Beyond Metabolic Messengers: Bile Acids and TGR5 as Pharmacotherapeutic Intervention for Psychiatric Disorders

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107564 - 107564

Published: Dec. 1, 2024

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed current treatments. This review explores emerging role of bile acids TGR5 receptor in pathophysiology psychiatric conditions, emphasizing their signaling within gut-brain axis. We detail synthesis systemic functions acids, transformation gut microbiota, impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety schizophrenia, autism spectrum bipolar disorder. The highlights how dysbiosis altered acid metabolism contribute to development exacerbation these through mechanisms involving inflammation, oxidative stress, neurotransmitter dysregulation. Importantly, we both pharmacological non-pharmacological interventions that modulate signaling, offering potential breakthroughs treatment strategies. These include dietary adjustments enhance beneficial production use specific agonists have shown promise preclinical clinical settings for regulatory effects on critical pathways such as cAMP-PKA, NRF2-mediated antioxidant responses, neuroinflammation. By integrating findings from dynamics metabolism, related events, this underscores cutting-edge therapeutic approaches poised revolutionize management disorders.

Language: Английский

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Can physical exercise help people with irritable bowel syndrome? How substantial is the evidence?

Health sport rehabilitation, Journal Year: 2023, Volume and Issue: 9(4), P. 94 - 110

Published: Dec. 30, 2023

Purpose: Irritable bowel syndrome is one of the most common gastrointestinal disorders worldwide that negatively affect health and quality life imposes high costs. Increasing attention being paid to non-pharmacological therapies, like physical exercise, manage alleviate irritable symptoms, but underlying mechanism unclear, evidence inconclusive. This article aims provide an overview analysis recent links exercise with symptoms. Material methods. For last five years research (2018-2023), we searched several international scientific databases, including Web Science, Scopus, Science Direct, ADI, Cochrane Central Register Controlled Trials, PubMed, Medline, Clinical trials.gov, Google Scholar, WHO database. Results. Generally, exerts variable effects on gut physiology, integrity, health. Much recommended adopting regular light-to-moderate aerobic relaxation anaerobic enhance patient’s psychological well-being global symptoms. These types are purported improve function, motility, tone, habits, immunity, microbial diversity, due a decrease in stress, depression, anxiety index, symptom severity score, intestinal hypersensitivity, permeability. In contrast, more studies reported disruptive vigorous integrity physiology can compromise symptoms by inducing splanchnic hypoperfusion, epithelial wall damage, malabsorption, dysbiosis, bacterial translocation, thus calling into question positive outcomes exercise. Conclusions. There overwhelming recommending exercises for patients IBS. However, this seems low-quality, making it challenging confirm actual impacts exercise. Ethnicity, study design, type intensity methodological issues among reasons put forward account low-quality evidence. Thus, well-designed plausible studies, particularly randomized controlled trials individualized intervention settings consider frequency, intensity, time, type, volume, progression, highly demanded enable drawing specific recommendations without adverse effects.

Language: Английский

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Mapping the current trends and hotspots on depression comorbid with insomnia: A bibliometric analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 7, 2024

Abstract Background Depression and insomnia often co-occur have a bidirectional relationship. This review utilized bibliometric visualized analysis to explore current research hotspots trends in this field identify future clinical practice directions. Methods To papers on the comorbidity of depression insomnia, researchers Web Science Core Collection (WoSCC). They employed tools such as CiteSpace, VOSviewer, Scimago Graphica visually analyze knowledge network authors, institutions, countries/regions, journals, cited references, keywords comorbid with insomnia. Results A total 697 were extracted from (WoSCC) Andrew D. Krystal being most influential author area. The University Pittsburgh United States emerged prolific institution country, respectively. Journal Affective Disorders was productive journal, primary including depression, anxiety, disorder, sleep. In terms co-citation analysis, Morin, Cm led field. top-cited journal Sleep, paper titled “Validation Insomnia Severity Index an outcome measure for research” ranked first. Finally, “Psychiatry”was frequent study category. Conclusions provides comprehensive overview highlights key areas focus, offering guidance clinicians selecting

Language: Английский

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Research Hotspots and Trends on Post-Stroke Depression: a Bibliometric Analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 18, 2024

Abstract Post-stroke depression (PSD) is a common neuropsychiatric consequence of stroke that can negatively impact cognitive function, somatic function recovery, and patient survival. This paper utilized bibliometric visualized analysis to explore current research hotspots trends in this field identify future clinical practice directions. Researchers the Web Science Core Collection (WoSCC) extract papers on PSD employed tools such as CiteSpace, VOSviewer, Scimago Graphica visually analyze knowledge network authors, institutions, countries/regions, journals, cited references, keywords. A total 850 were extracted from WoSCC, with Robinson, RG being identified most influential author area. The prolific institution was Wenzhou Medical University, China emerged leading country producing PSD. Journal Affective Disorders found be productive journal, primary keywords including poststroke depression, stroke, symptom. Co-citation researcher top-cited journal Stroke, titled “Poststroke Depression: Review” ranked cited. Finally, “Neurosciences & Neurology” frequent study category. provided valuable information hotspot frontier research, potential partners well reference points for topics development

Language: Английский

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Evidências científicas disponíveis acerca da relação da ansiedade e depressão nos casos de síndrome do intestino irritável

Revista Remecs - Revista Multidisciplinar de Estudos Científicos em Saúde, Journal Year: 2024, Volume and Issue: 9(15), P. 147 - 155

Published: Aug. 13, 2024

A Síndrome do Intestino Irritável (SII) é uma disfunção trato gastrointestinal sem etiologia definida. Estudos apontam o estresse emocional como um fator significativo, levando a necessidade de analisar ligação entre sistema nervoso central e gastrintestinal. O objetivo identificar as evidências disponíveis acerca da relação ansiedade depressão na SII. As buscas foram realizadas utilizando os Descritores em Ciências Saúde (DeCS) com operador proximidade operadores booleanos: irritable bowel syndrome AND anxiety depression Brain-Gut Axis. coleta dados aconteceu através material selecionado nas bases BVS, CAPES PUBMED. Foram incluídos artigos publicados anos 2018 2023 língua portuguesa, inglesa espanhol que estivessem íntegra abordassem tema. excluídos estudos não tratavam diretamente tema, teses, guidelines, resumos anais, revisão livros.Descritores: Irritável, Ansiedade, Depressão, Eixo Encéfalo-Intestino. Relationship between and in Abstract: Irritable Bowel Syndrome (IBS) is dysfunction of the tract with no defined etiology. Studies point to emotional stress significant factor, leading need analyze connection nervous systems. The objective identify available evidence about relationship IBS. searches were carried out using Health Sciences Descriptors proximity operator Boolean operators: (OR or NOT), Data collection took place through selected from VHL, PUBMED databases. Articles published Portuguese, English Spanish that full addressed topic included. did not directly address topic, theses, annal summaries, review articles books excluded.Descriptors: Syndrome, Anxiety, Depression, Relación ansiedad y depresión en el síndrome del intestino Resumen: es una disfunción sin etiología Los estudios señalan estrés un factor importante, lo lleva la necesidad analizar conexión los sistemas nervioso gastrointestinal. El evidencia disponible sobre relación Las búsquedas se realizaron Descriptores Ciencias Salud con proximidad La recolección datos realizó través seleccionado las Se incluyeron artículos portugués, inglés español estuvieran disponibles su totalidad abordaran excluyeron abordaron directamente tesis, guías, resúmenes anales, revisión libros.Descriptores: Colon Irritable, Ansiedad, Depresión, Eje Cerebro-Intestino.

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Examining the Relationship Between Anxiety, Depression, and Gastrointestinal Symptoms Among University Students: A Campus-Wide Survey Analysis

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

This study investigates the relationship between anxiety, depression, and gastrointestinal (GI) symptoms among university students through a comprehensive campus-wide survey.

Language: Английский

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IRRITABLE BOWEL SYNDROME MANAGEMENT: BUMPY ROAD FOR PHYSICIANS

Khyber Medical University Journal, Journal Year: 2023, Volume and Issue: unknown

Published: March 31, 2023

Irritable bowel syndrome is a complex gastrointestinal disorder related to over activity of nerves supplying the gut. 1It has been matter enormous concern for both patients and treating physicians’ .The clinical course diverse takes different twist turns. Sometimes it does present with typical symptoms like bloating, flatulence altered habits. At times there mental illness severe depression that comes in way which real challenge physicians treat as mere reassurance doesn’t suffice. The longer history symptoms, more complicated gets. There are multiple obstacles before making rows treatment.2 most frustrating point when patient fails show any improvement after months treatment. They have relapsing remitting manner. Post infectious IBS agonizing need antibiotics an era increasing resistance .3Failure one antibiotic resolve leads usage ones at same time cramping abdominal pain sleepless nights leading daytime fatigue do disastrous impact on activities daily living. After decades research, optimization treatment irritable still daunting task even experienced gastroenterologists.4 emergence alarm bleeding per rectum,uninetentional weight loss feeling mass individuals who years ring bell act vigilantly were otherwise complacent. 4They relying traditional regimens giving laxatives,anti spasmodic medications depression. Some them consider expeditious referral psychiatrist without getting bottom situation. Colonoscopy advised end much damaged caused already .It will be excellent practice stool routine examination ,culture.ESR,CRP calprotectin levels.5 give idea level inflammation gut invasive investigations always dangerous setting acute flare disease such inflammatory

Language: Английский

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KNOWLEDGE, PRACTICES AND ATTITUDES OF GENERAL PRACTITIONERS TOWARDS IRRITABLE BOWEL SYNDROME: A CROSS SECTIONAL STUDY

Journal of Population Therapeutics and Clinical Pharmacology, Journal Year: 2023, Volume and Issue: unknown, P. 261 - 267

Published: Dec. 8, 2023

Background: Irritable bowel syndrome (IBS) is a functional disorder that has colossal impact on the quality of life while patient’s views have been explored in detail large no. studies opinions general physicians need to as they are primary route referral medical specialists Objective: To assess knowledge, practices and attitudes practitioners towards irritable Materials Methods: This cross sectional study was conducted Peshawar after approval research proposal by committee MMC General Hospital 15th January 2023 t0 June .The inclusion criteria working different clinics hospitals The gastroenterologists were excluded from Total sample size 100 with non-probability convenient sampling technique . participants asked fill questionnaire explaining pros con study. data analysis done SPSS version 22. frequencies percentages applied for categorical where Mean SD quantitative data. Chi Square test taking p value 0.05 or less significant Results: mean age respondents 38 years equal male female ratio .58% urban areas rest them rural settings. knowledge questions assessed true, false don’t know. Regarding IBS hereditary disease 44% admitted it be 25% 31% affects only women rue responses 48%,32% 20% saying life-threatening 51% said true.27% 22% symptoms patients daily true about 43%, 34% 23% know answering Do you take your medications prescribed regularly? 58% yes 42% No, avoid gluten containing products (wheat ,barley rye) food might worsen symptoms? 65% Yes 35% perform yoga 48% 52% No. terms their can seen tables below. Significant association After following advice physician regarding diet, style, medications, do feel affected now 0.03 Conclusion: concluded had satisfactory level awareness good omen appropriate management trained experts field

Language: Английский

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