Is Atopic Dermatitis Only a Skin Disease?

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(1), P. 837 - 837

Published: Jan. 3, 2023

Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs symptoms, growing evidence suggests AD systemic in nature. Certain diseases can possibly co-occur with as result of coincidental exposure similar environmental factors. However, it also suspected they are linked pathogenesis through more complex genetic immunological mechanisms, but these correlations remain less understood. It great need seek explanations for higher frequency number cardiovascular, autoimmune, neurological, psychiatric, metabolic disorders have been observed epidemiologic investigations among patients. Moreover, analysing immunology chronic inflammation its correction, activation, or suppression may prevent development variety comorbidities. As comorbid patients diagnosed potentially go undetected, physicians should be aware them.

Language: Английский

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Causal relationships between atopic dermatitis and psychiatric disorders: a bidirectional two-sample Mendelian randomization study

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 3, 2024

Observational studies have suggested the potential associations between atopic dermatitis (AD) and psychiatric disorders. However, causal relationship them remains uncertain. This study aimed to evaluate bidirectional AD disorders, including autism spectrum disorder (ASD), major depressive (MDD), attention deficit hyperactivity (ADHD), bipolar (BD), anorexia nervosa (AN), Tourette syndrome (TS), schizophrenia, anxiety.

Language: Английский

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The Notch1/Hes1 pathway regulates Neuregulin 1/ErbB4 and participates in microglial activation in rats with VPA-induced autism

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2024, Volume and Issue: 131, P. 110947 - 110947

Published: Jan. 17, 2024

Language: Английский

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Serum Neurofilament Light Chain and Glial Fibrillary Acidic Protein as Potential Diagnostic Biomarkers in Autism Spectrum Disorders: A Preliminary Study

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 3057 - 3057

Published: Feb. 3, 2023

Autism spectrum disorder (ASD) is one of the most common neurodevelopment disorders, characterized by a multifactorial etiology based on interaction genetic and environmental factors. Recent evidence supports neurobiological hypothesis neuroinflammation theory. To date, there are no sufficiently validated diagnostic prognostic biomarkers for ASD. Therefore, we decided to investigate potential role ASD two well known other neurological inflammatory conditions: glial fibrillary acidic protein (GFAP) neurofilament (Nfl). Nfl GFAP serum levels were analyzed using SiMoA technology in group patients healthy control (CTRS), age- gender-matched. Then investigated distribution, frequency, correlation between clinical data among group. The comparison children showed mean value these markers significantly higher (sNfL pt 6.86 pg/mL median 5.7 pg/mL; CTRS 3.55 3.1 pg; 205.7 155.4 77.12 63.94 pg/mL). Interestingly, also found statistically significant positive hyperactivity symptoms (p-value <0.001). Further investigations larger groups necessary confirm our verify more depth features, such as severity core symptoms, presence associated and/or evaluation therapeutic intervention. However, not only might shed light neurobiology ASD, supporting neurodegeneration hypothesis, but they support use early diagnosis longitudinally monitor disease activity, even future biomarkers.

Language: Английский

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A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(8), P. 101680 - 101680

Published: Aug. 1, 2024

The role of central nervous system (CNS) glia in sustaining self-autonomous inflammation and driving clinical progression multiple sclerosis (MS) is gaining scientific interest. We applied a single transcription factor (SOX10)-based protocol to accelerate oligodendrocyte differentiation from human induced pluripotent stem cell (hiPSC)-derived neural precursor cells, generating self-organizing forebrain organoids. These organoids include neurons, astrocytes, oligodendroglia, hiPSC-derived microglia achieve immunocompetence. Over 8 weeks, reproducibly generated mature CNS types, exhibiting single-cell transcriptional profiles similar the adult brain. Exposed inflamed cerebrospinal fluid (CSF) patients with MS, properly mimic macroglia-microglia neurodegenerative phenotypes intercellular communication seen chronic active MS. Oligodendrocyte vulnerability emerged by day 6 post-MS-CSF exposure, nearly 50% reduction. Temporally resolved organoid data support expand on soluble CSF mediators downstream events leading death inflammatory neurodegeneration. Such findings implementation this model for drug screening halt

Language: Английский

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What are the levels and interactions of neuroligin-1, neuroligin-3, and inflammatory cytokines (IL-6, IL-8) in children diagnosed with autism spectrum disorder?

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111275 - 111275

Published: Jan. 1, 2025

Language: Английский

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Cytomegalovirus-Reactive IgG Correlates with Increased IL-6 and IL-1β Levels, Affecting Eating Behaviours and Tactile Sensitivity in Children with Autism

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 338 - 338

Published: Feb. 2, 2025

Background/Objectives: Elevated cytokine levels, including IL-6 and IL-1β, can contribute to persistent brain inflammation in children with autism cytomegalovirus (CMV) infection, exacerbating autism-related behaviours symptoms. This study evaluates the impact of CMV-induced increases on eating sensory profiles autism. Methods: A cross-sectional design was employed, involving aged two five years (CMV-reactive IgG), ASD (n= 98) TD (n = 96). Serological tests using ELISA were conducted measure IgG CMV, IL-6, IL-1β biomarkers. Eating evaluated BAMBI (Brief Autism Mealtime Behaviour Inventory), assessed SSP (Short Sensory Profile). Statistical analyses performed Spearman’s rank chi-square tests. Results: The results show that significantly affects children’s (p < 0.001), notable differences found between groups. Correlation analysis revealed a significant association CMV 0.026) 0.014) group. Additionally, (food refusal limited variety) correlated IL-1β. characteristics, such as tactile sensitivity, correlate 0.027) 0.002) Conclusions: These findings suggest CMV-infected are at increased risk dysregulation, contributing processing issues behaviours. Further research is needed enhance testing protocols better understand virus’s role development behavioural

Language: Английский

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Discovery of Novel Pain Regulators Through Integration of Cross‐Species High‐Throughput Data

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

Chronic pain is an impeding condition that affects day-to-day life and poses a substantial economic burden, surpassing many other health conditions. This study employs cross-species integrated approach to uncover novel mediators/regulators. We used weighted gene coexpression network analysis identify pain-enriched module. Functional protein-protein interaction (PPI) of the module genes were conducted. RNA sequencing compared model control mice. PheWAS was performed link pain-related GWAS traits. Finally, candidates prioritized based on node degree, differential expression, associations, phenotype correlations. A significantly over-enriched with reference set identified (referred as "pain module"). Analysis revealed 141 interacting 46 in PPI network, which included 88 differentially expressed genes. linked 53 these Expression correlation Vdac1, Add2, Syt2, Syt4 correlated phenotypes across eight brain regions. NCAM1, VAMP2, SYT2, ADD2, KCND3 top response/regulator The molecular mechanisms may enhance understanding pathways contribute better drug target identification.

Language: Английский

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Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Worldwide, donkeys ( Equus asinus ) are valued for their meat and milk, in China also the medical value of skin. Physiological characteristics key to donkey's adaptability, including digestive, respiratory, reproductive systems, which enable them survive work a variety environments. However, understanding donkey physiological at cellular level remains poor. Thus, single‐cell transcriptome sequencing is used construct detailed transcriptional atlas based on 20 tissues from Dezhou (in total 84 cell types 275 050 high quality cells) perform an in‐depth investigation molecular physiology. Cross‐species cross‐tissue comparative analyses reveal SOX10 be evolutionally conserved regulon oligodendrocytes illuminate distinctive patterns sebocytes. Moreover, through multispecies skin metabolomics, highly abundant, species‐specific metabolites identified, such as arachidonic acid gamma‐glutamylcysteine, pivotal role sebocytes metabolism highlighted. In summary, this offers new insights into unique metabolic provides valuable resource conservation germplasm advancement selective breeding programs.

Language: Английский

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Profiling the expression and functional roles of mRNAs and lncRNAs associated with post-stroke aphasia

Frontiers in Molecular Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: April 9, 2025

Post-stroke aphasia (PSA) is one of the primary causes post-stroke impairment, although its underlying mechanism unknown; therefore, this study aimed to identify long non-coding RNAs (lncRNAs) and messenger (mRNAs) linked PSA understand potential processes by which they may operate. RNA sequencing was used determine lncRNA mRNA expression profiles for patients healthy control peripheral blood mononuclear cells. This allowed discovery lncRNAs differentially expressed genes (DElncRNAs DEGs). Gene Ontology (GO) KEGG enrichment analyses were performed on these DElncRNAs DEGs, qPCR confirm their expression. Furthermore, any correlations between characteristics with differential language routines evaluated. In total, comparisons groups yielded 577 892 DEGs. Functional targets demonstrated strong co-expressed DEGs in immune system inflammatory response. The levels CTD-2545M3.2 RP11-24N18.1 mRNAs RPS10 LAIR2 similarly highly connected verbal conduct upon admission. results highlight PSA, demonstrating various methods via influence clinical setting.

Language: Английский

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