No reliable gray matter alterations in idiopathic dystonia

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Background The structural brain abnormalities associated with idiopathic dystonia (ID) remain inadequately understood. Previous voxel-based morphometry (VBM) studies examining whole-brain gray matter (GM) volume alterations in patients ID have reported inconsistent and occasionally contradictory findings. Methods We performed a coordinate-based meta-analysis (CBMA) using the latest seed-based d mapping permutation of subject images (SDM-PSI) technique to identify consistent GM at level. Additionally, meta-regression analyses were conducted explore potential moderating effects age, gender, disease duration on volume. Results CBMA incorporated 27 VBM studies, comprising 32 datasets total 840 834 healthy controls. Our analysis did not or reliable ID. robustness these findings was confirmed through jackknife sensitivity analysis. Meta-regression revealed that significantly influenced right insula. Conclusion Based best practice guidelines for CBMA, we utilized most recent SDM-PSI algorithm perform new included larger group individuals However, contrast previous CBMAs, observe any suggest assessed by as an imaging marker may be reliable. This could attributed being functional disorder, inconsistency demographic clinical variations, differences protocols methods, small sample sizes. It is imperative control characteristics, employ standardized methodologies, enhance sizes future research.

Language: Английский

Brain Structural Alterations Underlying Mood-Related Deficits in Schizophrenia

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 736 - 736

Published: March 18, 2025

Background/Objectives: Schizophrenia (SZ) is a complex psychiatric disorder characterized by neurodegenerative processes, but the structural brain alterations associated with its progression remain poorly understood. This study investigated changes in SZ, particularly fronto-temporal and limbic regions, explored their relationship symptom severity, focus on mood- emotion-related symptoms. Methods: We analyzed MRI data from 74 SZ patients 91 healthy controls (HCs) using voxel-based morphometry (VBM) to compare whole-brain grey matter volumes (GMVs). The analysis focused correlations between GMV severity were assessed Positive Negative Syndrome Scale (PANSS) Generalized Psychopathology (GP) scale. Results: exhibited significant reductions including dorsolateral prefrontal cortex (dlPFC) temporal pole, compared HCs. Notably, positive association was found right inferior gyrus (ITG) of generalized psychopathology, as well anxiety, depression, mannerisms, unusual thought content. Further post hoc identified specific cluster mood-related symptoms contributing GP scale, which correlated ITG. Conclusions: Our findings provide new evidence suggesting progressive pattern. role ITG requires further exploration, it could offer insights into pathophysiology aid distinguishing other disorders.

Language: Английский

Gray matter structural and functional brain abnormalities in Parkinson’s disease: a meta-analysis of VBM and ALFF data

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 19, 2025

Language: Английский