Effect of muscle strength on deep vein thrombosis: A Mendelian randomization study DOI Creative Commons
Yijia Gao, Hui Chen,

Dao-Ze Ke

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(45), P. e40138 - e40138

Published: Nov. 8, 2024

Deep vein thrombosis (DVT) is a serious condition characterized by blood clots in deep veins, posing significant public health burden. Muscle strength has been implicated as potential risk factor for DVT due to its influence on venous return. This study aims investigate the causal association between muscle and using Mendelian randomization (MR) approach, leveraging genetic variants instrumental variables (IVs). We conducted 2-sample MR analysis genome-wide (GWAS) data hand-grip DVT. IVs were selected based their associations with DVT, well linkage disequilibrium patterns. employed statistical methods including inverse-variance weighting (IVW), MR-Egger, weighted median address pleiotropy bias. Sensitivity analyses evaluate robustness of results. A total 21 14 independent identified hand grip (EWGSOP) (FNIH), respectively. IVW revealed consistent negative both definitions (EWGSOP: OR = 0.702, 95% CI: 0.511-0.964, P .029; FNIH: 0.715, 0.570-0.898, .004). No directional was detected MR-Egger MR-PRESSO either definition Intercept .516; global test .162; .569; .371).Sensitivity demonstrated stability effect estimates, little from individual IVs. The provided evidence risk, suggesting that increasing may have protective effect. These findings implications preventive strategies promotion resistance exercises muscle-strengthening activities. Further research validation these results could inform clinical guidelines interventions prevention.

Language: Английский

Effect of muscle strength on deep vein thrombosis: A Mendelian randomization study DOI Creative Commons
Yijia Gao, Hui Chen,

Dao-Ze Ke

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(45), P. e40138 - e40138

Published: Nov. 8, 2024

Deep vein thrombosis (DVT) is a serious condition characterized by blood clots in deep veins, posing significant public health burden. Muscle strength has been implicated as potential risk factor for DVT due to its influence on venous return. This study aims investigate the causal association between muscle and using Mendelian randomization (MR) approach, leveraging genetic variants instrumental variables (IVs). We conducted 2-sample MR analysis genome-wide (GWAS) data hand-grip DVT. IVs were selected based their associations with DVT, well linkage disequilibrium patterns. employed statistical methods including inverse-variance weighting (IVW), MR-Egger, weighted median address pleiotropy bias. Sensitivity analyses evaluate robustness of results. A total 21 14 independent identified hand grip (EWGSOP) (FNIH), respectively. IVW revealed consistent negative both definitions (EWGSOP: OR = 0.702, 95% CI: 0.511-0.964, P .029; FNIH: 0.715, 0.570-0.898, .004). No directional was detected MR-Egger MR-PRESSO either definition Intercept .516; global test .162; .569; .371).Sensitivity demonstrated stability effect estimates, little from individual IVs. The provided evidence risk, suggesting that increasing may have protective effect. These findings implications preventive strategies promotion resistance exercises muscle-strengthening activities. Further research validation these results could inform clinical guidelines interventions prevention.

Language: Английский

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