Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 29, 2023
Abstract
Background
There
are
many
articles
reporting
that
the
component
of
intestinal
microbiota
implies
a
link
to
anxiety
disorders
(AD),
and
brain-gut
axis
is
also
hot
topic
in
current
research.
However,
specific
relevance
between
gut
AD
uncertain.
We
aimed
investigate
causal
relationship
by
using
bidirectional
Mendelian
randomization
(MR).
Methods
Genetic
instrumental
variable
(IV)
for
were
obtained
from
genome-wide
association
study
(GWAS)
involving
18,340
participants.
Summary
data
derived
GWAS
included
158,565
cases
300,995
controls.
applied
inverse
variance
weighting
(IVW)
method
as
main
analysis.
To
ensure
robustness
results,
we
further
executed
weighted
median
MR-Egger
regression
evaluate
potential
horizontal
pleiotropy.
Result
discovered
16
connections
bacterial
traits
AD.
Utilizing
IVW
method,
identified
7
species
exhibited
direct
correlation
with
risk
AD:
class
Negativicutes
,
genus
Eubacteriumbrachygroup
Coprococcus3
Enterorhabdus
Oxalobacter
Ruminiclostridium6
order
Selenomonadales
.
Additionally,
found
9
negative
Methanobacteria
family
Methanobacteriaceae
Porphyromonadaceae
Blautia
Butyricicoccus
Erysipelotrichaceae-UCG003
Parasutterella
Methanobacteriales
phylum
Proteobacteria
Conclusion
Our
relation
parts
Further
randomized
controlled
trials
crucial
elucidate
protective
effects
probiotics
on
their
particular
protection
systems.
Genes,
Journal Year:
2024,
Volume and Issue:
15(10), P. 1263 - 1263
Published: Sept. 27, 2024
:
A
growing
body
of
research
supports
the
role
microbial
communities
residing
in
digestive
system
host's
cognitive
functioning.
Most
these
studies
have
been
focused
on
gut
microbiome
and
its
association
with
clinical
phenotypes
middle-aged
older
adults.
There
is
an
insufficiency
population-based
exploring
normative
functioning
particularly
oral
microbiota.
The Kaohsiung Journal of Medical Sciences,
Journal Year:
2023,
Volume and Issue:
39(10), P. 1002 - 1010
Published: Oct. 1, 2023
Butyrate
(BU),
a
gut
microbiota-derived
metabolite,
has
been
reported
to
play
neuroprotective
role
in
Parkinson's
disease
(PD).
However,
the
specific
molecular
mechanism
of
BU
not
fully
interpreted.
This
work
aimed
verify
protective
effects
against
MPTP/MPP+
-induced
neurotoxicity
and
explore
mechanisms
involved.
The
results
showed
that
protected
MPTP-induced
motor
dysfunction
decreased
tyrosine
hydroxylase
(TH)
dopamine
transporter
(DAT)
levels.
Additionally,
pretreatment
improved
PC12
cell
viability
reduced
MPP+
apoptosis.
treatment
also
attenuated
-stimulated
oxidative
stress
inflammatory
response
cells.
Furthermore,
inhibited
hyperactivation
JAK2/STAT3
signaling
mice
Besides,
JAK2
agonist,
Coumermycin
A1
(C-A1),
substantially
reversed
BU-mediated
inhibition
on
phosphorylation
-challenged
cells
abated
BU-induced
repression
-triggered
apoptosis,
stress,
To
sum
up,
might
exert
/MPTP-induced
by
inactivating
signaling.
Archives of Physiology and Biochemistry,
Journal Year:
2023,
Volume and Issue:
unknown, P. 1 - 17
Published: Dec. 25, 2023
Since
the
oral
cavity
is
gateway
to
gut,
microbes
likely
hold
potential
influence
metabolic
disease
by
affecting
gut
microbiota.A
thorough
review
of
literature
has
been
performed
link
alterations
in
microbiota
with
chronic
influencing
strong
correlation
exists
between
abnormalities
and
several
systemic
disorders,
such
as
cardiovascular
disease,
diabetes,
obesity,
which
initially
manifest
diseases.
Ensuring
adequate
hygiene
practices
cultivating
diverse
microflora
are
crucial
for
preservation
general
well-being.
Oral
bacteria
have
ability
establish
endure
gastrointestinal
tract,
leading
development
prolonged
inflammation
activation
immune
system.
microbe-associated
prophylactic
strategies
could
be
beneficial
mitigating
diseases.Oral
can
a
profound
impact
on
pathogenesis
Psikhiatriya,
Journal Year:
2024,
Volume and Issue:
22(2), P. 54 - 65
Published: May 23, 2024
Background
:
depression
is
widespread
in
the
population,
and
one
of
leading
causes
disability,
reduced
life
expectancy
mortality.
Such
a
significant
effect
based
on
high
frequency
comorbidity
with
severe
chronic
somatic
diseases.
Genetic
studies
can
provide
tools
to
identify
groups
level
genetic
risk
these
diseases
population
for
their
early
specific
prevention.
The
aim
review
article
was
justify
methodology
design
research
directed
joint
markers
linked
each
other
terms
comorbidity.
Publication,
patients
methods
cohort
depressive
examined
using
international
clinical
psychometric
instruments.
study
will
allow:
1)
evaluate
risks
developing
depression;
2)
assess
predictive
power
polygenic
scores
symptoms
sample;
3)
validate
qualitatively
described
sample
modern
tools.
Conclusion
results
be
used
an
evidence-based
preventive
approach
field
mental
physical
health.
Critical Care Nurse,
Journal Year:
2024,
Volume and Issue:
44(2), P. 49 - 58
Published: April 1, 2024
Introduction
Non–ventilator-associated
hospital-acquired
pneumonia
is
a
preventable
health
care–associated
infection
accounting
for
1
in
14
hospital
deaths.
Clinical
factors
influencing
this
condition
include
oral
and
bacteria
care.
This
case
report
addresses
diagnostics
clinical
variables
related
to
non–ventilator-associated
emphasizes
the
importance
of
prevention.
Findings
A
90-year-old
woman
was
admitted
with
shortness
breath
generalized
weakness
from
new-onset
atrial
fibrillation
suspected
heart
failure
exacerbation.
During
hospitalization,
her
status
declined
bacterial
colonization
shifted,
Neisseria
becoming
most
common
genus
around
time
development
probable
pneumonia.
Diagnosis
The
patient
had
new
respiratory
symptoms
chest
radiograph
positive
on
day
4
subsequently
diagnosed
Interventions
Intravenous
antibiotic
treatment
initiated.
Oral
care
completed
only
2
7
days.
received
limited
ambulation
assistance
encouragement
staff
family
members.
No
dysphagia
screening
documented.
Outcomes
On
6,
discharged
antibiotics
independent
living
facility
home
Conclusions
Consistent
care,
early
frequent
physical
activity,
measures
aimed
reduce
aspiration
risk
are
key
interventions
all
hospitalized
patients
prevent
Further
research
warranted
assess
shifts
general
during
which
could
provide
clinically
meaningful
data
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 31, 2024
Abstract
The
role
of
the
oral
microbiome
in
mental
health
has
recently
been
appreciated
within
proposed
oral-brain
axis.
This
study
examined
structure
and
composition
salivary
a
large-scale
population-based
cohort
individuals
reporting
symptoms
(n
=
306)
compared
to
mentally
healthy
controls
164)
using
16S
rRNA
sequencing.
Mental
were
evaluated
validated
questionnaires
included
depression,
anxiety,
posttraumatic
stress
disorder,
with
accompanying
periodontal
outcomes.
Participants
also
indicated
current
or
previous
diagnoses
periodontitis,
gingivitis.
variables
influenced
overall
microbiome.
PTSD
correlated
reduced
Haemophilus
sputorum
elevated
Prevotella
histicola
levels.
Anxiety
disorder
diagnosis
was
associated
decreased
Neisseria
elongate
increased
Oribacterium
asaccharolyticum.
P.
abundance
positively
depressive
scores
negatively
psychological
quality
life.
A
higher
Shuttleworthia
lower
Capnocytophaga
evident
those
who
reported
clinical
periodontitis
diagnosis.
Functional
prediction
analysis
revealed
potential
for
tryptophan
metabolism/degradation
axis,
which
confirmed
by
plasma
serotonin
levels
across
symptomatic
groups.
Higher
Eggerthia
parainfluenzae
psychotherapeutic
efficacy.
sheds
light
on
intricate
interplay
between
microbiota,
outcomes,
health,
emphasizing
need
further
exploration
axis
pave
way
novel
therapeutic
interventions
predicting
response.
Revista de la Asociación Odontológica Argentina/Revista de la Asociación Odontológica Argentina,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 6
Published: Dec. 30, 2024
La
caries
de
la
primera
infancia
persiste
como
una
enfermedad
mundial
alta
prevalencia
y
profundo
impacto
sobre
calidad
vida
del
niño
su
familia.
El
objetivo
este
trabajo
es
revisión
aspectos
referidos
a
compleja
etiología.
Durante
décadas
dental
fue
descripta
infecciosa
transmisible
con
presencia
Streptococcus
mutans
el
agente
fundamental.
Hoy
se
reconoce
no
transmisible,
prevenible.
Las
actuales
tecnologías
genómicas,
incluida
bioinformática
secuenciación
nueva
generación,
han
aumentado
considerablemente
comprensión
microbioma
bucal
importancia
en
etiopatogenia
enfermedad.
Palabras
clave:
Atención
salud,
dental,
temprana,
niño,
odontología
pediátrica,
susceptibilidad
dental.
//Early
childhood
remains
as
highly
prevalent
global
disease
with
major
impact
on
the
quality
of
life
child
and
their
family.
The
aim
this
work
is
revision
aspectss
related
to
its
complex
etiology.
For
decades,
was
described
an
infectious
transmissible
presence
fundamental
agent.
Today
it
recognized
preventable
non-communicable
disease.
Current
genomic
technologies,
including
bioinformatics
next-generation
sequencing,
have
considerably
increased
understanding
oral
microbiome
importance
in
etiopathogenesis
Key
words:
Child,
caries,
early
health
care,
pediatric
dentistry,
susceptibility
caries.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 29, 2023
Abstract
Background
There
are
many
articles
reporting
that
the
component
of
intestinal
microbiota
implies
a
link
to
anxiety
disorders
(AD),
and
brain-gut
axis
is
also
hot
topic
in
current
research.
However,
specific
relevance
between
gut
AD
uncertain.
We
aimed
investigate
causal
relationship
by
using
bidirectional
Mendelian
randomization
(MR).
Methods
Genetic
instrumental
variable
(IV)
for
were
obtained
from
genome-wide
association
study
(GWAS)
involving
18,340
participants.
Summary
data
derived
GWAS
included
158,565
cases
300,995
controls.
applied
inverse
variance
weighting
(IVW)
method
as
main
analysis.
To
ensure
robustness
results,
we
further
executed
weighted
median
MR-Egger
regression
evaluate
potential
horizontal
pleiotropy.
Result
discovered
16
connections
bacterial
traits
AD.
Utilizing
IVW
method,
identified
7
species
exhibited
direct
correlation
with
risk
AD:
class
Negativicutes
,
genus
Eubacteriumbrachygroup
Coprococcus3
Enterorhabdus
Oxalobacter
Ruminiclostridium6
order
Selenomonadales
.
Additionally,
found
9
negative
Methanobacteria
family
Methanobacteriaceae
Porphyromonadaceae
Blautia
Butyricicoccus
Erysipelotrichaceae-UCG003
Parasutterella
Methanobacteriales
phylum
Proteobacteria
Conclusion
Our
relation
parts
Further
randomized
controlled
trials
crucial
elucidate
protective
effects
probiotics
on
their
particular
protection
systems.
