Menopause-Associated Depression: Impact of Oxidative Stress and Neuroinflammation on the Central Nervous System—A Review

Biomedicines, Journal Year: 2024, Volume and Issue: 12(1), P. 184 - 184

Published: Jan. 15, 2024

Perimenopausal depression, occurring shortly before or after menopause, is characterized by symptoms such as emotional anxiety, and stress, often accompanied endocrine dysfunction, particularly hypogonadism senescence. Current treatments for perimenopausal depression primarily provide symptomatic relief but come with undesirable side effects. The development of agents targeting the specific pathologies has been relatively slow. erratic fluctuations in estrogen progesterone levels during stage expose women to risk developing perimenopausal-associated depression. These hormonal changes trigger production proinflammatory mediators induce oxidative leading progressive neuronal damage. This review serves a comprehensive overview underlying mechanisms contributing It aims shed light on complex relationship between hormones, neurotransmitters, brain-derived neurotrophic factors, chronic inflammation, By summarizing intricate interplay fluctuations, neurotransmitter activity, this stimulate further research field. hope that an increased understanding these will pave way more effective therapeutic targets, ultimately reducing menopausal betterment psychological wellbeing.

Language: Английский

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Understanding the Biological Relationship between Migraine and Depression

Biomolecules, Journal Year: 2024, Volume and Issue: 14(2), P. 163 - 163

Published: Jan. 30, 2024

Migraine is a highly prevalent neurological disorder. Among the risk factors identified, psychiatric comorbidities, such as depression, seem to play an important role in its onset and clinical course. Patients with migraine are 2.5 times more likely develop depressive disorder; this becomes even higher patients suffering from chronic or aura. This relationship bidirectional, since depression also predicts earlier/worse of migraine, increasing chronicity and, consequently, requiring healthcare expenditure compared alone. All these data suggest that may share overlapping biological mechanisms. Herein, review explores topic further detail: firstly, by introducing common epidemiological for comorbidity; secondly, focusing on providing cumulative evidence aspects, particular emphasis serotoninergic system, neuropeptides calcitonin-gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), substance P, neuropeptide Y orexins, sexual hormones, immune system; lastly, remarking future challenges required elucidate etiopathological mechanisms updated information regarding new key targets pharmacological treatment entities.

Language: Английский

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A meta-analysis on the incidence rate of depression in Chinese menopausal women

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 19, 2025

To systematically evaluate the incidence rate of depressive symptoms in Chinese menopausal women. Six major English databases including PubMed, EBSCO, Scopus, Web Science, X-MOL, Springer, and three WanFang, CNKI, VIP were retrieved to collect all observational studies on morbidity depression women published as May 10, 2024. Use US Healthcare Research Quality (AHRQ) tests assess quality individual studies. For aggregation effect sizes, a random effects model was adopted. Funnel plot, Begg's test Egger's adopted determine publication bias. Subgroup analysis sensitivity applied explore heterogeneity summary estimation. After thorough search, 22 discovered meet criteria included this meta-analysis. The comprehensive estimation using 32% (95% confidence interval: 28–36, I2 = 100%). When visually inspecting funnel interpreting (p 0.101 > 0.05) 0.176 0.05), there no According our records, among 32%. results indicated that China, relatively high. It is essential take notice screening population soon possible actively adopt prevention treatment measures for depression. This has important public health significance identifying high-risk groups patients, improving prognosis. PROSPERO ( york.ac.uk ), Identifier CRD42024542320.

Language: Английский

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Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4231 - 4231

Published: Sept. 30, 2023

The menopausal transition is often accompanied with distressing manifestations, such as vasomotor symptoms, sleep disruptions, and depressive syndrome. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have emerged a potential intervention to alleviate these symptoms. This review aimed comprehensively assess the impact of n-3 PUFAs supplementation on quality, depression among postmenopausal women. We conducted systematic literature search randomized controlled trials across Cochrane Library, Web Science, PubMed, CINAHL, EMBASE, SCOPUS databases from inception August 2023. Among initial pool 163 identified studies, nine studies met inclusion criteria were incorporated into this review. Notably, four detected benefits in improving hot flashes night sweats. On contrary, quality outcomes displayed heterogeneity studies. Incorporating diverse scales, Hamilton Depression Rating Scale-21, Patient Health Questionnaire scale, Generalized Anxiety Disorder-7 for outcomes, we found inconclusive evidence PUFA’s depression. Overall, combined analysis did not provide substantial support efficacy Further well-designed clinical larger participant groups are crucial validate generalize results. Review Registration: PROSPERO registration no: CRD42023421922.

Language: Английский

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Untargeted Metabolomics Revealed that Quercetin Inhibited Ferroptosis by Improving Metabolic Disorder in the Hippocampus of Perimenopausal Depression Model Rats

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 24, 2024

Language: Английский

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Metabolomics revealed that quercetin improved spleen metabolism disorders and regulated the brain-spleen axis in perimenopausal depression model rats

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2025, Volume and Issue: 258, P. 116744 - 116744

Published: Feb. 13, 2025

Language: Английский

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RELAÇÃO ENTRE OS HORMÔNIOS DA PERIMENOPAUSA, NEUROTRANSMISSORES E DEPRESSÃO: REVISÃO SISTEMÁTICA

Revista Contemporânea, Journal Year: 2025, Volume and Issue: 5(3), P. e7609 - e7609

Published: March 5, 2025

A razão pela qual as mulheres na perimenopausa são propensas a depressão não é clara, o que pode estar relacionado vários fatores. Em vista disso, objetivou-se sumarizar evidências emergentes sobre complexa relação entre os hormônios esteroides sexuais da perimenopausa, neurotransmissores e (PMD). Para tanto, considerou-se pertinente realização de uma revisão sistemática literatura nas bases dados MEDLINE, Elsevier LILACS, no período 2019-2024. Foram selecionados 13 pesquisas originais cujos resultados mostraram embora ciclos menstruais continuem durante maior parte irregulares, com picos declínios substancialmente maiores mais erráticos do dos principais anos reprodutivos; níveis plasmáticos estrogênio atingem um patamar estável, porém baixo, aumento persistente hormônio folículo-estimulante (FSH) luteinizante (LH). Demonstrou-se estradiol atuar como inibidor monoamina oxidase (MAO-A), sendo essa enzima responsável por catabolizar dopamina (DA), norepinefrina (NE) 5-hidroxitriptamina (5-HT, serotonina). Logo, ao haver deficiência estradiol, estará ativa e, consequentemente, promoverá degradação neurotransmissores, ocasionando, portanto, distúrbio humor. Por conta desta evidência, considera-se imprescindível, tendo em número nos próximos anos, desenvolvimento estudos tema, modo só investigar transtorno humor, mas desenvolver abordagens clínicas terapêuticas sucesso.

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Psychological Changes at Menopause: Anxiety, Mood Swings, and Sexual Health in the Biopsychosocial Context

Journal of Psychosexual Health, Journal Year: 2025, Volume and Issue: 7(1), P. 11 - 14

Published: Jan. 1, 2025

Language: Английский

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The neurobiology of plant-based therapeutics in women's reproductive health: mechanisms, efficacy, and clinical translation

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 20, 2025

This review examines the neurobiological mechanisms by which plant-derived compounds influence women's reproductive health through neuroendocrine-reproductive axis. Gynecological disorders frequently present with neurological manifestations, including cognitive decline in perimenopause, anxiety and depression polycystic ovary syndrome (PCOS), central sensitization endometriosis. Bioactive from medicinal plants, polyphenols phytoestrogens, demonstrate therapeutic potential their anti-inflammatory, antioxidant, neuromodulatory properties. These multi-target offer advantages over conventional single-target therapies simultaneously regulating multiple physiological processes. The explores applications specific gynecological conditions discusses development of dietary supplements functional foods incorporating these ingredients. growing market for products presents opportunities innovative formulations enhanced bioavailability personalized approaches. Future research directions include integrating neuroimaging herbal research, improving clinical translation, establishing regulatory frameworks global application interventions to enhance female health.

Language: Английский

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Targeted Research and Treatment Implications in Women With Depression

FOCUS The Journal of Lifelong Learning in Psychiatry, Journal Year: 2025, Volume and Issue: 23(2), P. 141 - 155

Published: April 1, 2025

Women with a history of traumatic experience, particularly adversity encountered during childhood, have an increased risk developing depression. The authors review the biological mechanisms associating trauma depression, including role hypothalamic-pituitary-adrenal axis. Additionally, psychosocial and cultural considerations experience depression are discussed, current gaps in knowledge about mechanisms, factors, aspects relating to that remain be addressed described. also at for engaging suicidal behaviors, ideation attempts. Increased suicidality women has been observed various populations, among victims intimate partner violence, female veterans, refugees, individuals who identify as lesbian, gay, bisexual, transgender, queer or questioning, other. Although associations between well documented, limited research examined impact age reproductive stage, important area future research. A wide range biological, psychosocial, factors can increase across lifespan described, how they may included when completing clinical assessments is highlighted. Machine learning, its use outcome prediction stages toward individualized psychiatric services, introduced, directions reviewed.

Language: Английский

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