Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk DOI Creative Commons
Patricia Guevara-Ramí­rez, Rafael Tamayo‐Trujillo, Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 3, 2024

Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration neurons within nervous system. Even though, each pathology presents diverse etiologies develops in different brain sites, they may share cellular molecular mechanisms, such as inflammation, protein aggregation, DNA RNA defects. Heavy metal contamination is global public health concern, given that anthropogenic activities like paint manufacturing, mining, oil refining contribute substantially heavy pollution. Consequently, studies have investigated its potential etiological factors neurodegenerative diseases. This review examines impact dietary exposure metals, specifically mercury, cadmium, lead, chromium, arsenic, zinc, on development progression Evidence from range indicates these metals play significant role advancing by disrupting essential functions, induction oxidative stress impairments mitochondrial function. findings underscore need for further research elucidate toxicological mechanisms develop preventive strategies, chelation therapies environmental remediation. Addressing risks especially critical protect neurocognitive health, particularly aging populations.

Language: Английский

Psychological Mechanism of Outdoor Physical Exercise in Polluted Weather Based on Social Cognitive Theory DOI Open Access
Wentao Ma

International Journal of Healthcare Information Systems and Informatics, Journal Year: 2025, Volume and Issue: 20(1), P. 1 - 22

Published: Jan. 17, 2025

Despite improved living standards, many individuals continue to engage in outdoor physical exercise despite air pollution. This study explores the psychological mechanisms that facilitate this behavior adverse environmental conditions. Using Social Cognitive Theory as a framework, we investigate reasons choose outdoors polluted weather compared those who prefer cleaner Our research includes statistical analysis of demographic data and an examination social factors influencing habits. We distributed structured questionnaire 300 participants, receiving 290 responses, which 280 were valid. By analyzing these aim uncover drivers sustain commitment pollution challenges. The findings provide valuable insights into motivations encourage maintain their activity less-than-ideal

Language: Английский

Citations

0

Traffic pollution, reproductive health, and depressive symptoms in a healthy multiethnic sample of reproductive age women in the Ovarian Aging Study DOI

Anwesha Pan,

Martha Grace Cromeens, Marcelle I. Cedars

et al.

Menopause The Journal of The North American Menopause Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Objective This study aimed to determine whether exposure traffic-related air pollution (TRAP) is associated with depressive symptoms while also characterizing the contribution of key explanatory factors related sociodemographics and health. In addition, it explore role reproductive health as a pathway through which TRAP may relate symptoms. Methods Participants were 688 healthy reproductive-age women in Ovarian Aging Study. was derived from distance-weighted traffic counts using residential addresses. Depressive assessed by Center for Epidemiological Studies Depression scale. Explanatory interview clinic measures, including demographics (age, race/ethnicity), socioeconomic status (SES) (individual SES, neighborhood SES), general (smoking, body mass index), (menarcheal age, contraceptive use, parity, menstrual cycle characteristics). Results cross-sectional, step-wise multivariate regression analyses, greater more ( b = 0.779, P 0.015). Lower individual longer length, experiencing change (vs no change) length 's < 0.05). Examination each model step showed that variance attributable (1.2%, 0.004), (1.0%, 0.217), SES (1.4%, 0.007), (0.3%, 0.356), (2.0%, Finally, marker status, partially mediated effects on (indirect effect: 0.064, 0.020). Conclusions Findings depression, along factors, be relates depression.

Language: Английский

Citations

0

Grounding And Solutions of Ecological Sustainability, Stomatology, And Human Health Problems in Scientific-Practical-Experiments DOI Creative Commons

Gafforov Sunnatullo Amrulloyevich,

Mo’minova Dilnoza Rahimovna,

Nazarov Ulug’bek Qahramonovich

et al.

Journal of Ecohumanism, Journal Year: 2024, Volume and Issue: 3(4), P. 886 - 897

Published: Aug. 2, 2024

The results of a long-term scientific study on the negative impact chemical, physical, biological, physical factors organism workers and environmental environment industrial enterprises Republic Uzbekistan neighboring state regions cause workplaces, ecogigienic in ecological control regime production process were comprehensively evaluated. authors say that to eliminate influence system human body, it is necessary not only conduct activities area one or territory but also simultaneously fight existing states, non-governmental societies people land sphere, promote concepts education widely.

Language: Английский

Citations

1

Air Pollution Effects on Mental Health Relationships: Scoping Review on Historically Used Methodologies to Analyze Adult Populations DOI Open Access
Kristina Leontjevaite, Aoife Donnelly, Tadhg MacIntyre

et al.

Air, Journal Year: 2024, Volume and Issue: 2(3), P. 258 - 291

Published: Aug. 12, 2024

Air pollution’s effects on physical health, especially cardiovascular and respiratory, are well known. Exposure to air pollution may damage every organ cell in the human body. New evidence is emerging showing that adversely affects mental health. Current research suggests high levels have long-term health effects, such as reduced capacity increased cognitive decline, leading stress, anxiety, depression. Objectives: This scoping review aims provide a comprehensive overview of methods used epidemiological literature ascertain existence links between outdoor particulate matter (PM) multiple adverse (MH) (depression, and/or stress). A better understanding practical methodologies could lead improved quality (AQ) management enhanced well-being strategies. Methods: paper undertakes review. PubMed EMBASE databases from 2010 2024 were searched for English-language cohort observational studies stating analyzing link (ultrafine (UFT) (<0.1 μm), fine (<2.5 course (<10 μm)) outcomes stress) adults (>18 years), excluding vulnerable populations (i.e., elderly, children, pregnant women). The study focuses urban, suburban areas, rural areas. Results: From an initial search 3889 records, 29 met inclusion criteria included These spanned various countries employed robust quantitative assess AQ MH. All investigated impact PM with some (n = 19/65.52%) also examining nitrogen oxides (NOx), dioxide (NO2), sulfur (SO2), ozone (O3), carbon monoxide (CO). Depression was most frequently studied outcome 10/34.48%), followed by anxiety depression 6/20.69%), depression, stress 4/13.79%, each). Depression, together examined single 1/3.45%). Standardized questionnaires involving psychological scales Patient Health Questionnaire (PHQ) 7/24.14%) Center Epidemiological Studies-Depression (CES-D) 3/10.34%) Generalized Anxiety Disorder (GAD) 2/6.90%) commonly MH tools. 27 out found significant negative demonstrating solid consensus literature. Two did not find correlation. results consistently indicated higher associated symptoms stress. Conclusion: Of identified studies, suitable per criteria. show preferred assessing relevant providing detailed account each method’s strengths limitations studies. conducted assist future relieve decision-making process researchers aiming correlation While strict thus resulted few gap concerning general adult population, focused populations. Further exploration relationship needed, reporting these limited.

Language: Английский

Citations

1

Impact of climate change on women mental health in rural hinterland of Pakistan DOI Creative Commons
Umar Daraz, Younas Khan, Rula Odeh Alsawalqa

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background Climate change significantly impacts global well-being, with rural and agricultural communities, particularly women, bearing a disproportionate burden. In Pakistan’s Malakand Division, women face increased mental health challenges due to environmental stressors such as temperature rise, extreme weather, degradation. These are expected exacerbate issues like stress, anxiety, depression. Understanding their effects on women’s is crucial for developing effective intervention strategies. Methodology This study employs quantitative methodologies assess the impact of climate in focusing Dir Upper, Lower, Shangla districts. A cross-sectional design was used, sample size 600 selected through multistage cluster sampling geographic representation. Data were collected using structured questionnaires addressing community dynamics. analyzed multiple regression, structural equation modeling (SEM), ANOVA, logistic regression. Results The results revealed that factors—temperature increase (β = 0.42, p &lt; 0.01), weather events 0.36, precipitation changes 0.31, 0.05), degradation 0.28, 0.05)—significantly impacted health. High levels stress (72%), anxiety (68%), depression (56%) reported. Social support -0.45, cohesion -0.37, access resources -0.39, cultural norms -0.33, 0.05) key factors mitigating stress. Gender disparities evident, showing higher compared men similar conditions. Conclusion concludes exacerbates women. It highlights need gender-sensitive, community-based interventions address both adaptation Strengthening resilience, improving resources, investing healthcare education vital enhancing well-being change.

Language: Английский

Citations

1

Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk DOI Creative Commons
Patricia Guevara-Ramí­rez, Rafael Tamayo‐Trujillo, Santiago Cadena-Ullauri

et al.

Food and Agricultural Immunology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Dec. 3, 2024

Neurodegenerative diseases (NDDs) affect millions of lives worldwide. They constitute a group neurological disorders with shared common features, including impaired cognition, behavior, memory, and motor functions. These conditions arise due to the gradual degeneration neurons within nervous system. Even though, each pathology presents diverse etiologies develops in different brain sites, they may share cellular molecular mechanisms, such as inflammation, protein aggregation, DNA RNA defects. Heavy metal contamination is global public health concern, given that anthropogenic activities like paint manufacturing, mining, oil refining contribute substantially heavy pollution. Consequently, studies have investigated its potential etiological factors neurodegenerative diseases. This review examines impact dietary exposure metals, specifically mercury, cadmium, lead, chromium, arsenic, zinc, on development progression Evidence from range indicates these metals play significant role advancing by disrupting essential functions, induction oxidative stress impairments mitochondrial function. findings underscore need for further research elucidate toxicological mechanisms develop preventive strategies, chelation therapies environmental remediation. Addressing risks especially critical protect neurocognitive health, particularly aging populations.

Language: Английский

Citations

0