Diagnostic accuracy of a modularized, virtual-reality-based automated pupillometer for detection of relative afferent pupillary defect in unilateral optic neuropathies DOI Creative Commons
Rahul Negi,

Manasa Kalivemula,

Karan Bisht

et al.

Frontiers in Ophthalmology, Journal Year: 2024, Volume and Issue: 4

Published: Sept. 3, 2024

Purpose To describe the construction and diagnostic accuracy of a modularized, virtual reality (VR)-based, pupillometer for detecting relative afferent pupillary defect (RAPD) in unilateral optic neuropathies, vis-à-vis, clinical grading by experienced neuro-ophthalmologists. Methods Protocols swinging flashlight test light response analysis used previous stand-alone was integrated into hardware Pico Neo 2 Eye ® VR headset with built-in eye tracker. Each 77 cases (mean ± 1SD age: 39.1 14.9yrs) age-similar controls were stimulated independently thrice 1sec at 125lux intensity, followed 3sec darkness. RAPD quantified as ratio direct reflex stronger to weaker eye. Device performance evaluated using standard ROC analysis. Results The median (25th – 75th quartiles) pupil constriction affected 38% (17 23%) smaller than their fellow (p<0.001), compared an interocular difference +/-6% (3 15%) controls. sensitivity detection 78.5% entire dataset it improved 85.1% when physiological asymmetries bilateral miosis accounted for. Specificity area under curve remained between 81 96.3% across all analyses. Conclusions may be successfully neuro-ophthalmic pathology VR-technology-based modularized pupillometer. Such objective estimation provides immunity against biases variability grading, overall enhancing its value decision making.

Language: Английский

Pupil size as a biomarker of cognitive (dys)functions: Toward a physiologically informed screening of mental states DOI
Serena Castellotti, Elisa Castaldi, Elvio Blini

et al.

Acta Psychologica, Journal Year: 2025, Volume and Issue: 253, P. 104720 - 104720

Published: Jan. 11, 2025

Language: Английский

Citations

0
Chromatic Pupillary Light Reflex in Two Dogs With Amaurosis Secondary to Optic Pathway Disorders DOI Open Access
Koen M. Santifort, Marta Płonek,

Christiane Görig

et al.

Veterinary Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Chromatic (colorimetric) pupillary light reflexes (cPLR) are reportedly useful in canine neuro-ophthalmology to differentiate sudden acquired retinal degeneration syndrome (SARDS) from optic pathway disease (neurological disorders) causing acute blindness. We report two cases with cPLR test results reported be consistent primary that were subsequently diagnosed (CNS) disease. A 7-year-old Dachshund and a Weimaraner presented for Both dogs failed obstacle tests, showed absent menace responses, bilateral mydriasis, PLRs white both eyes. The cPLRs tested using BPI-50 Precision Illuminator (Retinographics Inc., USA). exhibited no PLR red (660 nm), brisk though incomplete constriction blue (465 nm) at 200 kcd/m2. Electroretinograms (ERG) of eyes normal dogs. Magnetic resonance imaging (MRI) the brain revealed left-sided cystic extra-axial mass (suspected meningioma) rostral cranial fossa lesion affecting bones skull base nerves (confirmed lymphoma). These first acute, amaurosis due present light-cPLR.

Language: Английский

Citations

0
Diagnostic performance of light reflex pupillometry in Alzheimer's disease DOI Creative Commons
Mathias Holsey Gramkow, Frederikke Kragh Clemmensen,

Nikolai Sulkjær Sjælland

et al.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Journal Year: 2024, Volume and Issue: 16(3)

Published: July 1, 2024

Abstract Easily applied diagnostic tools such as digital biomarkers for Alzheimer's disease (AD) are urgently needed due to the recent approval of disease‐modifying therapies. We aimed determine performance hand‐held, quantitative light reflex pupillometry (qLRP) in patients with AD a proof‐of‐concept, cross‐sectional study. Participants underwent qLRP at university memory clinic from August 2022 October 2023. fitted multivariable logistic regression models qLRP, sex, and age predictors evaluated area under receiver operating characteristics curve (AUROC). In total, 107 AD, 44 mixed vascular cognitive dysfunction (VCD), 53 dementia Lewy bodies (DLB), 50 healthy controls (HCs) were included. Our showed similar discriminatory ability (AUROC range 0.74‐0.81) when distinguishing HCs other dementias. The seems promising bedside biomarker aid diagnosing AD. Highlights demonstrated disease. robust sensitivity analyses. may assist evaluation

Language: Английский

Citations

1
Diagnostic accuracy of a modularized, virtual-reality-based automated pupillometer for detection of relative afferent pupillary defect in unilateral optic neuropathies DOI Creative Commons
Rahul Negi,

Manasa Kalivemula,

Karan Bisht

et al.

Frontiers in Ophthalmology, Journal Year: 2024, Volume and Issue: 4

Published: Sept. 3, 2024

Purpose To describe the construction and diagnostic accuracy of a modularized, virtual reality (VR)-based, pupillometer for detecting relative afferent pupillary defect (RAPD) in unilateral optic neuropathies, vis-à-vis, clinical grading by experienced neuro-ophthalmologists. Methods Protocols swinging flashlight test light response analysis used previous stand-alone was integrated into hardware Pico Neo 2 Eye ® VR headset with built-in eye tracker. Each 77 cases (mean ± 1SD age: 39.1 14.9yrs) age-similar controls were stimulated independently thrice 1sec at 125lux intensity, followed 3sec darkness. RAPD quantified as ratio direct reflex stronger to weaker eye. Device performance evaluated using standard ROC analysis. Results The median (25th – 75th quartiles) pupil constriction affected 38% (17 23%) smaller than their fellow (p<0.001), compared an interocular difference +/-6% (3 15%) controls. sensitivity detection 78.5% entire dataset it improved 85.1% when physiological asymmetries bilateral miosis accounted for. Specificity area under curve remained between 81 96.3% across all analyses. Conclusions may be successfully neuro-ophthalmic pathology VR-technology-based modularized pupillometer. Such objective estimation provides immunity against biases variability grading, overall enhancing its value decision making.

Language: Английский

Citations

1