Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study DOI Creative Commons
Wenxi Sun, Ping Sun,

Sijia Tang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 23, 2024

In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying association between and disorders remain unclear. We conducted a two-sample Mendelian randomization (MR) study to assess causal relationship frailty, as measured by index (FI), ten common The datasets involved European ancestry individuals included measurements of FI (N = 175,226), schizophrenia (SCZ; N 320,404), major depressive disorder (MDD; 143,265), bipolar 337,199), insomnia 462,341), obsessive–compulsive 33,925), anxiety 463,010), autism spectrum 46,351), anorexia nervosa 14,477), opioid-related behavioral 215,650), due use other stimulants including caffeine 215,570). Two-sample MR analyses were performed using inverse variance weighting followed various sensitivity validation analyses. Genetically predicted SCZ (odds ratio [OR] 1.019, 95% confidence interval [CI] 1.005–1.033) MDD (OR 1.211, CI 1.092–1.343) had significant effects on FI. reverse analysis, we discovered that was significantly causally affected 1.290, 1.133–1.469). No links identified eight Multivariable MR, estimated effect is comparable univariate IVW estimate 1.298; CI, 1.175 1.435), while fails be compared estimate. results confirmed stabilization. Our found evidence SCZ, MDD, explored mechanisms.

Language: Английский

Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study DOI Creative Commons
Yong Zhou, Jubao Duan,

Jiayi Zhu

et al.

BJPsych Open, Journal Year: 2025, Volume and Issue: 11(2)

Published: Feb. 3, 2025

An increasing number of observational studies have reported associations between frailty and mental disorders, but the causality remains ambiguous. To assess bidirectional causal relationship nine disorders. We conducted a two-sample Mendelian randomisation on genome-wide association study summary data, to investigate Causal effects were primarily estimated using inverse variance weighted method. Several secondary analyses applied verify results. Cochran's Q-test Egger intercept evaluate heterogeneity pleiotropy. Genetically determined was significantly associated with increased risk major depressive disorder (MDD) (odds ratio 1.86, 95% CI 1.36-2.53, P = 8.1 × 10-5), anxiety 2.76, 1.56-4.90, 5.0 10-4), post-traumatic stress (PTSD) 2.56, 1.69-3.87, 9.9 10-6), neuroticism (β 0.25, 0.11-0.38, 3.3 10-4) insomnia 0.50, 0.25-0.75, 1.1 10-4). Conversely, genetic liability MDD, neuroticism, suicide attempt (MDD: β 0.071, 0.033-0.110, 2.8 10-4; neuroticism: 0.269, 0.173-0.365, 3.4 10-8; insomnia: 0.160, 0.141-0.179, 3.2 10-61; attempt: 0.056, 0.029-0.084, 10-5). There suggestive detrimental an subjective well-being frailty. Our findings show neuroticism. Additionally, higher levels are PTSD, attempts correlated Understanding these is crucial for effective management improvement

Language: Английский

Citations

2
Dual trajectories of social participation and frailty in Chinese older adults: a longitudinal study based on CLHLS from 2008 to 2018 DOI Creative Commons

Yiyun Bi,

Jing Hu, Yilei Ma

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 4, 2024

This study aimed to identify the dual trajectories of social participation (SP) and frailty index (FI) among Chinese older adults, investigate common influential factors both trajectories.

Language: Английский

Citations

1
Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study DOI Creative Commons

Zuying Liu,

Jiaming Fan,

Huilian Bu

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Sept. 11, 2024

Language: Английский

Citations

1
Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study DOI Creative Commons
Wenxi Sun, Ping Sun,

Sijia Tang

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 23, 2024

In observational studies, frailty has been strongly associated with mental disorders. However, the mechanisms underlying association between and disorders remain unclear. We conducted a two-sample Mendelian randomization (MR) study to assess causal relationship frailty, as measured by index (FI), ten common The datasets involved European ancestry individuals included measurements of FI (N = 175,226), schizophrenia (SCZ; N 320,404), major depressive disorder (MDD; 143,265), bipolar 337,199), insomnia 462,341), obsessive–compulsive 33,925), anxiety 463,010), autism spectrum 46,351), anorexia nervosa 14,477), opioid-related behavioral 215,650), due use other stimulants including caffeine 215,570). Two-sample MR analyses were performed using inverse variance weighting followed various sensitivity validation analyses. Genetically predicted SCZ (odds ratio [OR] 1.019, 95% confidence interval [CI] 1.005–1.033) MDD (OR 1.211, CI 1.092–1.343) had significant effects on FI. reverse analysis, we discovered that was significantly causally affected 1.290, 1.133–1.469). No links identified eight Multivariable MR, estimated effect is comparable univariate IVW estimate 1.298; CI, 1.175 1.435), while fails be compared estimate. results confirmed stabilization. Our found evidence SCZ, MDD, explored mechanisms.

Language: Английский

Citations

0