Cited by Integrated Transcriptomics and Network Analysis Identified Altered Neural Mechanisms in Frontal Aging Brain-Associated Alzheimer’s Disease

The neural basis of neuropsychiatric symptoms in Alzheimer’s disease DOI

Nicole K. Zhang,

Selena K. Zhang,

Li I. Zhang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 5, 2024

Neuropsychiatric symptoms (NPS) such as depression, anxiety, apathy and aggression affect up to 90% of Alzheimer's disease (AD) patients. These significantly increase caregiver stress institutionalization rates, more importantly they are correlated with faster cognitive decline. However, the neuronal basis NPS in AD remains largely unknown. Here, we review current understanding related pathology studies patients mouse models. Clinical indicate that prevalence severity vary across different stages types. Neuroimaging postmortem have suggested pathological changes anterior cingulate cortex, hippocampus, prefrontal amygdala linked NPS, although precise mechanisms remain unclear. Studies models indicated amyloid-beta tau-related neurodegeneration cortex NPS-like behavioral deficits. A better phenotypes will pave way for developing a management strategy

Language: Английский

Citations

Limbic and cerebellar effects in Alzheimer-Perusini’s disease: A physics-inspired approach DOI

Maria Mannone, Norbert Marwan, Peppino Fazio

et al.

Biomedical Signal Processing and Control, Journal Year: 2024, Volume and Issue: 103, P. 107355 - 107355

Published: Dec. 30, 2024

Language: Английский

Citations

Commentary: Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors DOI

Jihu Zhao,

Peng Sun, Heng Liu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2023, Volume and Issue: 16

Published: Feb. 8, 2023

OPINION article Front. Mol. Neurosci., 08 February 2023Sec. Brain Disease Mechanisms Volume 16 - 2023 | https://doi.org/10.3389/fnmol.2023.1117121

Language: Английский

Citations

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer’s disease DOI

Benjamin B. Tournier, Kelly Ceyzériat, Aurélien M. Badina

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 30, 2023

Abstract Clinical and translational research has identified deficits in the dopaminergic neurotransmission striatum Alzheimer’s disease (AD) this could be related to pathophysiology of psychiatric symptoms appearing even at early stages pathology. We hypothesized that AD pathology hippocampus may influence absence AD-related lesion mesostriatal circuit. thus chemogenetically manipulated activity hippocampal neurons astrocytes wild-type hemizygous TgF344-AD (Tg) rats, an animal model assessed brain-wide functional output manipulation using vivo Single Photon Emission Computed Tomography measure cerebral blood flow D 2/3 receptor binding. also effects chemogenetic manipulations on astrocytic microglial capacity surround phagocytize Aβ both locally striatum. Our results show acute chronic neuronal stimulation induces widespread brain regional activation pattern, notably with inhibition striatal activation. In these were blunted. Chemogenetic increased density its limit pathology, whereas absent perhaps as a consequence altered connectivity between work suggests alter signalling induce alterations activity. Neuronal protective, Aβ-limiting phenotype microglia, which surrounds plaques limits Αβ concentration more efficiently.

Language: Английский

Citations

Integrated Transcriptomics and Network Analysis Identified Altered Neural Mechanisms in Frontal Aging Brain-Associated Alzheimer’s Disease DOI

Suthipong Chujan, Wanida Cholpraipimolrat, Jutamaad Satayavivad

et al.

Biochemical Genetics, Journal Year: 2023, Volume and Issue: 62(4), P. 2382 - 2398

Published: Nov. 7, 2023

Language: Английский

Citations