Cited by Association between gut microbiota and anxiety disorders: a bidirectional two-sample Mendelian randomization study

A Holistic Approach for Ethics and Sustainability in the Food Chain: The Gateway to Oral and Systemic Health DOI

Theodoros Varzakas, Μαρία Αντωνιάδου

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1224 - 1224

Published: April 17, 2024

Food production is a complex matter, affecting people’s lives, organizations’ profits, and the well-being of whole planet, has multifaceted ethical considerations surrounding its production, distribution, consumption. This paper addresses pressing need to confront challenges within food system, encompassing issues such as environmental sustainability, security, individual choices for better oral systemic health all individuals around globe. From agricultural practices global trade waste, implications are addressed across various domains, highlighting interconnectedness decision-making in industry. Central themes explored include dimensions methods, impact on ethics, role making ethically informed choices. Additionally, this considers spiritual physical significance food, particularly through lens gateway holistic well-being. Recognizing complexity mouth ecosystem, calls serious interventions legislation economics promote protocols techniques sustainability reasons. It emphasizes importance safety management systems, regulatory frameworks, quality standards. Moreover, underlines comprehensive approach address dilemmas moral values inherent industry policies, adopting precautionary principle frameworks. article finally aims serve call action stakeholders healthcare sector, prioritize practices, transparency, rearrange economic parameters, work towards more sustainable equitable system inner outer human all.

Language: Английский

Citations

Relationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview DOI

Kai Tao,

Yanling Yuan,

Qinglian Xie

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 471, P. 115111 - 115111

Published: June 12, 2024

Language: Английский

Citations

Association between gut microbiota and anxiety disorders: a bidirectional two-sample mendelian randomization study DOI

Jianbing Li, Changhe Fan, Jiaqi Wang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 27, 2024

Abstract Background There are many articles reporting that the component of intestinal microbiota implies a link to anxiety disorders (AD), and brain-gut axis is also hot topic in current research. However, specific relevance between gut AD uncertain. We aimed investigate causal relationship by using bidirectional Mendelian randomization (MR). Methods Genetic instrumental variable (IV) for were obtained from genome-wide association study (GWAS) involving 18,340 participants. Summary data derived GWAS included 158,565 cases 300,995 controls. applied inverse variance weighted (IVW) method as main analysis. Cochran’s Q values was computed evaluate heterogeneity among IVs. Sensitivity analyses including intercept MR-Egger MR-PRESSO analysis used test horizontal pleiotropy. Result discovered 9 potential connections bacterial traits on genus level AD. Utilizing IVW method, we identified 5 genera exhibited direct correlation with risk AD: Eubacteriumbrachygroup , Coprococcus3 Enterorhabdus Oxalobacter Ruminiclostridium6 . Additionally, found 4 negative Blautia Butyricicoccus Erysipelotrichaceae-UCG003 Parasutterella The associations confirmed sensitivity analyses. Conclusion Our relation parts Further randomized controlled trials crucial elucidate positive effects probiotics their particular protection systems.

Language: Английский

Citations

Oral microbiota and central nervous system diseases: A review DOI

Xiaoxuan Zhang,

Mengmeng Zhong,

Yang Li

et al.

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract Oral microbiota is the second largest microbial colony in body and forms a complex ecological community that influences oral brain health. Impaired homeostasis of can lead to pathological changes, resulting central nervous system (CNS) diseases. However, mechanisms clinical value how microbiome remain unclear. This review summarizes recent findings on role CNS diseases proposes potential approaches understand way communicate. We propose three underlying patterns involving neuroinflammation, neuroendocrine regulation, signaling between also summarize characteristics utilization ischemic stroke, Alzheimer's Parkinson's disease, intracranial aneurysms, mental disorders. Although current are preliminary evidence incomplete, biomarker for diagnosis treatment

Language: Английский

Citations

Oral Cavity is the Gateway to the Body: Role of Oral Health Professionals: A Narrative Review DOI

Parvati Iyer

Journal of the California Dental Association, Journal Year: 2023, Volume and Issue: 51(1)

Published: March 30, 2023

Background The oral cavity is the most important link between human body and external environment well-equipped to protect against invading pathogens. Emerging data on bidirectional relationship health severity of COVID-19 symptoms has prompted us reexamine our role as guardians - true gateway body. Recent studies have shown that microbiome a complex ecological system interactions its residents host cells influence disease. This narrative review elaborates oral-systemic connection from an standpoint discusses future professionals.Methods A PubMed literature search using keywords "Oral Microbiome Diseases" Health" for range ten years 2012-2022 was completed. Meta-Analyses, Reviews, Randomized Control Trials, Clinical books were included in search.Results yielded 6392 results 4287 results.Conclusion Oral professionals need be trained periodically appreciate recent advances this field.Practical Implications deeper understanding impact existing treatment modalities could expand preventing maintaining patients' overall health. Implementing point-of-care salivary diagnostics detect biomarkers non-oral diseases conditions may significant leap toward goal.

Language: Английский

Citations

Association between oral microbiome and five types of respiratory infections: a two-sample Mendelian randomization study in east Asian population DOI

Jiawei He,

Ningfeng Mao,

Wenliang Lyu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

To explore the causal relationship between oral microbiome and specific respiratory infections including tonsillitis, chronic sinusitis, bronchiectasis, bronchitis, pneumonia, assessing impact of genetic variations associated with microbiome.

Language: Английский

Citations

Balancing the Oral–Gut–Brain Axis with Diet DOI

Rebecca Kerstens, Yong Zhi Ng, Sven Pettersson

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3206 - 3206

Published: Sept. 22, 2024

Background: The oral microbiota is the second largest microbial community in humans. It contributes considerably to diversity and health effects, much like gut microbiota. Despite physical chemical barriers separating cavity from gastrointestinal tract, bidirectional transmission occurs between two regions, influencing overall host health. Method: This review explores intricate interplay of oral–gut–brain axis, highlighting pivotal role systemic ageing, how it can be influenced by diet. Results: Recent research suggests a relationship diseases, such as periodontitis, problems, broader significance oral–gut axis well neurological disorders mental Diet influences gut. While certain diets/dietary components improve both health, others, fermentable carbohydrates, promote pathogens while boosting Conclusions: Understanding these dynamics key for promoting healthy through dietary interventions that support mitigate age-related risks.

Language: Английский

Citations

Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes DOI

Stefanie Malan‐Müller, Rebeca Vidal, Esther O’Shea

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 5, 2024

The role of the oral microbiome in mental health has recently been appreciated within proposed oral-brain axis. This study examined structure and composition salivary a large-scale population-based cohort individuals reporting symptoms (n = 306) compared to mentally healthy controls 164) using 16S rRNA sequencing. Mental were evaluated validated questionnaires included depression, anxiety, posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes. Participants also indicated current or previous diagnoses periodontitis, gingivitis. variables influenced overall microbiome. PTSD correlated lower clr-transformed relative abundance Haemophilus sputorum higher Prevotella histicola. P. histicola was positively associated depressive scores negatively psychological quality life. Anxiety diagnosis Neisseria elongate Oribacterium asaccharolyticum. A Shuttleworthia Capnocytophaga evident those who reported clinical periodontitis diagnosis. Higher Eggerthia parainfluenzae abundances psychotherapeutic efficacy. Functional prediction analysis revealed potential for tryptophan metabolism/degradation axis, which confirmed by plasma serotonin levels across symptomatic groups. sheds light on intricate interplay between microbiota, outcomes, metabolism emphasizing need further exploration pave way novel therapeutic interventions predicting response.

Language: Английский

Citations

Stress and mental health symptoms in early pregnancy are associated with the oral microbiome DOI

A.M Alex,

Alytia A. Levendosky, G. Anne Bogat

et al.

BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e301100 - e301100

Published: Jan. 1, 2024

Background Research has revealed associations between microbes of the gastrointestinal tract and stress, anxiety depression in pregnant or postpartum women. While these studies suggest a gut-brain-behaviour axis, no have examined oral cavity relation to maternal mental health. Objective To explore potential oral-brain-behaviour axis related Methods Microbes were measured saliva obtained from 224 second-trimester (mean±SD = 17±2 weeks) women oversampled for stress. Oralome data associated with women’s recent cumulative pregnancy trait state anxiety, symptoms post-traumatic stress disorder (PTSD) symptoms. Covariates explored included age, income, alcohol tobacco use, dental issues physical health problems. Results Pregnant high symptom groups had higher alpha diversity, indicating richness species within samples. Groups low PTSD differed beta reflecting differences community composition. Linear discriminant analysis showed differently abundant versus life depression, PTSD, affected mostly differing by symptom. Notably, members phylum Proteobacteria more Spirochaetes was Members Firmicutes groups. Genus Dialister (previously found be lower gut depressed non-pregnant people) experiencing either symptoms, while genus Eikenella elevated PTSD. Conclusions The microbiome is women, ways different what been people. Clinical implications Understanding microbiome–mental relations may reveal future microbial targets improve psychological well-being.

Language: Английский

Citations

Ethics in the Food Ecosystem from Research to Consumption in Conjunction with Oral Health Significance for Sustainability and Spirituality Purposes—Mouth: The Sacred Gateway DOI

Theodoros Varzakas, Μαρία Αντωνιάδου

Published: April 2, 2024

Keywords: food ecosystem, chain, morality, ethics, oral health, systemic diet habits, spirituality, sustainability

Language: Английский

Citations