life system DOI Open Access
Craig Liddicoat

Published: Aug. 25, 2024

The future of humanity and the environment are intertwined. Our collective growth shapes disrupts environmental systems at planetary-scale. We pursue increasingly technological futures, while warning need to repair natural biosphere that sustain us. Facing globally interconnected challenges, scientific approaches guide our decision-making have never been more important for informing future. Physicalist (physical-only), reductionistic worldviews, which strive eliminate subjectivity, provide conceptual framing mainstream views purport completely frame describe biological life. However, we observe ample case studies from biology, ecology, human health, animal behavior, other life sciences where course events shaped by intrinsic cognitive subjective assessments benefits drawbacks. It is argued such perceptions, adaptive goal-directed behaviors, represent an overlooked non-material facet or dimension, linked bioelectric read/write/compute capacity, critical organism-, ecosystem-, biosphere-scales.

Language: Английский

Citations

0
Two Levels of Integrated Information Theory: From Autonomous Systems to Conscious Life DOI Creative Commons
Zenan Ruan, Hengwei Li

Entropy, Journal Year: 2024, Volume and Issue: 26(9), P. 761 - 761

Published: Sept. 5, 2024

Integrated Information Theory (IIT) is one of the most prominent candidates for a theory consciousness, although it has received much criticism trying to live up expectations. Based on relevance three issues generalized from developments IITs, we have summarized main ideas IIT into two levels. At second level, claims be strictly anchoring but first level which based more about autonomous systems or that reached some other critical complexity. In this paper, argue clear gap between levels explanation led these criticisms and its panpsychist tendency plays crucial role in this. We suggest problems are far being "pseudoscience", by adding necessary elements, when combined with can genuinely move toward an appropriate consciousness provide sufficient interpretations.

Language: Английский

Citations

0