Cannabinoid CB1 receptor-sensitive neurodevelopmental processes and trajectories

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract As high-potency cannabis (with high Δ 9 -Tetrahydrocannabinol content) becomes easily accessible and widespread, it is of extreme importance for public health that a scientific platform used to implement practical guidelines, particularly at-risk populations. Many reviews have been written in the past decade summarizing impact developing brain. One critical concept frequently mentioned but not discussed detail whether there are sensitive neurodevelopmental events driving age-specific sensitivity cannabis, those mediated by cannabinoid type 1 receptor signaling. By integrating available data from humans animal models, goal present expert review article provide mechanistic overview on how exposure during periods neural circuit plasticity development can result lasting consequences. Here we frontal cortex as proxy align trajectory brain system between rodents. Both strengths limitations studies effects cannabinoids were using developmental framework which adaptations considered. Such an approach needed key variables through lifespan, turn will valuable insights applicable human defining underpinning mechanisms changes childhood adolescence, thereafter young adulthood.

Language: Английский

Cannabis for medicine and food: A benefit vs risk critical appraisal

South African Journal of Botany, Journal Year: 2024, Volume and Issue: 175, P. 15 - 31

Published: Oct. 11, 2024

Language: Английский