Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 391 - 472
Published: Jan. 1, 2023
Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(6), P. 1042 - 1049
Published: Feb. 26, 2024
Abstract The stomach-derived hormone ghrelin plays not only a role in feeding, starvation, and survival, but it has been suggested to also be involved the stress response, neuropsychiatric conditions, alcohol drug use disorders. Mechanisms related reward processing might mediate ghrelin’s broader effects on complex behaviors, as indicated by animal studies mostly correlative human studies. Here, using within-subject double-blind placebo-controlled design with intravenous infusion healthy volunteers ( n = 30), we tested whether alters sensitivity punishment learning task. Parameters were derived from computational model of participants’ task behavior. reversal monetary rewards was performed during functional brain imaging investigate signals prediction errors. Compared placebo, decreased t −2.448, p 0.021), while unaltered 0.8, 0.43). We furthermore found increased prediction-error activity dorsal striatum administration (region interest analysis: t- values ≥ 4.21, -values ≤ 0.044). Our results support for that extends beyond food-related rewards. Reduced negative outcomes errors may beneficial food foraging when hungry could relate risk taking impulsivity context addictive behaviors.
Language: Английский
Citations
9
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 15, 2025
Abstract Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus emerged key regulator of alcohol consumption. Here we found that EWcp peptidergic cells reduce binge specifically female mice. We show this effect is mediated by the ghrelin receptor (GHSR), with inhibition blocking ghrelin-induced and Ghsr knockdown , but not glutamatergic or ventral tegmental area cells, reducing females, independent circulating hormones. Female mice showed higher expression, neurons were more sensitive to ghrelin. Moreover, intra-EWcp delivery GHSR inverse agonist antagonist reduced drinking, suggesting direct actions These findings highlight critical mediator excessive consumption via mice, offering insights into system’s role
Language: Английский
Citations
1
Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(23), P. 1822 - 1837
Published: May 27, 2024
Approximately 16.5% of the United States population met diagnostic criteria for substance use disorder (SUD) in 2021, including 29.5 million individuals with alcohol (AUD). Individuals AUD are at increased risk malnutrition, and impairments nutritional status chronic users can be detrimental to physical emotional well-being. Furthermore, these deficiencies could contribute never-ending cycle alcoholism related pathologies, thereby jeopardizing prospects recovery treatment outcomes. Improving patients may not only compensate general malnutrition but also reduce adverse symptoms during recovery, promoting abstinence successful AUD. In this review, we briefly summarize alterations people addictive disorders, addition underlying neurobiological mechanisms clinical implications regarding role intervention from disorder.
Language: Английский
Citations
4
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 5, 2024
Language: Английский
Citations
4
Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(11), P. 1868 - 1888
Published: Nov. 1, 2024
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 27, 2024
Abstract Background Rates of risky drinking are continuing to rise, particularly in women, yet sex as a biological variable has been largely ignored. An emerging understudied potential component this circuitry is the central projecting Edinger-Westphal (EWcp), which made up two prominent, but distinct cell populations expressing either an array neuropeptides (including cocaine and amphetamine regulated transcript; CART) or vGlut2 (glutamatergic). Methods Here, we use combination approaches including genetic, molecular biology, behavioural testing, electrophysiology understand how EWcp contributes alcohol consumption female versus male mice. Results Chemogenetic inhibition CART cells reduced binge specifically female, not Further, prevented ghrelin induced drinking, viral–mediated receptor ( Ghsr ) knockdown RNAscope revealed expression across peptidergic (marked by glutamatergic EWcp, with neurons from mice more sensitive bath application than Targeted GHSR signalling on peptidergic, mediate Finally, both inverse agonist antagonist delivered directly within Conclusions These findings suggest region mediating excessive bingeing through actions (CART-expressing) expand our understanding neural mechanism(s) underpinning system mediates consumption.
Language: Английский
Citations
1
Alcohol, Journal Year: 2024, Volume and Issue: 121, P. 103 - 114
Published: July 26, 2024
Alcohol Use Disorder (AUD) remains a challenging condition with limited effective treatment options; however new technology in drug delivery and advancements pharmacology have paved the way for discovery of novel therapeutic targets. This review explores emerging pharmacological targets that offer options management AUD, focusing on potential somatostatin (SST), vasoactive intestinal peptide (VIP), glucagon-like peptide-1 (GLP-1), nociceptin (NOP), neuropeptide S (NPS). These been selected based recent preclinical clinical research, which suggest their significant roles modulating alcohol consumption related behaviors. SST dampens cortical circuits, targeting both neurons itself presents promise treating AUD various comorbidities. VIP are modulated by system an unexplored avenue addressing exposure at stages development. GLP-1 interacts dopaminergic reward reduces intake. Nociceptin modulates mesolimbic circuitry agonism antagonism receptor offers complex but promising approach to reducing consumption. NPS stands out its anxiolytic-like effects, particularly relevant anxiety associated AUD. aims synthesize current understanding these targets, highlighting developing more personalized therapies, underscores importance continued research identifying validating comorbid conditions.
Language: Английский
Citations
1
Journal of Alzheimer s Disease Reports, Journal Year: 2024, Volume and Issue: 8(1), P. 1211 - 1228
Published: July 13, 2024
Background: Alzheimer’s disease (AD), one of the most prevalent causes dementia, is mainly sporadic in occurrence but driven by aging and other cofactors. Studies suggest that excessive alcohol consumption may increase AD risk. Objective: Our study examined degree to which short-term moderate ethanol exposure leads molecular pathological changes AD-type neurodegeneration. Methods: Long Evans male female rats were fed for 2 weeks with isocaloric liquid diets containing 24% or 0% caloric ( n = 8/group). The frontal lobes used measure immunoreactivity biomarkers, insulin-related endocrine metabolic molecules, proinflammatory cytokines/chemokines duplex multiplex enzyme-linked immunosorbent assays (ELISAs). Results: Ethanol significantly increased lobe levels phospho-tau, reduced Aβ, ghrelin, glucagon, leptin, PAI, IL-2, IFN- γ. Conclusions: Short-term effects chronic feeding produced neuroendocrine pathologic reflective dysregulation, together abnormalities likely contribute impairments neuroplasticity. findings rapidly establishes a platform energy metabolism occur both early stages alcohol-related brain degeneration.
Language: Английский
Citations
1
Springer eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 391 - 472
Published: Jan. 1, 2023
Citations
0