Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: Dec. 28, 2022
Abstract
Background
Transcranial
magnetic
stimulation
(TMS)
has
been
introduced
into
the
intervention
of
autism
spectrum
disorders
(ASD)
as
a
possible
new
therapeutic
option
for
modifying
pathological
neuroplasticity.
However,
stimulating
protocols
rTMS
ASD
have
not
approved
unanimously,
which
affects
clinical
popularization
and
application
rTMS.
In
addition,
there
is
little
research
on
improvement
social
processing
autistic
children
by
Methods
We
explored
efficacy
face
with
protocol
left
high-frequency
right
low-frequency
bilateral
dorsolateral
prefrontal
cortex
(DLPFC),
sample
45
participants
aged
2–18.
Results
Our
results
showed
that
both
score
Childhood
Autism
Rating
Scale
(CARS)
fixations
eyes
human
faces
improved
two-session
intervention,
except
eye
preference.
The
mediation
analysis
indicated
item
“Adaptation
to
Change”
CARS
mediated
dominantly
eye-gaze
behavior
Conclusions
study
revealed
mechanism
in
improving
population,
deepened
understanding
function
treating
disorders,
provided
reference
combined
treatment
ASD.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e32251 - e32251
Published: June 1, 2024
Autism
spectrum
disorder
(ASD)
is
a
behaviorally
defined
complex
neurodevelopmental
syndrome
characterized
by
persistent
social
communication
and
interaction
deficit.
Transcranial
magnetic
stimulation
(TMS)
promising
emerging
tool
for
the
intervention
of
ASD
reducing
both
core
associate
symptoms.
Several
reviews
have
been
published
regarding
TMS-based
treatment,
however,
systematic
review
on
study
characteristics,
specific
stimulating
parameters,
localization
techniques,
stimulated
targets,
behavioral
outcomes,
neuroimage
biomarker
changes
lagged
behind
since
2018.
Here,
we
performed
search
literatures
after
2018
in
PubMed,
Web
Science,
Science
Direct.
After
screening,
final
included
17
articles,
composing
seven
randomized
controlled
trial
studies
ten
open-label
studies.
Two
are
double-blind,
while
other
moderate
to
high
risk
bias
attributing
inadequate
subject-
evaluator-blinding
treatment
allocation.
Five
utilize
theta-burst
mode,
others
apply
repetitive
TMS
with
low
frequency
(five
studies),
(six
combined
(one
study).
Most
researchers
prioritize
bilateral
dorsolateral
prefrontal
lobe
as
target,
parietal
lobule,
inferior
posterior
superior
temporal
sulci
also
emerged
new
targets
attention.
One
third
use
neuronavigation
based
anatomical
resonance
imaging
locate
target.
intervention,
discernible
enhancements
across
scales
evident
stereotyped
behavior,
verbal
domains.
A
comprehensive
literature
spanning
last
five
years
demonstrates
potential
ameliorating
clinical
Psychiatry and Clinical Psychopharmacology,
Journal Year:
2024,
Volume and Issue:
34(1), P. 1 - 8
Published: March 21, 2024
Attention-deficit
hyperactivity
disorder
(ADHD)
is
one
of
the
most
common
neurological
developmental
disorders
in
children,
and
sleep
(SDs)
are
a
comorbidity
children
with
ADHD.
There
currently
no
pharmacological
treatment
options
for
SD
ADHD
preschool
age
(4-6
years).
Repetitive
transcranial
magnetic
stimulation
(rTMS)
novel,
non-invasive
neuromodulation
technique.
This
study
explores
effectiveness
rTMS
comorbid
SDs
preschool-aged
Sleep Medicine,
Journal Year:
2024,
Volume and Issue:
118, P. 78 - 80
Published: April 9, 2024
Sleep
difficulties
can
co-occur
with
autistic
traits
and
have
been
frequently
reported
in
children
diagnosed
autism.
Thus,
sleep
may
impact
neural
development,
cognition,
behavioural
functioning
Interventions,
such
as
repetitive
transcranial
magnetic
stimulation
(rTMS),
that
target
aberrant
structures
underpinning
could
beneficial
effects.
The
rTMS
effects
on
the
pathophysiological
pathways
hypothesised
to
underpin
autism
are
well-established
literature;
however,
clinical
evidence
of
its
potential
improve
is
limited.
While
preliminary
data
promising,
further
robust
studies
warranted
encourage
use
practices.
Journal of Autism and Developmental Disorders,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 18, 2024
Sleep
problems
significantly
affect
the
quality
of
life
autism
spectrum
disorder
(ASD)
children.
This
study
aimed
to
evaluate
effects
a
12-week
ball
combination
exercise,
continuous
theta
burst
stimulation
(cTBS)
stimulation,
and
combined
intervention
on
sleep
in
children
with
ASD.
Forty-five
ASD
were
divided
into
three
groups
(ball
exercise(n
=
12),
cTBS
stimulation(n
10),
(n
12)
control
group
11).
The
underwent
intervention,
while
maintained
daily
activities.
assessed
using
Children's
Habits
Questionnaire
(CSHQ)
scale.
results
revealed
that
after
12
weeks
programs
reduced
post-test
scores
(p
0.002)
<
0.001)
lower
than
baseline
CSHQ
exercise
showed
significant
improvement
anxiety,
there
was
no
statistically
difference
effectiveness
interventions
for
sleep-onset
delay.
outperformed
single
score
anxiety
sub-dimensions.
slightly
superior
performance
onset
latency,
however,
difference.
Three
alleviated
issues
children,
method
proving
more
effective.
validates
non-pharmacologic
approaches
problems.
Future
research
should
delve
deeper
mechanisms
these
children's
improvement.
Child Psychiatry & Human Development,
Journal Year:
2022,
Volume and Issue:
55(4), P. 1010 - 1019
Published: Nov. 11, 2022
Abstract
Aims
and
objectives
:
Individual
alpha
frequency
(IAF)
is
a
biomarker
of
neurophysiological
functioning.
The
IAF-guided
repetitive
transcranial
magnetic
stimulation
(α-rTMS)
increasingly
explored
in
diverse
neurological
conditions.
However,
there
limited
data
on
the
efficacy
safety
α-rTMS
children
with
autism
spectrum
disorder
(ASD).
Materials
methods
IAF,
childhood
rating
scale
(CARS),
Pediatric
Quality
Life
Inventory
4.0
(PedsQLTM
4.0),
semi-structured
interview
patients
that
received
19
sessions
(4
weeks)
were
aggregated
analysed
using
paired
student
t-test
descriptive
method.
Results
Data
retrieved
from
28
(26
males,
aged
3-9years
(mean
±
SD
age:
6.1
1.8years)).
post-α-rTMS
shows
significant
improvement
IAF
(9.4
Hz;
p
≤
0.025
)
towards
10
Hz.
CARS
PedsQLTM
surveys
indicate
patients’
ASD
symptoms
quality
life
improved
significantly.
Specifically,
reports
interviews
suggest
sleep
trouble
–
most
comorbidity.
experiences
minor
side
effects
such
as
hyperactivity
resolved
within
two
hours
following
sessions.
Conclusion
This
study
presents
evidence
improving
symptoms,
comorbid
troubles
children.
these
findings
should
be
interpreted
preliminary
pending
presentation
double-blind,
randomised
clinical
trials.
Frontiers in Neurology,
Journal Year:
2022,
Volume and Issue:
13
Published: Oct. 3, 2022
Background
Children
with
autism
spectrum
disorders
(ASDs)
suffer
from
sleep
to
a
considerable
degree;
however,
there
is
no
safe
and
effective
treatment
available
in
clinical
practice.
The
objective
of
the
trial
assess
effectiveness
auricular
plaster
therapy
(APT)
treating
children
ASD.
Method
This
single-center,
patient-assessor
blind,
randomized
controlled
trial.
A
total
44
preschool
ASD
will
be
included
this
study.
Eligible
participants
randomly
assigned
either
group
or
sham
1:1
ratio.
Participants
different
groups
receive
APT
APT,
respectively,
for
30
sessions
over
days.
primary
outcome
includes
Children's
Sleep
Habits
Questionnaire
(CSHQ),
while
secondary
outcomes
include
Autism
Behavior
Checklist
(ABC)
polysomnography
(PSG)
time,
latency,
awakening
duration,
structures.
CSHQ
ABC
assessed
at
baseline,
10,
20,
30,
60,
90,
120
days
after
randomization,
whereas
PSG
baseline
randomization.
follow-up
period
scheduled
Discussion
results
study
may
provide
evidence
efficacy
as
well
offer
new
alternatives
Trial
registration
CHiCTR.org.cn
(ChiCTR2100048257).
Registered
on
July
5,
2021.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: July 20, 2023
Transcranial
magnetic
stimulation
(TMS)
has
been
introduced
into
the
intervention
of
autism
spectrum
disorders
(ASD)
as
a
possible
new
therapeutic
option
for
modifying
pathological
neuroplasticity.
However,
stimulating
protocols
rTMS
ASD
have
not
approved
unanimously,
which
affects
clinical
popularization
and
application
rTMS.
In
addition,
there
is
little
research
on
improvement
social
processing
autistic
children
by
We
explored
efficacy
face
with
protocol
left
high-frequency
right
low-frequency
bilateral
dorsolateral
prefrontal
cortex
(DLPFC),
sample
45
participants
aged
2-18.
Our
results
showed
that
both
score
Childhood
Autism
Rating
Scale
(CARS)
fixations
eyes
human
faces
improved
two-session
intervention,
except
percentage
fixation.
The
mediation
analysis
indicated
item
"Adaptation
to
Change"
CARS
mediated
dominantly
eye-gaze
behavior
study
revealed
mechanism
in
improving
population,
deepened
understanding
function
treating
disorders,
provided
reference
combined
treatment
ASD.
Acta Médica Grupo Ángeles,
Journal Year:
2024,
Volume and Issue:
22(2), P. 145 - 151
Published: Jan. 1, 2024
Introducción:
la
estimulación
magnética
transcraneal
ha
sido
implementada
para
tratar
las
conductas
repetitivas
del
trastorno
espectro
autista
(ASD,
por
sus
siglas
en
inglés);
sin
embargo,
no
existe
un
consenso
los
parámetros
y
resultados
clínicos.Objetivo:
describir
obtenidos
ensayos
donde
se
aplicó
a
pacientes
con
ASD.Material
métodos:
realizó
una
revisión
sistemática
bases
de
datos
PubMed
Google
Académico,
seleccionaron
estudios
2017
2022,
población
diagnosticada
ASD
según
criterios
DSM-IV
DSM-V,
comorbilidad
bajo
tratamiento
farmacológico/conductual.Debido
heterogeneidad
estudios,
únicamente
empleó
estadística
descriptiva.Resultados:
siete
que
cumplieron
selección.Hubo
mejoría
cuatro
cambio
tres.No
obstante,
son
concluyentes.Conclusión:
individuos
mayor
nivel
disfuncionalidad
más
reaccionan
beneficiosamente
ante
(TMS,
inglés)
funciones
ejecutivas
función
adaptativa,
pero
es
necesario
realizar
comprobar
efectos.
Neurocase,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 9
Published: Dec. 4, 2024
Sleep
spindles
(SS)
and
slow
waves
(SW)
serve
as
indicators
of
the
integrity
thalamocortical
connections,
which
are
often
compromised
in
individuals
with
autism
spectrum
disorder
(ASD).
Transcranial
magnetic
stimulation
(TMS)
can
modulate
brain
activity
associated
ASD.
This
study
evaluated
effects
TMS
on
SS
SW
an
11-year-old
male
ASD
who
received
17
sessions
dorsolateral
prefrontal
cortex.
Both
were
detected
before
after
analyzed
using
self-organizing
maps
(SOM).
Using
SOM,
a
subset
was
identified
that
exhibited
structural
changes
TMS.
