Adipositaschirurgie (Bariatrische Chirurgie) DOI
Hans‐Peter Kapfhammer

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 391 - 472

Published: Jan. 1, 2023

Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial DOI Creative Commons
M Pietrzak, Adam Yngve, J. Paul Hamilton

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(6), P. 1042 - 1049

Published: Feb. 26, 2024

Abstract The stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved the stress response, neuropsychiatric conditions, alcohol drug use disorders. Mechanisms related reward processing might mediate ghrelin’s broader effects on complex behaviors, as indicated by animal studies mostly correlative human studies. Here, using within-subject double-blind placebo-controlled design with intravenous infusion healthy volunteers ( n = 30), we tested whether alters sensitivity punishment learning task. Parameters were derived from computational model of participants’ task behavior. reversal monetary rewards was performed during functional brain imaging investigate signals prediction errors. Compared placebo, decreased t −2.448, p 0.021), while unaltered 0.8, 0.43). We furthermore found increased prediction-error activity dorsal striatum administration (region interest analysis: t- values ≥ 4.21, -values ≤ 0.044). Our results support for that extends beyond food-related rewards. Reduced negative outcomes errors may beneficial food foraging when hungry could relate risk taking impulsivity context addictive behaviors.

Language: Английский

Citations

9

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner DOI Creative Commons

Amy J. Pearl,

Xavier J. Maddern,

Paulo Pinares-Garcia

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 15, 2025

Abstract Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus emerged key regulator of alcohol consumption. Here we found that EWcp peptidergic cells reduce binge specifically female mice. We show this effect is mediated by the ghrelin receptor (GHSR), with inhibition blocking ghrelin-induced and Ghsr knockdown , but not glutamatergic or ventral tegmental area cells, reducing females, independent circulating hormones. Female mice showed higher expression, neurons were more sensitive to ghrelin. Moreover, intra-EWcp delivery GHSR inverse agonist antagonist reduced drinking, suggesting direct actions These findings highlight critical mediator excessive consumption via mice, offering insights into system’s role

Language: Английский

Citations

1

A Complex Interplay between Nutrition and Alcohol use Disorder: Implications for Breaking the Vicious Cycle DOI
Brooke White, Sunil Sirohi

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(23), P. 1822 - 1837

Published: May 27, 2024

Approximately 16.5% of the United States population met diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol (AUD). Individuals AUD are at increased risk malnutrition, and impairments nutritional status chronic users can be detrimental to physical emotional well-being. Furthermore, these deficiencies could contribute never-ending cycle alcoholism related pathologies, thereby jeopardizing prospects recovery treatment outcomes. Improving patients may not only compensate general malnutrition but also reduce adverse symptoms during recovery, promoting abstinence successful AUD. In this review, we briefly summarize alterations people addictive disorders, addition underlying neurobiological mechanisms clinical implications regarding role intervention from disorder.

Language: Английский

Citations

4

GHSR blockade, but not reduction of peripherally circulating ghrelin via β1-adrenergic receptor antagonism, decreases binge-like alcohol drinking in mice DOI Creative Commons

Rani Richardson,

Lindsay A Kryszak,

Janaina C. M. Vendruscolo

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 5, 2024

Language: Английский

Citations

4

Contribution of Visceral Systems to the Development of Substance Use Disorders: Translational Aspects of Interaction between Central and Peripheral Mechanisms DOI Creative Commons
Д. И. Перегуд, N. V. Gulyaeva

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(11), P. 1868 - 1888

Published: Nov. 1, 2024

Language: Английский

Citations

2

Edinger-Westphal ghrelin receptor signalling regulates binge alcohol consumption in a sex specific manner DOI Creative Commons

Amy Pearl,

Paulo Pinares-Garcia,

Arnav Shesham

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

Abstract Background Rates of risky drinking are continuing to rise, particularly in women, yet sex as a biological variable has been largely ignored. An emerging understudied potential component this circuitry is the central projecting Edinger-Westphal (EWcp), which made up two prominent, but distinct cell populations expressing either an array neuropeptides (including cocaine and amphetamine regulated transcript; CART) or vGlut2 (glutamatergic). Methods Here, we use combination approaches including genetic, molecular biology, behavioural testing, electrophysiology understand how EWcp contributes alcohol consumption female versus male mice. Results Chemogenetic inhibition CART cells reduced binge specifically female, not Further, prevented ghrelin induced drinking, viral–mediated receptor ( Ghsr ) knockdown RNAscope revealed expression across peptidergic (marked by glutamatergic EWcp, with neurons from mice more sensitive bath application than Targeted GHSR signalling on peptidergic, mediate Finally, both inverse agonist antagonist delivered directly within Conclusions These findings suggest region mediating excessive bingeing through actions (CART-expressing) expand our understanding neural mechanism(s) underpinning system mediates consumption.

Language: Английский

Citations

1

Emerging pharmacological targets for alcohol use disorder DOI Creative Commons

Dakota F. Brockway,

Nicole A. Crowley

Alcohol, Journal Year: 2024, Volume and Issue: 121, P. 103 - 114

Published: July 26, 2024

Alcohol Use Disorder (AUD) remains a challenging condition with limited effective treatment options; however new technology in drug delivery and advancements pharmacology have paved the way for discovery of novel therapeutic targets. This review explores emerging pharmacological targets that offer options management AUD, focusing on potential somatostatin (SST), vasoactive intestinal peptide (VIP), glucagon-like peptide-1 (GLP-1), nociceptin (NOP), neuropeptide S (NPS). These been selected based recent preclinical clinical research, which suggest their significant roles modulating alcohol consumption related behaviors. SST dampens cortical circuits, targeting both neurons itself presents promise treating AUD various comorbidities. VIP are modulated by system an unexplored avenue addressing exposure at stages development. GLP-1 interacts dopaminergic reward reduces intake. Nociceptin modulates mesolimbic circuitry agonism antagonism receptor offers complex but promising approach to reducing consumption. NPS stands out its anxiolytic-like effects, particularly relevant anxiety associated AUD. aims synthesize current understanding these targets, highlighting developing more personalized therapies, underscores importance continued research identifying validating comorbid conditions.

Language: Английский

Citations

1

Early-Stage Moderate Alcohol Feeding Dysregulates Insulin-Related Metabolic Hormone Expression in the Brain: Potential Links to Neurodegeneration Including Alzheimer’s Disease DOI Creative Commons
Yiwen Yang, Ming Tong, Suzanne M. de la Monte

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 1211 - 1228

Published: July 13, 2024

Background: Alzheimer’s disease (AD), one of the most prevalent causes dementia, is mainly sporadic in occurrence but driven by aging and other cofactors. Studies suggest that excessive alcohol consumption may increase AD risk. Objective: Our study examined degree to which short-term moderate ethanol exposure leads molecular pathological changes AD-type neurodegeneration. Methods: Long Evans male female rats were fed for 2 weeks with isocaloric liquid diets containing 24% or 0% caloric ( n = 8/group). The frontal lobes used measure immunoreactivity biomarkers, insulin-related endocrine metabolic molecules, proinflammatory cytokines/chemokines duplex multiplex enzyme-linked immunosorbent assays (ELISAs). Results: Ethanol significantly increased lobe levels phospho-tau, reduced Aβ, ghrelin, glucagon, leptin, PAI, IL-2, IFN- γ. Conclusions: Short-term effects chronic feeding produced neuroendocrine pathologic reflective dysregulation, together abnormalities likely contribute impairments neuroplasticity. findings rapidly establishes a platform energy metabolism occur both early stages alcohol-related brain degeneration.

Language: Английский

Citations

1

Adipositaschirurgie (Bariatrische Chirurgie) DOI
Hans‐Peter Kapfhammer

Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 391 - 472

Published: Jan. 1, 2023

Citations

0