Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 20, 2022

Bulbus fritillariae cirrhosae (BFC) is one of the most used Chinese medicines for lung disease, and exerts antitussive, expectorant, anti-inflammatory, anti-asthmatic, antioxidant effects, which an ideal therapeutic drug respiratory diseases such as ARDS, COPD, asthma, cancer, pulmonary tuberculosis. Through this review, it found that mechanism BFC on exhibits characteristics multi-components, multi-targets, multi-signaling pathways. In particular, potential in terms intervention "cytokine storm", STAT, NF-κB, MAPK signaling pathways, well renin-angiotensin system (RAS) ACE involved in. storm" SARS-CoV-2 infection there intense inflammatory response. ACE2 regulates RAS by degradation Ang II produced ACE, associated with SARS-CoV-2. For COVID-19, may be a drug? This review summarized research progress diseases, discussed development potentiality treatment explained chemical diversity biological significance alkaloids BFC, clarified material basis, molecular targets, pathways diseases. We hope can provide insights discovery anti-COVID-19.

Language: Английский

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Bovine-derived antibodies and camelid-derived nanobodies as biotherapeutic weapons against SARS-CoV-2 and its variants: A review article

International Journal of Surgery, Journal Year: 2022, Volume and Issue: 98, P. 106233 - 106233

Published: Jan. 19, 2022

Language: Английский

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Role of ethno-phytomedicine knowledge in healthcare of COVID-19: advances in traditional phytomedicine perspective

Beni-Suef University Journal of Basic and Applied Sciences, Journal Year: 2022, Volume and Issue: 11(1)

Published: Aug. 4, 2022

Abstract Background Since the outbreak of COVID-19 virus, ethnomedicinal plants have been used in diverse geographical locations for their purported prophylactic and pharmacological effects. Medicinal relied on by people around globe centuries, as 80% world’s population rely herbal medicines some aspect primary health care needs, according to World Health Organization. Main body This review portrays advances traditional phytomedicine bridging knowledge ethno-phytomedicine healthcare. Ethnomedicinal symptoms related antiviral, anti-infective, anti-inflammatory, anti-oxidant, antipyretic, lung–gut immune boosters. Traditionally medicinal ability inhibit virus entry viral assembly, bind spike proteins, membrane block replications enzymes. The efficacy terms management can be evaluated vitro, vivo well different silico techniques (molecular docking, molecular dynamics simulations, machine learning, etc.) which applied extensively quest design effective biotherapeutics rapidly. Other phytomedicines against are controlled clinical trials, notably roles gut microbiome. Targeting microbiome via prebiotics is also found an alternative potential strategy search a combat strategy. Conclusions sources modern development, it essential build collaborations among ethnobotanists, scientists, technologists toward developing most efficient safest adjuvant therapeutics pandemic twenty-first century, COVID-19.

Language: Английский

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The Prevalence of COVID-19 in Europe by the End of November 2022: A Cross-Sectional Study

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Background The world has been affected differently by the coronavirus disease 2019 (COVID-19), and Europe reaped largest number of cases deaths. Moreover, COVID-19 statistics are dynamic. Objectives current study aimed to use data examine prevalence in end November 2022 compare findings globally. Methods primary on for each European country were obtained from “Worldometer” website. include cumulative incidence per country, deaths, total tests performed, million population, deaths million, population. case-fatality rate was calculated (number deaths/number cases). In addition, median age vaccination coverage (people who received two doses) extracted “United Nations” website “Our World Data” website, respectively. To countries globe, continent obtained. analysis variance (ANOVA) test used variances across means four parts based geographic division. An independent sample t-test also between Union (EU) states non-EU states. Spearman correlation coefficient determine relationship different variables Europe. Results As December 1, 2022, about 648 6.6 have recorded worldwide. accounted nearly 36.8% 29.5% all Based most after South America. Nearly 6.8 billion conducted worldwide, 41% done Europe; 43 performed more than their However, inconsistent A significant difference noticed Eastern others, especially Northern Western By affiliation with EU, there no difference. For global comparison, mean population higher those world’s countries, although they a lower (CFR). Thirteen among 15 worldwide located Southern significantly proportional performed. Conclusions had COVID-19, even though it accounts 9.4% Europe, others. Given natural immunity acquired during three years excellent vaccine is essential reconsider definition suspected case establish specific criteria testing.

Language: Английский

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Predictors of mortality in severe and critical coronavirus disease 2019 patients: Mansoura University Hospital experience

Egyptian Journal of Chest Diseases and Tuberculosis, Journal Year: 2025, Volume and Issue: 74(2), P. 221 - 228

Published: April 1, 2025

Background Coronaviruses are important human and animal pathogens. Certain demographic factors were linked with a higher rate of severe clinical course coronavirus disease 2019. The objective our study was to assess predictors mortality in patients having severe/critical 2019 isolated Mansoura University isolation hospital. Results It found that, 115 (38.3%) out 300 died. Mortality significantly associated older age (64.52 ± 12.70 for dead compared 56.45 13.29 years survivors) but not sex. In study, smoking, hypertension, ischemic heart disease, chronic renal malignancy diabetes or liver disease. Additionally, specific laboratory markers, such as lower hemoglobin, platelets count, lymphocyte percentages, lymphocyte/C-reactive protein (CRP) ratio, well neutrophil N/L CRP, ferritin, lactate dehydrogenase, aspartate transaminase (AST), need invasive mechanical ventilation risk. Also, statistically significant increase CT severity score. Conclusion only score, dehydrogenase PaCO 2 .

Language: Английский

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Profile of Egyptian pediatrics with COVID-19: insights from healthcare providers in Egypt

Egyptian Pediatric Association Gazette, Journal Year: 2025, Volume and Issue: 73(1)

Published: Feb. 2, 2025

Abstract Background The COVID-19 global pandemic significantly impacted populations of all ages. While initially thought to affect adults predominantly, it became clear that children and adolescents were also susceptible the virus's effects. This study aims explore epidemiological patterns, clinical features, laboratory radiological characteristics, outcomes infection in a group Egyptian (≤ 18 years). Methods observational, cross-sectional is based on multicenter questionnaire sent pediatricians managing COVID-19-infected children, through convenient sampling approach. picture investigations 253 pediatric cases included. Results Most (42%) occurred aged 3–10 years, slightly higher incidence males. Eighty-two percent presented with fever; most patients had lymphopenia elevated CRP, 59% 74%, respectively. common CT chest finding (done for 85 patients) was bilateral ground glass appearance, which appeared almost 45% patients. disease severity infants < 1 year. Severe critical forms associated high ferritin d-dimer. varied, under one year age having highest percentage severe cases, 15% mortality rate, when compared other groups. Conclusion has wide spectrum diseases ranging from asymptomatic critical. In death more among those d-dimer levels. Infants are vulnerable disease.

Language: Английский

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Vitamin D as an Adjuvant Immune Enhancer to SARS-Cov-2 Vaccine

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(3)

Published: Feb. 7, 2025

Language: Английский

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Incidence of common respiratory pathogens among patients with severe acute respiratory infection during COVID-19 pandemic in Egypt

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: May 5, 2025

Language: Английский

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Patterns and outcomes of acute toxicological cases before, during, and after COVID-19 lockdown in Sohag University hospitals, Egypt

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(2)

Published: March 1, 2024

Abstract Background Toxicologists manage poisoning by preventing, detecting, and treating it, which requires continuous data collection analysis of toxicological hazards. Aim the work The study aims to report compare pattern outcome acute cases admitted Sohag University Hospitals during COVID-19 lockdown (2020–2021) with year before (2019) after (2022). Methods This comparative reviewed sociodemographic clinical in medical records. showed that received 670 between 2019 2022; 105 2019, 347 2020–2021, 218 2022. Results Most patients were below seven years no sex differences. Accidental was most frequent toxicity. oral route common three studied periods. During lockdown, metal phosphide (19.0%), while therapeutic agents reported (23.9%). delay time a significant difference periods (p-value &lt; 0.001). In periods, complete recovery achieved more than 70% cases; however, mortality rate complications period (10.4% 9.5%, respectively) almost twice those pandemic odds ratio (OR) 0.07 CI 95% (0.02, 0.11). Conclusion had bad impact on outcomes as highest percentage compared

Language: Английский

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Impact of COVID-19 pandemic on care of maintenance hemodialysis patients: a multicenter study

Clinical and Experimental Nephrology, Journal Year: 2024, Volume and Issue: 28(10), P. 1040 - 1050

Published: May 3, 2024

Abstract Background The COVID-19 pandemic posed a challenge to hemodialysis (HD) patients. While most outpatient and elective medical services stopped during lockdown, HD patients continued visit their dialysis centers. We aimed assess how the initial phase of affected patient care by comparing adequacy other parameters before first 10 months pandemic. Methods In retrospective multi-center observational study, all adult in five centers Alexandria, Egypt were included. Dialysis adequacy, missed sessions, laboratory hospitalization recorded. Data after compared predictors determined. Results 388 included number sessions was higher with peaks second wave ratio nurses, phosphorus parathormone levels significantly pandemic, while urea reduction ratio, Kt/V , hemoglobin, calcium albumin lower. who reported difficult accessibility, lockdown. Hospital admissions doubled infection being main cause (45.5%). Number per nurse interdialytic weight gain inadequate dialysis. Conclusion its related lockdown negatively multiple aspects care. Continued access optimum should be priority any future mass events.

Language: Английский

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