International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12238 - 12238
Published: Nov. 14, 2024
The
inability
to
accurately
predict
the
occurrence
of
postoperative
cognitive
dysfunction
(POCD)
among
open-heart
surgery
patients
leads
concerning
increases
in
POCD
cases.
Preoperative
circulating
biomarkers
are
important
identify
as
they
non-invasive
and
could
provide
an
early
prediction
development,
allowing
for
earlier
more
strategized
interventions.
However,
date,
no
robust
have
proven
effective
preoperative
prediction.
This
systematic
review
aims
synthesize
current
evidence
on
protein
profiling
following
surgery.
Thus,
a
thorough
literature
search
employing
PubMed,
EBSCOhost,
Scopus,
Science
Direct
was
carried
out.
combination
keywords
used
part
strategy:
(“Postoperative
decline”
OR
“Postoperative
disorders”
dysfunction”
complications”)
AND
(“Thoracic
Surgery”
“Cardiac
“Heart
Surgery”)
(“Protein
expression”
proteomic
“Protein
profiling”).
Eight
hundred
twenty-nine
studies
were
retrieved
only
clinical
reporting
differentially
expressed
Proteins
(DEPs)
selected.
Six
selected
inclusion
exclusion
criteria.
Only
one
DEP
four
immediate
DEPs
extracted
from
studies.
All
proteins
analysis
using
DAVID,
STRING,
Cytoscape
software.
Due
very
low
number
proteins,
clusters
been
identified.
demonstrates
lack
open-heart-surgery
patients.
it
is
suggested
that
can
be
conducted
fill
this
gap.
Vessel Plus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 11, 2024
The
study
is
focused
on
the
connection
between
cognitive
dysfunction,
inflammatory
processes,
oxidative
stress,
and
various
associated
biological
factors.
Postoperative
dysfunction
a
condition
where
patient
exhibits
temporary
deterioration
in
function
after
surgery,
which
may
include
problems
with
memory,
concentration,
overall
performance.
While
most
common
among
elderly
patients,
it
can
occur
individuals
of
any
age.
causes
are
not
fully
elucidated,
but
assumed
that
peripheral
trauma
during
long-term
surgical
interventions
behind
development
inflammation
creation
conditions
leads
to
disruption
blood-brain
barrier
subsequent
impairment.
This
review
aims
describe
detected
changes
at
level
selected
markers
damage
primarily
cardiac
surgery.
Medicina,
Journal Year:
2024,
Volume and Issue:
60(8), P. 1337 - 1337
Published: Aug. 17, 2024
:
Cardiac
surgery
is
associated
with
various
durations
of
cerebral
autoregulation
(CA)
impairment
and
can
significantly
impact
cognitive
function.
Cognitive
functions
such
as
memory,
psychomotor
speed,
attention
are
impacted
after
cardiac
surgery,
necessitating
prioritization
these
areas
in
function
tests.
There
a
lack
research
connecting
to
specific
domains
surgery.
This
study
aimed
determine
if
impaired
postoperative
memory
test
the
hypothesis
that
duration
this
affects
development
issues.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(9), P. 942 - 942
Published: Sept. 21, 2024
Human
biostasis,
the
preservation
of
a
human
when
all
other
contemporary
options
for
extension
quality
life
are
exhausted,
offers
speculative
potential
survival
via
continuation
in
future.
While
provably
reversible
preservation,
also
known
as
suspended
animation,
is
not
yet
possible
humans,
primary
justification
biostasis
brain,
which
broadly
considered
seat
memories,
personality,
and
identity.
By
preserving
information
contained
within
brain’s
structures,
it
may
be
to
resuscitate
healthy
whole
individual
using
advanced
future
technologies.
There
numerous
challenges
including
inadequacies
current
techniques,
methods
evaluate
revival
In
this
report,
we
describe
roadmap
that
attempts
delineate
research
directions
could
improve
field
focusing
on
optimizing
protocols
establishing
metrics
querying
quality,
well
pre-
post-cardiac
arrest
factors,
stabilization
strategies,
long-term
preservation.
We
acknowledge
highly
theoretical
nature
technologies
importance
achieving
high-fidelity
brain
maximize
repair
plan
update
biennially.
Our
goal
encourage
multidisciplinary
communication
collaboration
field.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(22), P. 12238 - 12238
Published: Nov. 14, 2024
The
inability
to
accurately
predict
the
occurrence
of
postoperative
cognitive
dysfunction
(POCD)
among
open-heart
surgery
patients
leads
concerning
increases
in
POCD
cases.
Preoperative
circulating
biomarkers
are
important
identify
as
they
non-invasive
and
could
provide
an
early
prediction
development,
allowing
for
earlier
more
strategized
interventions.
However,
date,
no
robust
have
proven
effective
preoperative
prediction.
This
systematic
review
aims
synthesize
current
evidence
on
protein
profiling
following
surgery.
Thus,
a
thorough
literature
search
employing
PubMed,
EBSCOhost,
Scopus,
Science
Direct
was
carried
out.
combination
keywords
used
part
strategy:
(“Postoperative
decline”
OR
“Postoperative
disorders”
dysfunction”
complications”)
AND
(“Thoracic
Surgery”
“Cardiac
“Heart
Surgery”)
(“Protein
expression”
proteomic
“Protein
profiling”).
Eight
hundred
twenty-nine
studies
were
retrieved
only
clinical
reporting
differentially
expressed
Proteins
(DEPs)
selected.
Six
selected
inclusion
exclusion
criteria.
Only
one
DEP
four
immediate
DEPs
extracted
from
studies.
All
proteins
analysis
using
DAVID,
STRING,
Cytoscape
software.
Due
very
low
number
proteins,
clusters
been
identified.
demonstrates
lack
open-heart-surgery
patients.
it
is
suggested
that
can
be
conducted
fill
this
gap.
