The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 24, 2025

The American Heart Association (AHA) proposed the concept of cardiovascular–kidney–metabolic (CKM) syndrome, underscoring interconnectedness cardiovascular, renal, and metabolic diseases. stress hyperglycemia ratio (SHR) represents an innovative indicator that quantifies blood glucose fluctuations in patients experiencing acute or subacute stress, correlating with detrimental clinical effects. Nevertheless, prognostic significance SHR within individuals diagnosed CKM syndrome stages 0 to 3, particularly respect all-cause cardiovascular disease (CVD) mortality risks, has not been fully understood yet. current study analyzed data from 9647 participants covering based on NHANES (National Health Nutrition Examination Survey) collected 2007 2018. In this study, primary exposure variable was SHR, computed as fasting plasma divided by (1.59 * HbA1c − 2.59). main endpoints were well CVD mortality, death registration sourced through December 31, 2019. CHARLS database (China Retirement Longitudinal Study) utilized validation enhance reliability findings. This included participants, who followed for a median duration 6.80 years. During period, 630 cases 135 CVD-related deaths total recorded. After full adjustment covariates, our results displayed robust positive association (Hazard [HR] = 1.09, 95% Confidence interval [CI] 1.04–1.13). However, exhibited no significant relationship (HR 1.00, CI 0.91–1.11). mediation analysis suggested between risk is partially mediated RDW, albumin, RAR. Specifically, mediating effects 17.0% (95% 46.7%, 8.7%), 10.1% 23.9%, 4.7%), 23.3% 49.0%, 13.0%), respectively. Additionally, analyses indicated correlation among across 0–3 during follow-up period 2011 2020. An increased value positively associated elevated likelihood 0–3, yet it shows mortality. important tool predicting long-term adverse outcomes population. Cardiovascular–kidney–metabolic emphasizes kidney, novel marker reflecting stress-induced fluctuations, but its (stages 0–3) remains uncertain. explores Our findings indicate significantly 1.04–1.13), CI: Mediation Validation using supports these These suggest could serve biomarker patients, offering potential utility stratification management.

Language: Английский

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Correlation between estimated glucose disposal rate and diabetic depression: a population-based study

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: March 25, 2025

Background Emerging evidence has identified a correlation between depression and insulin resistance (IR). This study aims to explore the estimated glucose disposal rate (eGDR)—a noninvasive practical measure of IR—and in patients with diabetes mellitus (DM). Methods In this cross-sectional study, data from 3,080 adults aged 18 years old or older DM obtained NHANES 1999–2018 were analyzed. The eGDR examined through multivariate logistic regression, subgroup analyses, restricted cubic spline (RCS) analysis, interaction tests. Additionally, mediation analysis was conducted assess whether leukocytes neutrophils could mediate effects on depression. Results Multivariate regression RCS analyses demonstrate that negative linearly correlated diabetic (OR= 0.89; 95% CI: 0.84, 0.95). Patients Q3 Q4 exhibited reduced risk 28% 54%, respectively, depression, compared those Q1. Subgroup stratified by variables such as gender, BMI, age, education level, medical comorbidities, consistently showed correlation. Mediation further indicates accounted for 4.0% 3.6% respectively. Conclusions results demonstrated statistically significant inverse linear prevalence DM, acting mediating factors

Language: Английский

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Inflammatory burden index is correlated with increased depression: a population-based study

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 31, 2025

Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating inflammation. This study aims to explore the correlation between IBI and depression in general population. cross-sectional was designed analyze data from National Health Nutrition Examination Survey (NHANES) during period 1999 2018. formulated C-reactive protein×neutrophils/lymphocytes. prevalence of explored through multivariate logistic regression analyses, well subgroup, interaction, restricted cubic spline (RCS) sensitivity analyses. A total 14,557 subjects were included this study, whom, 1231 (8.5%) had depression. According RCS significantly linearly positive observed [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, P 0.007]. Subjects third tertile exhibited higher depression, 40.0% affected, compared those first (P < 0.001). consistently across all subgroups stratified analysis (all interaction > 0.05). After analyses excluding participants upper lower 2.5% IBI, remained stable (OR 1.08; 95%CI, 1.15, These findings indicate American adults. Further large-scale prospective studies are still needed role

Language: Английский

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Red blood cell distribution width-to-albumin ratio and its association with age-related macular degeneration: a population-based cross-sectional study

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Background Age-related macular degeneration (AMD) is a leading cause of central vision impairment in middle-aged and older individuals. There substantial evidence that AMD associated with inflammation. The study aimed to investigate the association between inflammatory marker, red blood cell distribution width/albumin ratio (RAR), AMD. Methods Our included 5,370 participants aged 40 years older, using NHANES data from 2005 2008. Multivariable logistic regression analysis was conducted examine relationship RAR study. Smooth curves piecewise linear model were used determine whether correlation or non-linear. Additionally, subgroup interaction testing performed. Results We found positive AMD, even after adjusting for covariates. Each unit increase corresponded 30% odds prevalence (OR = 1.3; 95% CI, 1.0–1.6). 1.7 times greater highest quintile (Q5) group than lowest (Q1) 1.7; 1.2–2.5). Higher values, compared lower significantly increased ( p trend &lt; 0.05). Subgroup analyses tests confirmed stability findings. Conclusion This there United States adults. Further research necessary clarify specific physiological mechanisms underlying

Language: Английский

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