Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment DOI Creative Commons
Li‐Yu Hu, Jianxiang Chen, Xinbei Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 17, 2024

Background Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, diagnoses mainly dependent behavioral assessments. Methods In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 (svMCI+D) and 16 without (svMCI-D), along normal controls (NC). The study used the fraction amplitude low-frequency fluctuations (fALFF), functional connectivity, correlation analyses, support vector machine (SVM) techniques. Results fALFF right cerebellum (CERE.R) differed among svMCI+D, svMCI-D, NC groups. Specifically, regional mean CERE. R was lower svMCI-D compared to but higher svMCI+D patients. Moreover, adjusted showed significant Montreal Cognitive Assessment (MOCA) scores orbital part superior frontal gyrus significantly correlated Hamilton Depression Scale whereas postcingulate cortex (PCC.R) MOCA Furthermore, RSFC between PCC. precuneus, as well lingual (LING.R), reduced NC. PreCUN. R, LING. decreased increased svMCI-D. Further SVM analyses achieved good performances, an area under curve (AUC) 0.82 for classifying NC; 0.96 svMCI-D; 0.92 Conclusion revealed disruptive effects impairment, both complementary spontaneous activity svMCI. these findings suggest that identified features might serve potential biomarkers distinguishing NC, thereby guiding clinical treatments such transcranial magnetic stimulation

Language: Английский

Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review DOI Creative Commons
G Negro, Michele Rossi, Camillo Imbimbo

et al.

Frontiers in Dementia, Journal Year: 2025, Volume and Issue: 4

Published: Jan. 29, 2025

Introduction Behavioral and Psychological Symptoms of Dementia (BPSD) are common neuropsychiatric manifestations that complicate the clinical course dementia impact caregiving. Among these, Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation (HIDA) Psychosis (P) domains particularly challenging to manage. Despite their prevalence, underlying mechanisms neuropathological correlates, remain poorly understood. This systematic review aims elucidate basis HIDA psychosis domains, exploring whether distinct proteinopathies neural circuit dysfunctions associated with these symptoms. Methods The follows PRISMA guidelines, a search conducted across MEDLINE, CENTRAL, EMBASE databases. Inclusion criteria involved studies neuropathology in individuals dementia. Records were screened using PICO software, data quality was assessed Newcastle-Ottawa Scale (NOS) CARE guidelines. A narrative synthesis due heterogeneity data. Results From 846 records identified, 37 met inclusion criteria. Of 18,823 cases analyzed, most diagnoses Alzheimer's Disease (83.44%), Lewy Bodies (5.37%), Frontotemporal (13.40%). HIDA-P symptoms distributed all diagnoses, agitation (14.00%), delusions (11.60%), disinhibition (7.61%), hallucinations (6.83%) being frequently reported behaviors. primary diagnosis Neuropathologic Change (ADNC), present predominantly intermediate severe forms. analysis revealed co-occurrence multiple proteinopathies, TAUopathy, TDP-43 pathology, Lewy-related pathology (LRP), latter, association ADNC, 15 studies. Discussion linked overlapping involvement different circuits, amygdala broader limbic system. Evidence suggests TAUopathy key brain regions, such as amygdala, central development In contrast, contribution beta-amyloid vascular damage appears marginal genesis psychotic No behavioral symptom is pathognomonic specific proteinopathy; rather, topography severity lesions plays more decisive role than single molecular composition. Systematic registration INPLASY2024100082.

Language: Английский

Citations

0
Neuroanatomical correlates and predictors of psychotic symptoms in Alzheimer’s disease: a systematic review and meta-analysis DOI Creative Commons
Sara Scarfo,

Antonella M A Marsella,

Loulouda Grigoriadou

et al.

Neuropsychologia, Journal Year: 2024, Volume and Issue: 204, P. 109006 - 109006

Published: Sept. 24, 2024

Language: Английский

Citations

1
A comparative meta-analysis of structural magnetic resonance imaging studies and gene expression profiles revealing the similarities and differences between late life depression and mild cognitive impairment DOI Creative Commons
Ling Zhao,

Lijing Niu,

Haowei Dai

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 25, 2024

Abstract Background Late-life depression (LLD) predisposes individuals to cognitive decline, often leading misdiagnoses as mild impairment (MCI). Voxel-based morphometry (VBM) can distinguish the profiles of these disorders according gray matter (GM) volumes. We integrated findings from previous VBM studies for comparative analysis and extended research into molecular facilitate inspection intervention. Methods comprehensively searched PubMed Web Science that compared LLD MCI cases with matched healthy controls (HCs) inception 31st December 2023. included 13 on (414 LLDs, 350 HCs) 50 (1878 MCIs, 2046 HCs). Seed-based d Mapping Permutation Subject Images (SDM-PSI) was used voxel-based meta-analysis assess GM atrophy, spatially correlated neuropsychological profiles. then multimodal linear-model similarities differences in volumetric changing patterns. Partial least squares (PLS) regression gene enrichment were employed transcription-neuroimaging associations. Results volumes left hippocampus right parahippocampal gyrus are more affected MCI, along memory impairment. a extensive reduction levels neurotransmitters severe downregulation genes related cellular potassium ion transport metal transmembrane transporter activity. Conclusion Compared LLD, exhibited atrophy lower expression transport. Our provided imaging-transcriptomic-genetic integrative differential diagnosis precise intervention between MCI.

Language: Английский

Citations

1
Limbic Network Derangement Mediates Unawareness of Apathy in Mild Cognitive Impairment due to Alzheimer’s Disease: Clues from [18F]FDG PET Voxel-Wise Analysis DOI
Wendy Kreshpa,

Stefano Raffa,

Nicola Girtler

et al.

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 101(2), P. 475 - 485

Published: Sept. 3, 2024

Background: Discrepancy between caregiver and patient assessments of apathy in mild cognitive impairment (MCI) is considered an index unawareness, independently predicting progression to AD dementia. However, its neural underpinning are uninvestigated. Objective: To explore the [18F]FDG PET-based metabolic correlates unawareness measured through discrepancy self-report, patients diagnosed with MCI. Methods: We retrospectively studied 28 intermediate or high likelihood MCI-AD, progressed dementia over average two years, whose degree was evaluated by means Apathy Evaluation Scale (AES) for both (PT-AES) caregivers (CG-AES). Voxel-based analysis at baseline used obtain distinct volumes interest (VOIs) correlated PT-AES, CG-AES, their absolute difference (DISCR-AES). The resulting DISCR-AES VOI count densities were as covariates inter-regional correlation (IRCA) MCI-AD a group matched healthy controls (HC). Results: negatively metabolism bilateral parahippocampal gyrus, posterior cingulate cortex, thalamus, PT-AES score frontal anterior areas, while there no significant CG-AES brain metabolism. IRCA revealed that exhibited reduced metabolic/functional correlations right gyrus projections compared HC. Conclusions: entails early disruption limbic circuitry rather than classical frontal-subcortical pathways typically associated apathy. This reaffirms independent measure marked pathophysiological alterations.

Language: Английский

Citations

0
Neurocognitive Latent Space Regularization for Multi-label Diagnosis from MRI DOI

Jocasta Manasseh-Lewis,

Felipe Godoy,

Wei Peng

et al.

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 185 - 195

Published: Oct. 17, 2024

Language: Английский

Citations

0
Disruptive and complementary effects of depression symptoms on spontaneous brain activity in the subcortical vascular mild cognitive impairment DOI Creative Commons
Li‐Yu Hu, Jianxiang Chen, Xinbei Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 17, 2024

Background Although depression symptoms are commonly reported in patients with subcortical vascular mild cognitive impairment (svMCI), their impact on brain functions remains largely unknown, diagnoses mainly dependent behavioral assessments. Methods In this study, we analyzed resting-state fMRI data from a cohort of 34 svMCI patients, comprising 18 (svMCI+D) and 16 without (svMCI-D), along normal controls (NC). The study used the fraction amplitude low-frequency fluctuations (fALFF), functional connectivity, correlation analyses, support vector machine (SVM) techniques. Results fALFF right cerebellum (CERE.R) differed among svMCI+D, svMCI-D, NC groups. Specifically, regional mean CERE. R was lower svMCI-D compared to but higher svMCI+D patients. Moreover, adjusted showed significant Montreal Cognitive Assessment (MOCA) scores orbital part superior frontal gyrus significantly correlated Hamilton Depression Scale whereas postcingulate cortex (PCC.R) MOCA Furthermore, RSFC between PCC. precuneus, as well lingual (LING.R), reduced NC. PreCUN. R, LING. decreased increased svMCI-D. Further SVM analyses achieved good performances, an area under curve (AUC) 0.82 for classifying NC; 0.96 svMCI-D; 0.92 Conclusion revealed disruptive effects impairment, both complementary spontaneous activity svMCI. these findings suggest that identified features might serve potential biomarkers distinguishing NC, thereby guiding clinical treatments such transcranial magnetic stimulation

Language: Английский

Citations

0