The role of neurotrophic factors and navigation molecules in the processes of brain development and the formation of predisposition to mental illness DOI
K. D. Bozov, A. L. Primak, О. А. Аверина

et al.

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Journal Year: 2024, Volume and Issue: 12, P. 1399 - 1415

Published: Nov. 30, 2024

Neurotrophic factors and guidance molecules are key regulators of the processes brain formation, growth maturation. During early stages embryogenesis, they stimulate proliferation differentiation neural progenitors, direct their migration, promote establishment maintenance interneuronal connections. Timely expression correct functioning multiple molecules, primarily neurotrophic factors, receptorsprovide high coordination these processes. And this makes it possible to form as an integral structure lay basis for its cognitive mental activity during a short period prenatal development. On contrary, aberrant or stoichiometry such spatial temporal impairment expression, can disrupt formation distinct structures adequate interaction redisposition number psychiatric neurological disorders schizophrenia, bipolar disorder, autism, obsessive-compulsive attention deficit hyperactivity epilepsy others. This is confirmed by clinical observations, animal studies in vitro models. Despite obvious contribution ontogenesis onto development psycho-cognitive features personality predisposition diseases, very little paid study ofbrain involved within context. Apparently, difficult identify morphogenetic signaling cascades due complexity polygenic nature disorders. All restricts our understanding etiology pathogenesis does not allow timely diagnosis prevention. The aim review summarize known facts about role disorders, emphasize need more research area molecular psychiatry.

Language: Английский

A cross-tissue transcriptome-wide association study identifies new key genes in ischemic stroke DOI

Zhiwei Song,

Yupeng Han,

Wangyu Li

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149207 - 149207

Published: Jan. 1, 2025

Language: Английский

Citations

0
C57BL/6-derived mice and the Cdh23 allele – Background matters DOI Creative Commons
Sherylanne Newton, Carlos Aguilar, Michael R. Bowl

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109278 - 109278

Published: April 1, 2025

Language: Английский

Citations

0
Associations of inflammation related prenatal adversities with neurodevelopment of offspring in one year: a longitudinal prospective birth cohort study DOI Creative Commons
Ming Gan,

Xianxian Zhu,

Weiting Wang

et al.

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Oct. 2, 2024

Language: Английский

Citations

0
Cannabis use in youth is associated with chronic inflammation DOI Creative Commons
Emmet Power, David Mongan, Colm Healy

et al.

Psychological Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 11

Published: Dec. 9, 2024

Abstract Background Markers of inflammation and cannabis exposure are associated with an increased risk mental disorders. In the current study, we investigated associations between use biomarkers inflammation. Methods Utilizing a sample 914 participants from Avon Longitudinal Study Parents Children, whether interleukin-6 (IL-6), tumor necrosis factor α (TNF ), C-reactive protein (CRP), soluble urokinase plasminogen activator receptor (suPAR) measured at age 24 were past year daily use, less frequent no use. We adjusted for number covariates including sociodemographic measures, body mass index, childhood trauma, tobacco smoking. found evidence strong association or near suPAR. Results did not find any IL-6, TNF CRP, Conclusions Our finding that is strongly suPAR, biomarker systemic chronic implicated in neurodevelopmental neurodegenerative processes novel. These findings may provide valuable insights into biological mechanisms by which affects brain impacts serious

Language: Английский

Citations

0
The role of neurotrophic factors and navigation molecules in the processes of brain development and the formation of predisposition to mental illness DOI
K. D. Bozov, A. L. Primak, О. А. Аверина

et al.

Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery), Journal Year: 2024, Volume and Issue: 12, P. 1399 - 1415

Published: Nov. 30, 2024

Neurotrophic factors and guidance molecules are key regulators of the processes brain formation, growth maturation. During early stages embryogenesis, they stimulate proliferation differentiation neural progenitors, direct their migration, promote establishment maintenance interneuronal connections. Timely expression correct functioning multiple molecules, primarily neurotrophic factors, receptorsprovide high coordination these processes. And this makes it possible to form as an integral structure lay basis for its cognitive mental activity during a short period prenatal development. On contrary, aberrant or stoichiometry such spatial temporal impairment expression, can disrupt formation distinct structures adequate interaction redisposition number psychiatric neurological disorders schizophrenia, bipolar disorder, autism, obsessive-compulsive attention deficit hyperactivity epilepsy others. This is confirmed by clinical observations, animal studies in vitro models. Despite obvious contribution ontogenesis onto development psycho-cognitive features personality predisposition diseases, very little paid study ofbrain involved within context. Apparently, difficult identify morphogenetic signaling cascades due complexity polygenic nature disorders. All restricts our understanding etiology pathogenesis does not allow timely diagnosis prevention. The aim review summarize known facts about role disorders, emphasize need more research area molecular psychiatry.

Language: Английский

Citations

0