Functional segregation of cortical hand and speech areas by frequency detuning of an intrinsic motor rhythm DOI Creative Commons
Ioanna Anastasopoulou, Douglas Cheyne, Blake W. Johnson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

ABSTRACT Many decades after Penfield’s (1937) classic depiction of the motor homunculus, it remains unclear how spatially contiguous and interconnected representations within human sensorimotor cortex might separate their activities to achieve directed precise control distinct body regions evident in as different typing speaking. One long-standing but relatively neglected explanation draws from models simple physical systems (like swinging pendulums) posit that small differences oscillatory properties neuronal populations (termed “frequency detuning”) can result highly effective segregation outputs. We tested this hypothesis by comparing peak frequencies beta-band (13-30 Hz) rhythms measured a magnetoencephalographic neuroimaging study finger speech movements group healthy adults typically developing children. Our results confirm frequency task difference about 1.5 Hz beta both left right hemispheres adults. A comparable was obtained children for not hemisphere. These provide novel support role detuning functional organisation brain suggest mechanism should play more prominent current bodily development cortex. NEW & NOTEWORTHY This work is first evidence an intrinsic rhythm primary associated with hand movements, supporting has been largely overlooked organization. further brain, indicating early-developing later refinements hemispheric control.

Language: Английский

Evaluating evidence for the cortical localization for language: Systematic reviews in the 1860s and 1870s DOI Creative Commons
Marjorie Perlman Lorch

Journal of the History of the Neurosciences, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: May 1, 2025

The specialization of cortical function for language was proposed by Paul Broca (1824-1880) in 1861 and further elaborated to include the principle hemispheric lateralization 1865. other French colleagues argued against these hypotheses, employing clinical pathological observations individuals with acquired disorders as evidence. These ideas became a topic widespread interest after debates at Paris Academy Medicine 1865 were reported internationally. During this period until end decade, hundreds publications appeared on localization laterality findings aphasic case series. Several large-scale systematic reviews historic (pre-1861) contemporary (post-1861) published only few years syndrome had been proposed. aimed determine strength quality evidence regarding brain areas language. However, their authors held distinct theoretical assumptions ideological concerns motivated varied research questions. comprehensive efforts using review methodology assess hypotheses about organization are examined expose issues live debate early neuroscience.

Language: Английский

Citations

0
Functional segregation of cortical hand and speech areas by frequency detuning of an intrinsic motor rhythm DOI Creative Commons
Ioanna Anastasopoulou, Douglas Cheyne, Blake W. Johnson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

ABSTRACT Many decades after Penfield’s (1937) classic depiction of the motor homunculus, it remains unclear how spatially contiguous and interconnected representations within human sensorimotor cortex might separate their activities to achieve directed precise control distinct body regions evident in as different typing speaking. One long-standing but relatively neglected explanation draws from models simple physical systems (like swinging pendulums) posit that small differences oscillatory properties neuronal populations (termed “frequency detuning”) can result highly effective segregation outputs. We tested this hypothesis by comparing peak frequencies beta-band (13-30 Hz) rhythms measured a magnetoencephalographic neuroimaging study finger speech movements group healthy adults typically developing children. Our results confirm frequency task difference about 1.5 Hz beta both left right hemispheres adults. A comparable was obtained children for not hemisphere. These provide novel support role detuning functional organisation brain suggest mechanism should play more prominent current bodily development cortex. NEW & NOTEWORTHY This work is first evidence an intrinsic rhythm primary associated with hand movements, supporting has been largely overlooked organization. further brain, indicating early-developing later refinements hemispheric control.

Language: Английский

Citations

0