Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14
Published: Oct. 3, 2023
The second part of this paper builds upon and expands the epigenomic-aging perspective presented in Part 1 to describe metabolomic immunomic bases changes then considers some detail application these insights neurotoxicity, neuronal epigenotoxicity, synaptopathy. Cannabinoids are well-known have bidirectional immunomodulatory activities on numerous parts immune system. Immune perturbations impact aging process, epigenome, intermediate metabolism. also metabolism via many pathways. Metabolism directly impacts immune, genetic, epigenetic processes. Synaptic activity, synaptic pruning, and, thus, sculpting neural circuits based metabolic, epigenomic networks at synapse, around cell body. Many neuropsychiatric disorders including depression, anxiety, schizophrenia, bipolar affective disorder, autistic spectrum disorder been linked with cannabis. Therefore, it is important consider features their complex interrelationships reaching a comprehensive understanding cannabinoid dependence. Together findings indicate that immunome metabolome alongside well-recognized genomic understand interdependence interconnectedness appreciation true nature pathophysiology. For reasons, pathophysiology necessitates coordinated multiomics investigation genome-epigenome-transcriptome-metabolome-immunome, chromatin conformation, 3D nuclear architecture which therefore form proper mechanistic underpinning for major new concerning epidemiological relating cannabis exposure.
Language: Английский