Randomized Laboratory Study of Single-Dose Cannabis, Dronabinol, and Placebo in Patients With Schizophrenia and Cannabis Use Disorder

Schizophrenia Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Abstract Background and Hypothesis Up to 43% of people with schizophrenia have a lifetime cannabis use disorder (CUD). Tetrahydrocannabinol (THC) has been shown exacerbate psychosis in dose-dependent manner, but little research assessed its effects on co-occurring CUD (SCZ-CUD). In this double-dummy, placebo-controlled trial (total n = 130), we hypothesized that modest dose THC would worsen cognitive function not psychosis. Study Design Effects single-dose oral (15 mg dronabinol) or smoked 3.5% cigarettes vs placebo SCZ-CUD CUD-only positive negative symptoms (only for SCZ-CUD), cognition, drug experiences several hours after administration. SCZ-only healthy control participants were also assessed. Results Drug liking was higher groups placebo. Neither nor dronabinol predicted symptom subscale scores 2 5 h, respectively, exposure participants. The group, performed worse than verbal learning (B −9.89; 95% CI: −16.06, −3.18; P .004) attention −0.61; −1.00, −0.23; .002). Every 10-point increment serum + THCC ng/ml associated increased (0.40 points; 0.15, 0.65; .001; ranges 7–49) trends observed performance learning, delayed recall, working memory. Conclusions SCZ-CUD, single functioning without exacerbation administration, dose-response effect seen symptoms.

Language: Английский

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Comparative harms assessments for cannabis, alcohol, and tobacco: Risk for psychosis, cognitive impairment, and traffic accident

Drug Science Policy and Law, Journal Year: 2022, Volume and Issue: 8

Published: Jan. 1, 2022

Researchers have associated cannabis use with risk for psychosis, cognitive impairment, and traffic accident. However, this review shows that the association between moderate psychosis is no stronger, often considerably weaker, than corresponding tobacco use. The same holds associations impairment. For of accident, confirms from alcohol substantially stronger use, while appears to be almost as strong It thus accident generally comparable article discusses different interpretations these comparative harms assessments presents two points methodological critique argue risks other criminalized drugs are probably exaggerated. First, any measurement high escapist activities such drug abuse will affected by general dysfunction underlying reason why a person settles frequent escapism. From perspective, disorder both problems life issues are, in themselves, psychopathology, researchers should careful not conflate selection effect belonging population segment opts lifestyles (putative) harmful itself. Second, criminalization shifts composition user direction more dysfunctional users. substance substances, since people who live troubled lives less likely deterred prospect legal problems.

Language: Английский

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Alcohol and marijuana use predicting next-day absenteeism and engagement at school and work: A daily study of young adults

Addictive Behaviors, Journal Year: 2023, Volume and Issue: 142, P. 107670 - 107670

Published: Feb. 21, 2023

Language: Английский

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Pleiotropic loci for cannabis use disorder severity in multi-ancestry high-risk populations

Molecular and Cellular Neuroscience, Journal Year: 2023, Volume and Issue: 125, P. 103852 - 103852

Published: April 14, 2023

Language: Английский

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<i>Cannabis</i>: Drug of abuse and therapeutic agent, two sides of the same coin

Revista de investigaci�n Cl�nica, Journal Year: 2023, Volume and Issue: 75(3)

Published: July 5, 2023

The consumption of Cannabis sativa plant, known as marijuana in the Western world, for different purposes (therapeutic, intoxicating, and spiritual) due to its psychoactive effects, can be traced back ancient times.Cannabis is most used illicit drug worldwide; however, legal status changing rapidly.Cannabis regulation will allow a better understanding effects misused drug, including new challenges, such availability highly potent extracts.Furthermore, scientific research making significant efforts take advantage potential therapeutic uses active compounds.The science derivatives started with identification phytocannabinoids Δ 9 -tetrahydrocannabinol (Δ -THC) cannabidiol (CBD), allowing formal study complex set triggered by deciphering pharmacology.Δ -THC recognized compound responsible intoxicating Cannabis.Its led discovery endocannabinoid system, neuromodulatory system widespread human body.CBD does not induce intoxication that reason, it focus search cannabinoid clinical applications.This review examines current state knowledge about contrasting perspectives on Cannabis, -THC, CBD: their abuse liability use; two sides same coin.

Language: Английский

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