Unravelling the Neuroprotective Effects of a Novel Formulation Based on Plant Extracts, Mg, and Vitamin B6

Nutraceuticals, Journal Year: 2025, Volume and Issue: 5(1), P. 5 - 5

Published: Jan. 21, 2025

The aim of the present study was to investigate phenolic composition and efficacy an innovative formulation based on Mg, Vitamin B6, water extracts from Vitex agnus-castus, Crocus sativus, Melissa officinalis, Betula pendula, pubescens developed as effective tool face neuroinflammation depression symptoms occurring in premenstrual syndrome (PMS). analyzed through colorimetric liquid chromatography methods for determining content phenols flavonoids. Additionally, scavenging/reducing properties were investigated via 2,2-diphenyl-1-picrylhydrazyl (DPPH,) 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), horseradish peroxidase assays. biocompatible limits determined allelopathy, brine shrimp lethality test, Daphnia magna cardiotoxicity assay. then assayed experimental model constituted by isolated mouse cortex specimens exposed K+ 60 mM Krebs–Ringer buffer, a toxic depolarizing stimulus able reproduce burden inflammation/oxidative stress increased serotonin (5-hydroxytryptamine, 5-HT) impoverishment different neurological psychiatric conditions, including depression. results phytochemical analysis showed that is rich benzoic acids, namely gentisic acid (155.31 µg/mL) phenylethanoid compounds, hydroxytyrosol (39.79 support antioxidant effects measured DPPH (IC50: 1.48 mg/mL), ABTS 0.42 2.02 mg/mL) ecotoxicological models indicated non-toxic, permitting identification concentration (1000 be used buffer. In this model, gene expression cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), estrogen receptor-1 (ESR1), prolactin receptor (PRLR), brain-derived neurotrophic factor (BDNF), transporter (SERT) real-time PCR. cortex, formula reduced COX-2, IL-6, SERT, ESR1, PRLR BDNF IL-10 expression. Overall, corroborated use contrast inflammation, oxidative stress, neurotransmitter impairment associated with PMS.

Language: Английский

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Pain Sensitivity and Depressive Triad Mediate the Relationship Between Trauma and Stress, and Symptoms of Premenstrual Disorders

Clinical Psychology & Psychotherapy, Journal Year: 2025, Volume and Issue: 32(2)

Published: March 1, 2025

ABSTRACT The aim of this study was to test if negative cognitive triad and subjective pain sensitivity mediate the relationship between known risk factors (trauma stress) symptoms premenstrual disorders (premenstrual syndrome [PMS] dysphoric disorder [PMDD]) measured both retrospectively prospectively. divided into two stages: a cross‐sectional ( N = 228) prospective diagnosis 90) parts. Correlation mediation analyses were performed. Both variables mediated association trauma stress with (mediation through depressive full). In sample prospectively diagnosed individuals, again, PMS/PMDD partially, there full baseline level symptomatology. However, for mean during phase, only significant, partial mediator. results suggest that may play an important role in development maintenance disorders. These findings can contribute improvement PMDD PMS treatment, emphasising importance management addressing core beliefs psychotherapy

Language: Английский

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Integrative Medicine in Women

Primary Care Clinics in Office Practice, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Features of the use of combined oral contraceptives for the correction of premenstrual syndrome

Reports of Vinnytsia National Medical University, Journal Year: 2025, Volume and Issue: 29(1), P. 142 - 145

Published: March 20, 2025

Annotation. Premenstrual syndrome (PMS) is a set of cognitive, physical, and affective symptoms that occur during the luteal phase menstrual cycle disappear at beginning menstruation. Its more severe variant premenstrual dysphoric disorder (PMDD). The aim work to investigate effects combined oral contraceptives their effectiveness safety for correction PMS PMDD. A retrospective analysis scientific literature was carried out using following sources: PubMed, ReseachGate, Science Direct, Web Science, Cochrane. majority publications published in last five years (2019-2024) were selected study. Both syndromes are believed be caused by cyclical changes progesterone production. Combined (COCs) considered one treatment options PMDD, as drugs this group contain synthetic estradiol progestin, which have complex effect on hypothalamic-pituitary-ovarian system.

Language: Английский

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Menstruation and Autism: A Qualitative Systematic Review

Autism in Adulthood, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Menstruation is a biological process which can be irregular, painful, and co-occur with fatigue, social withdrawal, increased emotions. There some evidence to suggest Autistic people experience menstruation differently non-Autistic people. This systematic review (PROSPERO registration: CRD42023399674) searched four databases in February 2023. We used thematic synthesis analyse qualitative studies of experiences related for providing support also appraised the quality CASP. Our twelve (eight peer-reviewed; grey literature) sources identified differing priorities between parents, professionals, reported physical, emotional impacts menstruation. Furthermore, there were reports Autism-specific during such as sensory sensitivities, burnout anxiety, often unseen by those who supported them. people's obtaining knowledge skills ahead their first period. However, parents professionals focused on external behaviours including hygiene independence managing periods. Sources poorly described participant demographics had limited focus perspectives. conclude needs tailored meet both individuals should informed research centers

Language: Английский

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Estrogeni, infiammazione e sintomi catameniali: implicazioni per i clinici

L Endocrinologo, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

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Genistein Reduces Anxiety-like Behavior During Metestrus–Diestrus Phase Without Changing Estradiol or Progesterone Levels in Wistar Rats

Metabolites, Journal Year: 2025, Volume and Issue: 15(5), P. 311 - 311

Published: May 6, 2025

Background: Premenstrual syndrome is characterized by emotional changes, including anxiety and depression symptoms, which may be treated with anxiolytic antidepressant drugs, as well estrogen therapy. However, steroidal therapy contraindicated for patients a potential risk of developing estrogen-dependent cancers through interactions receptor α (ERα). Alternatively, genistein produces estrogenic effects in animals humans at dietary dosages that act on the nuclear membrane ERα, β (ERβ), G-protein-coupled (GPER). These receptors are likely involved symptoms observed premenstrual disorders. The objective this study was to evaluate 17β-estradiol anxiety-like behavior plasma concentrations estradiol progesterone throughout ovarian cycle Wistar rats. Methods: effect administration 0.09 mg/kg or evaluated using elevated plus maze (EPM) test, locomotor activity test (LAT), light/dark box (LDB) assessing progesterone, while considering phases. Results: Higher levels were detected metestrus–diestrus phase compared proestrus–estrus phase, associated low estradiol. Genistein, similarly 17β-estradiol, significantly reduced behaviors EPM LDB; however, but not genistein, increased concentration. No significant changes found due treatments. Conclusions: findings suggest useful development alternative therapies reduce steroid hormone concentrations, occur syndrome. Genistein could an avoid side treatments, although it still requires medical care.

Language: Английский

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The effectiveness of cognitive-behavioral hypnotherapy on dysmenorrhea, premenstrual syndrome and affective control

American Journal of Clinical Hypnosis, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: May 7, 2025

The objective of this study was to assess the effects cognitive-behavioral hypnotherapy on dysmenorrhea, premenstrual syndrome, and women's emotional management. Utilizing a quasi-experimental design with control group, research adopted pretest-posttest method. focus group comprised women reproductive age seeking counseling psychological services at Ferdowsi University Mashhad. Fifty participants were selected through purposive sampling randomly divided into two groups - experimental 25 in each. They completed Visual Analog Scale, Premenstrual Symptoms Screening Tool (PSST), Affective Control Scale (ACS) before after intervention. data analyzed using Analysis Covariance (ANCOVA) SPSS-21 software. findings revealed that significantly reduced dysmenorrhea pain, symptoms improved regulation. Therefore, therapy, which includes suggestion relaxation techniques, is recommended for enhancing quality life suffering from menstrual discomfort, as well related distress. It suggested treatment issues stemming pain symptoms.

Language: Английский

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Premenstrual Dysphoric Disorder and Severe Premenstrual Syndrome: A Lifestyle-Based Approach to Management

Published: Jan. 1, 2025

Pharmaceutical treatments are currently the primary approach to managing premenstrual dysphoric disorder (PMDD) and severe syndrome (PMS). However, limited pharmaceutical options offer variable efficacy come with potentially undesirable side effects. A deeper understanding of pathophysiology these conditions allows women’s healthcare providers consider a more holistic approach. To enhance outcomes, should be well-versed in diagnosing PMDD PMS, including knowledge nonpharmaceutical treatment options, while also offering education support help patients navigate challenging disorders. This article presents current evidence on effectiveness lifestyle-based, interventions PMS. There is focus PMDD.

Language: Английский

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Brain fingerprint and subjective mood state across the menstrual cycle

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Dec. 6, 2024

Background Brain connectome fingerprinting represents a recent and valid approach in assessing individual identifiability on the basis of subject-specific brain functional connectome. Although this methodology has been tested validated several neurological diseases, its performance, reliability reproducibility healthy individuals poorly investigated. In particular, impact changes connectivity, induced by different phases menstrual cycle (MC), remains unexplored. Furthermore, although modifications psychological condition women during MC are widely documented, possible link with connectivity Methods We conducted Clinical Connectome Fingerprint (CCF) analysis source-reconstructed magnetoencephalography signals cohort 24 across MC. Results All parameters did not differ according to phases. The peri-ovulatory mid-luteal showed less stable, more variable over time, compared early follicular phase. This difference stability alpha band significantly predicted self-esteem level ( p -value <0.01), mood <0.01) five (environmental mastery, personal growth, positive relations others, purpose life, self-acceptance) six dimensions well-being <0.01, save autonomy). Conclusion These results confirm high CCF as well independence from At same time study provides insights their role affecting women’s subjective state Finally, these share predictive power self-esteem, well-being.

Language: Английский

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