BMC Public Health,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: Nov. 6, 2023
Abstract
Background
Depression
is
increasingly
recognized
as
a
worldwide
serious,
public
health
concern.
A
better
understanding
of
depression
important
for
advancing
its
management
and
learning
the
difference
between
major
depressive
disorder
(MDD)
dysthymia.
Our
aim
to
conduct
concurrent
analysis
trends
both
MDD
dysthymia
in
China.
Methods
The
data
on
from
1990
2019
were
collected
Global
Burden
Disease
Study
(GBD
2019).
To
determine
average
annual
percent
changes
(AAPC)
relative
risks
(RRs),
joinpoint
regression
age-period-cohort
models
employed,
respectively.
Results
incidence
number
continuously
increased
China
2019,
however,
age-standardized
rates
(ASR)
had
decreasing
trend
men
women.
results
showed
that
declining
was
presented
young
people
(<
50
years)
but
an
elderly
(≥
women,
during
1990–2019.
Age
most
influential
factor
RRs
overall
increasing
with
age.
Period
RR
U-shaped
pattern,
while
Cohort
inverted
pattern.
On
other
hand,
period
cohort
effects
no
statistical
significance,
only
age
effect
Conclusions
disparities
observed
1990–2019
indicated
significance
distinguishing
these
two
disorders.
age,
all
greater
impact
than
dysthymia,
different
patterns
two.
alleviate
burden
disorders
China,
proactive
measures
need
be
implemented,
particular
attention
population.
The Lancet Public Health,
Journal Year:
2024,
Volume and Issue:
9(5), P. e282 - e294
Published: May 1, 2024
BackgroundSex
and
gender
shape
health.
There
is
a
growing
body
of
evidence
focused
on
comprehensively
systematically
examining
the
magnitude,
persistence,
nature
differences
in
health
between
females
males.
Here,
we
aimed
to
quantify
leading
causes
disease
burden
males
across
ages
geographies.MethodsWe
used
Global
Burden
Disease
Study
2021
compare
disability-adjusted
life-year
(DALY)
rates
for
20
individuals
older
than
10
years
at
global
level
seven
world
regions,
1990
2021.
We
present
absolute
relative
cause-specific
DALY
males.FindingsGlobally,
had
higher
morbidity-driven
conditions
with
largest
DALYs
low
back
pain
(with
478·5
[95%
uncertainty
interval
346·3–632·8]
more
per
100
000
among
males),
depressive
disorders
(348·3
[241·3–471·0]),
headache
(332·9
[48·3–731·9]),
whereas
mortality-driven
COVID-19
1767·8
[1581·1–1943·5]
females),
road
injuries
(1012·2
[934·1–1092·9]),
ischaemic
heart
(1611·8
[1405·0–1856·3]).
The
sexes
became
larger
over
age
remained
consistent
time
all
except
HIV/AIDS.
difference
HIV/AIDS
was
observed
those
aged
25–49
sub-Saharan
Africa
1724·8
(918·8–2613·7)
males.InterpretationThe
notable
point
an
urgent
need
policies
be
based
sex-specific
age-specific
data.
It
also
important
continue
promoting
gender-sensitive
research,
ultimately,
implement
interventions
that
not
only
reduce
but
achieve
greater
equity.FundingBill
&
Melinda
Gates
Foundation.
International Journal of Environmental Research and Public Health,
Journal Year:
2023,
Volume and Issue:
20(5), P. 4521 - 4521
Published: March 3, 2023
Musculoskeletal
(MSK)
pain
disorders
are
some
of
the
most
prevalent
and
disabling
chronic
conditions
worldwide.
These
have
a
considerable
impact
on
quality
life
individuals,
families,
communities,
healthcare
systems.
Unfortunately,
burden
MSK
does
not
fall
equally
across
sexes.
Females
consistently
demonstrate
more
severe
clinical
presentations
disorders,
this
disparity
increases
in
magnitude
with
age.
The
aim
present
article
is
to
review
recent
studies
that
examined
sex
differences
between
males
females
four
common
disorders:
neck
pain,
low
back
osteoarthritis,
rheumatoid
arthritis.
Current Oncology,
Journal Year:
2022,
Volume and Issue:
29(11), P. 8751 - 8766
Published: Nov. 15, 2022
Research
suggests
that
colorectal
cancer
(CRC)
is
associated
with
mental
health
disorders,
primarily
anxiety
and
depression.
To
synthesize
this
evidence,
we
conducted
a
systematic
review
meta-analysis
of
studies
evaluating
the
onset
depression
among
patients
CRC.
We
searched
EMBASE
Medline
from
inception
to
June
2022.
included
original,
peer-reviewed
that:
used
an
epidemiologic
design;
CRC
comparator
group
individuals
without
cancer;
evaluated
as
outcomes.
random
effects
models
obtain
pooled
measures
associations.
Quality
assessment
was
completed
using
Newcastle-Ottawa
scale.
Of
7326
articles
identified,
8
were
eligible;
which
6
assessed
2
only.
Meta-analyses
showed
non-significant
association
between
(pooled
HR
1.67;
95%
CI
0.88
3.17)
significant
1.78;
1.23
2.57).
Predictors
clinical
characteristics
(e.g.,
comorbidities,
stage,
site),
treatment
radiotherapy,
chemotherapy,
colostomy),
sociodemographic
age,
sex).
The
impacts
in
increased
mortality
decreased
quality
life.
Altogether,
our
quantified
risks
on
depression,
particularly
risk
after
diagnosis.
Findings
provide
support
for
oncologic
care
encompasses
supports
Frontiers in Psychiatry,
Journal Year:
2023,
Volume and Issue:
14
Published: Feb. 14, 2023
From
the
vulnerability
perspective,
we
often
ask
question
"why
someone
suffers
from
depression?"
Despite
outstanding
achievements
along
this
line,
still
face
high
occurrence
or
recurrence
and
unsatisfied
therapeutic
efficacy
of
depression,
suggesting
that
solely
focusing
on
perspective
is
insufficient
to
prevent
cure
depression.
Importantly,
although
experiencing
same
adversity,
most
people
do
not
suffer
depression
but
manifest
certain
resilience,
which
could
be
used
however,
systematic
review
lack.
Here,
propose
concept
"resilience
depression"
emphasize
resilient
diathesis
against
by
asking
exempted
Research
evidence
resilience
has
been
reviewed
systematically:
positive
cognitive
style
(clear
purpose
in
life,
hopefulness,
et
al.),
emotion
(emotional
stability,
adaptive
behavior
(extraversion,
internal
self-control,
strong
social
interaction
(gratitude
love,
neural
foundation
(dopamine
circuit,
al.).
Inspired
these
evidence,
"psychological
vaccination"
achieved
well-known
real-world
natural-stress
vaccination
(mild,
controllable,
stress,
with
help
parents
leaders)
newly
developed
"clinical
(positive
activity
intervention
for
current
preventive
therapy
remitted
both
aim
enhance
psychological
through
events
training.
Potential
circuit
was
further
discussed.
This
calls
directing
attention
offers
a
new
thinking
prevention
Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
96(4), P. 287 - 299
Published: Feb. 3, 2024
BackgroundChronic
childhood
stress
is
a
prominent
risk
factor
for
developing
affective
disorders,
yet
mechanisms
underlying
this
association
remain
unclear.
Maintenance
of
optimal
serotonin
(5-HT)
levels
during
early
postnatal
development
critical
the
maturation
brain
circuits.
Understanding
long-lasting
effects
life
(ELS)
on
serotonin-modulated
connectivity
crucial
to
develop
treatments
arising
from
stress.MethodsUsing
mouse
model
chronic
developmental
stress,
we
determined
consequences
ELS
5-HT
circuits
and
behavior
in
female
male
mice.
Using
FosTRAP
mice,
cross-correlated
regional
c-fos
density
determine
brain-wide
functional
raphe
nucleus.
We
next
performed
vivo
fiber
photometry
establish
ELS-induced
deficits
dynamics
optogenetics
stimulate
release
improve
behavior.ResultsAdult
mice
exposed
showed
heightened
anxiety-like
behavior.
further
enhanced
susceptibility
acute
by
disrupting
nucleus
activity
neuron
population,
conjunction
with
increased
orbitofrontal
cortex
(OFC)
disrupted
medial
OFC
(mOFC).
Optogenetic
stimulation
terminals
mOFC
elicited
an
anxiolytic
effect
sex-dependent
manner.ConclusionThese
findings
suggest
significant
disruption
5-HT-modulated
response
ELS,
implications
vulnerability.
The
raphe-mOFC
circuit
provides
potential
targeted
stimulation-based
disorders
that
arise
adversities.
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Journal Year:
2024,
Volume and Issue:
134, P. 111073 - 111073
Published: June 22, 2024
One
of
the
most
challenging
and
controversial
issues
in
microbiome
research
is
related
to
gut
microbial
metabolism
neuropsychological
disorders.
Psychobiotics
affect
human
behavior
central
nervous
system
processes
via
gut-brain
axis,
involving
neuronal,
immune,
metabolic
pathways.
They
have
therapeutic
potential
treatment
several
neurodegenerative
neurodevelopmental
disorders
such
as
depression,
anxiety,
autism,
attention
deficit
hyperactivity
disorder,
Alzheimer's
disease,
Parkinson's
schizophrenia,
Huntington's
anorexia
nervosa,
multiple
sclerosis.
However,
mechanisms
underlying
interaction
between
psychobiotics
abovementioned
diseases
need
further
exploration.
This
review
focuses
on
relationship
microbiota
its
impact
neurological
disorders,
examining
a
preventive
approach,
summarising
recent
axis
beneficial
effects
psychobiotics,
highlighting
for
investigation
this
area.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(3), P. 837 - 837
Published: Jan. 27, 2025
Background/Objectives:
Ischemic
heart
disease
(IHD)
is
a
major
cause
of
morbidity
and
mortality
worldwide,
it
frequently
associated
with
depression,
which
can
negatively
impact
both
clinical
outcomes
quality
life.
The
relationship
between
IHD
depression
complex,
gender
differences
influencing
the
severity
willingness
to
seek
psychological
support.
This
study
aims
evaluate
prevalence
in
patients
using
Depression
Assessment
Heart
Disease
Questionnaire
(DA-IHDQ)
explore
help-seeking
behavior.
Methods:
cross-sectional
involved
103
diagnosed
(62
males,
41
females),
data
collected
from
two
general
practice
clinics
Arad,
Romania,
November
2023
2024.
Participants
completed
DA-IHDQ,
self-developed
questionnaire
designed
screen
for
patients.
categorizes
into
four
grades:
minimal
no
mild
moderate
severe
depression.
also
assessed
participants’
interest
receiving
Descriptive
inferential
statistical
analyses
were
performed,
psychometric
properties
including
its
reliability
(Cronbach’s
α
=
0.957)
diagnostic
accuracy
(sensitivity
90.0%,
specificity
98.8%),
evaluated.
Results:
Mild
was
most
common
grade
male
female
patients,
while
least
prevalent.
Males
had
higher
overall
frequency
more
cases
whereas
females
proportion
Additionally,
males
demonstrated
significantly
lower
or
psychiatric
help,
showed
greater
mental
health
DA-IHDQ
exhibited
strong
internal
consistency
high
identifying
depressive
symptoms
Conclusions:
findings
highlight
disparities
engagement,
emphasizing
need
targeted
interventions.
could
serve
as
an
effective
screening
tool
care.
Future
research
should
barriers
among
develop
gender-sensitive
strategies
improve
access
services.
Social Science Computer Review,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Social
media
has
become
an
integral
part
of
daily
life,
shaping
behaviors,
self-perception,
and
emotional
well-being.
However,
its
addictive
use
raises
concerns
about
potential
to
aggravate
psychological
challenges,
particularly
in
the
context
societal
expectations
masculinity.
The
current
report
presents
a
study
exploring
pathways
through
which
social
addiction
contributes
masculine
depression,
specifically
examining
roles
physical
appearance
comparison,
self-esteem,
control
among
men.
By
investigating
these
relationships,
it
aims
provide
insights
into
consequences
for
Structured
questionnaires
were
administered
849
Israeli
men
aged
18
older.
Employing
moderated
sequential
mediation
model
with
as
independent
variable,
comparison
self-esteem
mediators,
depression
dependent
this
also
investigates
moderator
associations
between
addiction,
depression.
analysis,
conducted
using
89
PROCESS
v4.2
macro,
reveals
that
conforming
norm
intensifies
men’s
vulnerability
distress
resulting
from
maladaptive
behaviors
such
can
lead
Furthermore,
trigger
via
psychosocial
factors
low
have
yet
be
explored
These
findings
underscore
importance
targeted
interventions
address
pressures
masculinity
repercussions
excessive
They
emphasize
necessity
raising
awareness
issues
both
public
therapists.
Journal of Personalized Medicine,
Journal Year:
2023,
Volume and Issue:
13(2), P. 224 - 224
Published: Jan. 27, 2023
Depression
is
a
common
mood
disorder
characterized
by
persistent
sadness
and
loss
of
interest.
Research
suggests
an
association
between
the
inclusion
omega-3
fatty
acids
in
diet
reduced
risk
for
depression.
The
present
study
evaluated
effectiveness
acid
supplements
alleviating
depressive
symptoms
patients
with
mild
to
moderate
A
total
165
suffering
from
moderated
depression
were
randomized
receive
supplementation,
antidepressant
(single
agent),
or
combination
supplementation.
clinical
features
assessed
using
Hamilton
Rating
Scale
(HDRS)
during
follow-up
period.
statistically
significant
improvement
was
observed
baseline
first,
second
third
follow-ups
within
each
treatment
arm
as
measured
HRDS
scores
(p
=
0.00001).
Further,
HDRS
at
significantly
lower
on
therapy
supplement
antidepressants
(arm-3)
than
alone
(arm-1)
[Q
5.89;
p
0.0001]
taking
(arm
2)
4.36;
0.0068].
elicited
higher
alone.
