Immediate and long-term efficacy of transcranial direct current stimulation (tCDS) in obsessive-compulsive disorder, posttraumatic stress disorder and anxiety disorders: a systematic review and meta-analysis
Luxin Xie,
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Peina Hu,
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Zhenglong Guo
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et al.
Translational Psychiatry,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 25, 2024
Currently,
there
is
still
debate
over
the
effectiveness
of
transcranial
direct
current
stimulation
(tDCS)
in
treating
obsessive-compulsive
disorder
(OCD),
posttraumatic
stress
(PTSD)
and
anxiety
disorders
(ADs).
To
investigate
immediate
long-term
tDCS
these
diseases,
we
conducted
a
systematic
review
quantitative
analysis
existing
literature
on
treatment
OCD,
PTSD,
ADs
with
tDCS.
Following
PRISMA
guidelines,
searched
seven
electronic
databases
systematically
retrieved
articles
published
from
May
2012
to
June
2024
that
compared
effects
active
sham
disorders.
We
included
primary
outcome
measures
such
as
change
scores
disorder-specific
general
symptoms
before
after
treatment,
well
secondary
outcomes
changes
at
follow-up.
also
assessed
impact
depressive
symptoms.
Fifteen
papers
met
eligibility
criteria.
Overall,
results
meta-analysis
indicated
had
high
effect
improving
specific
(SMD
=
−0.73,
95%
CI:
−1.09
−0.37)
−0.75;
−1.23
−0.26)
PTSD
ADs,
lasting
up
1
month
showing
moderate
size.
Furthermore,
demonstrated
significant
alleviation
diseases.
This
study
concludes
can
serve
non-invasive
brain
technology
for
disorders,
therapeutic
be
maintained
period
time.
Language: Английский
The Effectiveness of Transcranial Direct Current Stimulation (tDCS) on Severity of Obsessive-Compulsive Symptoms, Executive Functions and Rumination in People with Obsessive-Compulsive Symptoms: A Randomized Clinical Trial
Mohammad Jahanseir,
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Esmaeil Mousavi Asl,
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Amirali Moghadam Sadegh
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et al.
Jundishapur Journal of Chronic Disease Care,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: Jan. 25, 2025
Background:
Medical
and
cognitive
treatments
for
people
with
obsessive-compulsive
symptoms
have
limitations.
Concerns
about
arise
from
evidence
indicating
that
disorder
(OCD)
can
severe
psychological
consequences.
Objectives:
This
study
aimed
to
investigate
the
effectiveness
of
transcranial
direct
current
stimulation
(tDCS)
on
severity
symptoms,
executive
functions,
rumination
in
individuals
symptoms.
Methods:
research
was
a
randomized
clinical
trial
pre-and
post-test
design
involving
two
groups.
The
statistical
population
included
all
who
referred
Golestan
Hospital
Psychiatry
Clinic
Jundishapur
University
Sciences
Counseling
Center
Ahvaz
during
2022
-
2023.
Thirty
met
inclusion
exclusion
criteria
were
randomly
assigned
In
this
controlled
double-blind
study,
30
participants
(based
Maudsley
Questionnaire
cut-off
point
11)
receive
10
sessions
(one
session
per
day)
either
active
tDCS
(2
mA)
or
sham
treatment.
Of
these,
15
received
tDCS,
At
beginning
after
intervention,
subjects
assessed
using
Obsessional-Compulsive
(MOCI),
Executive
Functions
Questionnaire,
Yale-Brown
Obsessive
Compulsive
Scale
(Y-BOCS),
Mistake
Rumination
Scale.
Data
analysis
descriptive
statistics
covariance,
performed
SPSS-23
software.
Results:
pre-test,
mean
scores
MOCI,
Y-BOCS,
mistake
rumination,
functions
group
22.40
±
2.09,
22.33
7.72,
20.93
4.16,
86.40
14.38,
respectively,
compared
21.53
1.80,
20.33
6.89,
19.13
5.34,
83.06
16.61
treatment
group.
post-test,
14.46
3.06,
14.40
2.99,
11.46
2.13,
102.86
8.40,
21.66
1.54,
18.13
6.99,
18.26
4.89,
86.93
15.54
Results
showed
exhibited
significantly
greater
reduction
significant
improvement
(P
<
0.05).
Conclusions:
appears
effect
reducing
improving
Longer
durations
higher
number
may
be
necessary
achieve
clinically
responses.
Additionally,
determining
optimal
electrode
placement
OCD
remains
critical
challenging
issue.
Language: Английский
Efficacy and Safety of Transcranial Direct Current Stimulation (tDCS) in Patients with Obsessive-Compulsive Disorder (OCD): A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Reza Moshfeghinia,
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Amirhossein Najibi,
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Fahime Golabi
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et al.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106171 - 106171
Published: April 1, 2025
Language: Английский
Local effective connectivity changes after transcranial direct current stimulation in obsessive-compulsive disorder patients
Hanyang Ruan,
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Daniela Rodriguez Manrique,
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Chelsea Winkelmann
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et al.
Journal of Affective Disorders,
Journal Year:
2025,
Volume and Issue:
374, P. 116 - 127
Published: Jan. 11, 2025
This
study
investigates
the
effects
of
transcranial
direct
current
stimulation
(tDCS)
on
brain
network
connectivity
in
individuals
with
obsessive-compulsive
disorder
(OCD).
In
a
randomized,
double-blind,
sham-controlled
experimental
design
anodal
tDCS
(vs.
sham)
was
applied
total
43
right-handed
patients
OCD,
targeting
right
pre-supplementary
motor
area
(pre-SMA).
Cathodal
reference
electrode
put
left
pre-SMA.
The
set
as
2
mA,
duration
either
30
s
(sham)
or
1200
s.
Concurrent
resting-state
functional
MRI
data
were
collected
following
(or
stimulation.
We
employed
regression
dynamic
causal
modelling
(rDCM)
to
extract
whole
effective
(EC)
matrices
subsequently
analyzing
these
through
graph
theory
approaches
examine
changes
activity
across
different
scales.
found
that
compared
sham
caused
significant
local
connectivity.
Increased
recruitment
level
detectable
sensorimotor
(SMN),
indicating
enhanced
intra-network
after
active
tDCS.
Clustering
coefficient
and
efficiency
also
be
increased
same
area.
No
regard
global
Current
findings
indicate
single-session
can
effectively
alter
connectivities
within
SMN
OCD
patients.
Given
relevance
connected
regions
for
pathophysiology
we
believe
areas
might
constitute
an
intervention
normalize
altered
OCD.
used
single
session,
which
may
not
reflect
long-term
effects.
Language: Английский
Transcranial direct current stimulation for obsessive compulsive disorder: A systematic review and CONSORT evaluation
Journal of the International Neuropsychological Society,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Nov. 19, 2024
This
systematic
review
was
prospectively
registered
with
PROSPERO
(CRD42023426005)
and
the
data
collected
in
accordance
Preferred
Reporting
Items
for
Systematic
reviews
Meta-Analyses
(PRISMA)
guidelines.
The
quality
of
reporting
included
studies
evaluated
CONSORT
statement.
Language: Английский