Exploring the relationship between serum LOX-1, Ox-LDL, and generalized anxiety disorder

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 378, P. 74 - 80

Published: Feb. 27, 2025

Language: Английский

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Effects of ambient fine particulate matter on the exacerbation of psychiatric disorders in southern Taiwan: a case-crossover study

International Journal of Environmental Health Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: March 19, 2025

This study investigated the impact of short-term exposures to ambient fine particulate matter 2.5 (PM2.5) on exacerbation psychiatric disorders (PDs) in southern Taiwan between 2014 and 2020. Data emergency room visits (ERVs) for PDs air pollutant levels were obtained from Chang Gung Research Database Environmental Protection Administration, respectively. A time-stratified case-crossover design was adopted estimate risks ERVs PDs. At lag4 days, a 10-μg/m3 increase PM2.5 associated with significant increases both single- multi-pollutant models, odds ratio (OR) 1.18 [95% confidence interval (95% CI): 1.00, 1.38] (PM2.5), 1.20 CI: 1.43) (PM2.5 + SO2), 1.23 1.03, 1.46) O3), 1.25 1.52) SO2 O3). For cumulative lags (lag0-6), only model OR 1.41 1.93). Among males, observed at lag0-6 days; however, no associations females. In conclusion, exposure increased risk exacerbation, exhibiting delayed effects, male patients found be more sensitive.

Language: Английский

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Pathophysiological Links Between Myocardial Infarction and Anxiety Disorder, Major Depressive Disorder, Bipolar Disorder and Schizophrenia

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 336 - 336

Published: March 25, 2025

There is increasing evidence demonstrating that psychiatric conditions elevate the risk of developing accelerated atherosclerosis and early-onset cardiovascular disease (CVD), including myocardial infarction (MI). Several mechanisms contribute to this observation. The dysfunction autonomic nervous system hyperactivity hypothalamic–pituitary–adrenal axis in these patients development MI. Additionally, with underlying disorders often have abnormal levels anti-inflammatory pro-inflammatory cytokines, which can lead early vascular damage subsequent atherosclerosis. Elevated PAI-1 levels, reduced tPA activity, decreased brain-derived neurotrophic factor (BDNF), influenced by coagulation inflammation, may depression its link Oxidative stress, marked increased reactive species impaired antioxidant defenses, associated cellular has been consistently implicated schizophrenia bipolar disorder, potentially contributing infarction. Finally, molecular genetic studies indicated share potential pleiotropic genes. interplay between underscores importance integrated care approaches manage both mental physical health.

Language: Английский

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Measuring Oxidative Stress By the Iridium Reducing Capacity Assay (Ir-RCA)

Advances in Redox Research, Journal Year: 2025, Volume and Issue: unknown, P. 100129 - 100129

Published: March 1, 2025

Language: Английский

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Lifestyle Psychiatry

Lifestyle Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 325 - 348

Published: Jan. 1, 2025

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