Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2021, Volume and Issue: 107(5), P. 1484 - 1502

Published: Dec. 11, 2021

Abstract Purpose Vitamin D deficiency/insufficiency may increase the susceptibility to coronavirus disease 2019 (COVID-19). We aimed determine association between vitamin and COVID-19, its severity, mortality, role of in treatment. Methods searched CINAHL, Cochrane library, EMBASE, PubMED, Scopus, Web Science up May 30, 2021, for observational studies on severe disease, death among adults, and, randomized controlled trials (RCTs) comparing treatment against standard care or placebo, improving severity mortality adults with COVID-19. Risk bias was assessed using Newcastle-Ottawa scale AUB-KQ1 tool RCTs. Study-level data were analyzed RevMan 5.3 R (v4.1.0). Heterogeneity determined by I2 sources explored through prespecified sensitivity analyses, subgroup meta-regressions. Results Of 1877 search results, 76 satisfying eligibility criteria included. Seventy-two included meta-analysis (n = 1 976 099). increased odds developing COVID-19 (odds ratio [OR] 1.46; 95% CI, 1.28-1.65; P < 0.0001; 92%), (OR 1.90; 1.52-2.38; 81%), 2.07; 1.28-3.35; 0.003; 73%). The 25-hydroxy concentrations lower individuals compared controls (mean difference [MD] -3.85 ng/mL; -5.44 -2.26; ≤ 0.0001), patients nonsevere (MD -4.84 -7.32 -2.35; 0.0001) nonsurvivors survivors -4.80 -7.89 -1.71; 0.002). insignificant when high risk reporting unadjusted effect estimates excluded. heterogeneity across all analyses. Discrepancies timing testing, definitions partly explained heterogeneity. Four RCTs widely heterogeneous precluding meta-analysis. Conclusion Multiple involving nearly 2 million suggest increases although a Association less robust. precluded their

Language: Английский

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Vitamin D supplementation and clinical outcomes in COVID-19: a systematic review and meta-analysis

Journal of Endocrinological Investigation, Journal Year: 2021, Volume and Issue: 45(1), P. 53 - 68

Published: June 24, 2021

Language: Английский

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Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(7), P. e0268396 - e0268396

Published: July 6, 2022

To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency supplementation of vitamin D, we conducted a systematic review up April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT 27 cohort-studies: 205565 patients with information 25OHD status 2022 taking D total 1197 admitted ICU or who needed invasive mechanical ventilation intubation hospital stay, more than 910 deaths. Primary outcomes were severity mortality main aim was evaluate association supplementation. Random effects models showed that associated significant lower both severe disease (SRR 0.38, 95% CI 0.20-0.72, 6 studies) 0.35, 0.17-0.70, 8 studies). There no statistically dose differences between studies: summary regular doses remain significant, suggesting higher are not necessary. For supplementation, greater reduction emerged older individuals latitudes. Regarding quality assessed using New Castle-Ottawa scale, analysis revealed most cases low, medium high studies. found associations Covid-19, encompassing risks worsening mortality, especially seasons characterized by patients. Dedicated randomized clinical studies encouraged confirm these results.

Language: Английский

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Dysregulation of immune response in PCOS organ system

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 5, 2023

Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder affecting women, which can lead to infertility. Infertility, obesity, hirsutism, acne, and irregular menstruation are just a few of issues that PCOS be linked to. has complicated pathophysiology range clinical symptoms. Chronic low-grade inflammation one features PCOS. The inflammatory environment involves immune metabolic disturbances. Numerous organ systems across body, in addition female system, have been affected by pathogenic role immunological dysregulation recent years. Insulin resistance hyperandrogenism associated with cell dysfunction cytokine imbalance. More importantly, obesity also involved PCOS, leading an women Hormone, interactions contribute pathogenesis Hormone imbalance may development autoimmune diseases. aim this review summarize pathophysiological various patients provide new ideas for systemic treatment future.

Language: Английский

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COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2021, Volume and Issue: 13(10), P. 3596 - 3596

Published: Oct. 14, 2021

Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 caused by the or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on topic.

Language: Английский

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Vitamin D: Bolus Is Bogus—A Narrative Review

JBMR Plus, Journal Year: 2021, Volume and Issue: 5(12)

Published: Oct. 14, 2021

In this review we summarize the impact of bolus versus daily dosing vitamin D on 25(OH)D and 1,25(OH)

Language: Английский

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Does Evidence Exist to Blunt Inflammatory Response by Nutraceutical Supplementation during COVID-19 Pandemic? An Overview of Systematic Reviews of Vitamin D, Vitamin C, Melatonin, and Zinc

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1261 - 1261

Published: April 12, 2021

More than one year has passed since the first cases of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS)-CoV-2 were reported in Wuhan (China), rapidly evolving into a global pandemic. This infectious become major public health challenge world. Unfortunately, to date, no specific antivirals have been proven be effective against COVID-19, and although few vaccines are available, mortality rate is not decreasing but still increasing. One therapeutic strategy focused on infection prevention control measures. In this regard, use nutraceutical supports may play role some aspect infection, particularly inflammatory state immune system function patients, thus representing worst outcomes For reason, we performed an overview including meta-analyses systematic reviews assess association among melatonin, vitamin C, D, zinc supplementation markers using three databases, namely, MEDLINE, PubMed Central Cochrane Library Systematic Reviews. According evidence intake 50,000 IU/month D showed efficacy CRP. An amount 1 2 g per day C demonstrated both CRP endothelial function, dosage melatonin ranging from 5 25 mg /day good CRP, TNF IL6. A dose 50 mg/day elemental positive results Based data review, could consider whether it possible supplement current limited preventive measures through targeted large-scale administration.

Language: Английский

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COVID-19-Related Mortality Risk in People With Severe Mental Illness: A Systematic and Critical Review

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 13, 2022

Background: Increasing clinical evidence suggests that people with severe mental illness (SMI), including schizophrenia spectrum disorders, bipolar disorder (BD), and major depressive (MDD), are at higher risk of dying from COVID-19. Several systematic reviews examining the association between psychiatric disorders COVID-19-related mortality have recently been published. Although these conducted thoroughly, certain methodological limitations may hinder accuracy their research findings. Methods: A literature search, using PubMed, Embase, Web Science, Scopus databases (from inception to July 23, 2021), was for observational studies assessing death associated COVID-19 infection in adult patients pre-existing BD, or MDD. Methodological quality included assessed Newcastle-Ottawa Scale (NOS). Results: Of 1,446 records screened, 13 articles investigating rates SMI were this review. Quality assessment scores ranged moderate high. Most results seem indicate SMI, particularly significantly mortality, as compared without SMI. However, extent variation large because a low level precision estimated outcome(s) studies. on MDD BD did not include specific information mood state disease severity patients. Due lack data, it remains unknown what increased mortality. variety factors likely contribute These male sex, older age, somatic comorbidities (particularly cardiovascular diseases), well disease-specific characteristics. Conclusion: hamper estimates main categories SMIs. Nevertheless, is excess Policy makers therefore must consider vulnerable individuals high-risk group should be given particular attention. This means targeted interventions maximize vaccination uptake among required address burden already disadvantaged group.

Language: Английский

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Therapeutic high-dose vitamin D for vitamin D-deficient severe COVID-19 disease: randomized, double-blind, placebo-controlled study (SHADE-S)

Journal of Public Health, Journal Year: 2024, Volume and Issue: 46(2), P. 256 - 266

Published: Jan. 30, 2024

Abstract Background efficacy of therapeutic cholecalciferol supplementation for severe COVID-19 is sparingly studied. Objective effect single high-dose on sequential organ failure assessment (SOFA) score in moderate-to-severe COVID-19. Methods participants with moderate to PaO2/FiO2 ratio < 200 were randomized 0.6 million IU oral (intervention) or placebo. Outcomes primary outcome was change Day 7 SOFA and pre-specified secondary outcomes 28-day all-cause mortality. Results all, 90 patients (45 each group) included intention-to-treat analysis. 25(OH)D3 levels 12 (10–16) 13 (12–18) ng/ml (P = 0.06) at baseline; 60 (55–65) 4 (1–7) by vitamin D placebo groups, respectively. The better the group [3 (95% CI, 2–5) versus 5 3–7), P 0.01, intergroup difference − 2 −4 −0.01); r 0.4]. A lower mortality [24% compared 44% 0.046)] observed D. Conclusions ICU admission can improve reduce in-hospital D-deficient ClinicalTrials.gov id: NCT04952857 registered dated July 2021. What already known this topic—vitamin has immunomodulatory role. Observational isolated intervention studies show some benefit Targeted not studied RCTs. study adds—high-dose (0.6 Million IU) increase 25(OH)D > 50 safe reduces score, How might affect research, practice policy—vitamin useful may be practiced.

Language: Английский

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The role of vitamin D in outcomes of critical care in COVID-19 patients: evidence from an umbrella meta-analysis of interventional and observational studies

Public Health Nutrition, Journal Year: 2024, Volume and Issue: 27(1)

Published: Jan. 1, 2024

Abstract Objectives: Several meta-analyses have suggested the beneficial effect of vitamin D on patients infected with severe acute respiratory syndrome coronavirus-2. This umbrella meta-analysis aims to evaluate influence supplementation clinical outcomes and mortality rate COVID-19 patients. Design: Present study was designed as an meta-analysis. The following international databases were systematically searched till March 2023: Web Science, PubMed, Scopus, Embase. Settings: Random-effects model employed perform Using AMSTAR critical evaluation tools, methodological quality included evaluated. Participants: Adult suffering from studied. Results: Overall, 13 summarising data 4 randomised controlled trial 9 observational studies identified in this review. Our findings revealed that status significantly reduced [Interventional studies: (ES = 0·42; 95 % CI: 0·10, 0·75, P < 0·001; I 2 20·4 %, 0·285) 1·99; 1·37, 2·62, 00·0 0·944). Also, deficiency increased risk infection disease severity among Conclusion: is a factor influencing rate, severity, admission intensive care unit being detached mechanical ventilation. It vital monitor all conditions including COVID

Language: Английский

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