Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway

Journal of Ovarian Research, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 16, 2025

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of reproductive age. Anovulation one the most important clinical features PCOS, insulin resistance (IR) critical pathogenic factors. Woxuanzhongzhou (WXZZ) traditional herbal formulation that has shown efficacy treating PCOS combined with IR, but underlying mechanism not clear. The aim this study was to investigate molecular WXZZ on dehydroepiandrosterone sulfate high fat diet induced IR mice. 40 female C57BL/6 mice were randomized 4 groups: control group, model metformin group. Some by (DHEA) high-fat (HFD) for 3 weeks. Following induction, administered gavage. Body weight, fasting blood glucose (FBG), (FINS) levels, homeostatic assessment (HOMA-IR), gonadal hormones measured. Estrous cycles monitored. structure gastrocnemius muscle subcutaneous fatty tissue also evaluated. Additionally, serum irisin non-esterified acids (NEAF) levels protein gene expression AMPK, PGC1-α, FNDC5, CaMKK, UCP1 analyzed. DHEA + HFD group exhibited significant improvements several key parameters compared ameliorated disorders, resumed estrous cycle DHEAS diet-induced anovulatory Significant reductions observed body testosterone, luteinizing hormone, hormone/ follicle-stimulating hormone ratio, FINS, HOMA-IR. promoted secretion up-regulating AMPK/PGC1-α/FNDC5 up-regulated CaMKK/AMPK/PGC1-α/UCP1 fat. inhibited overproduction NEFA, reduced lipid accumulation. Structural analysis adipose revealed partial restoration. exhibits therapeutic effects These may be mediated through activation AMPK/PGC1-α pathway promote irisin.

Language: Английский

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Mapping the landscape of research on insulin resistance: a visualization analysis of randomized clinical trials

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 9, 2024

Abstract Background Insulin resistance, a condition in which cells do not respond adequately to insulin, plays crucial role diabetes and related metabolic disorders. Randomized clinical trials (RCTs) explore interventions manage insulin contributing evidence-based medical progress. The current study aimed analyze the global research landscape trends RCTs targeting resistance. Methods This used bibliometric analysis data visualization examine RCT publications on resistance from 2003 2022. Scopus database was due its comprehensive coverage. search strategy involved combining terms with RCT-related terms. query validated, core indicators were publication growth, origin, productivity, quality, citations. Results Between 2022, 1077 RCT-focused identified pool of 24,932 articles. growth followed two phases, significant increase after 2008. USA ( n = 308; 28.60%), Iran 165; 15.32%), China 110; 10.21%), UK 92; 8.54%) main contributors. active institutions included Tehran University Medical Sciences 38; 3.53%) Harvard School 31; 2.88%). Prominent funding agencies include National Institutes Health 88; 8.17%) Institute Diabetes Digestive Kidney Diseases 86; 7.99%). top journals American Journal Clinical Nutrition 44; 4.09%) Care 35; 3.25%). Co-occurrence revealed three clusters addressing “utilizing lipid panels as resistance,” “analyzing impact diet composition physical activity sensitivity among obese individuals,” “exploring cases polycystic ovary syndrome.” Conclusions highlights Research panels, impact, patients syndrome will continue be hotspot. findings offer valuable information priorities, international collaborations, impactful publications. provides foundation for future directorial investigations this critical area health.

Language: Английский

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Liraglutide and polycystic ovary syndrome: is it only a matter of body weight?

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 46(9), P. 1761 - 1774

Published: April 24, 2023

Despite Polycystic Ovary Syndrome (PCOS) is a very prevalent disorder among women of reproductive age, there widespread agreement that until now, no pharmacological options are available to tackle the entire spectrum clinical manifestations encountered in practice. Obesity and insulin resistance, which commonly characterized this syndrome, prompted design studies investigating effects glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RA) PCOS. Indeed, impressive number randomized controlled trials (RCTs) systematic reviews provided robust evidence on effectiveness GLP-1RA PCOS as new, appealing approach, producing both satisfactory permanent weight loss, improvement resistance at same time. However, most subjects included RCTs patients with obesity/overweight, whereas portion women, can even reach 50%, might present lean phenotype. Moreover, some benefits metabolic features may not have fully emerged due low or medium doses employed vast majority current studies. Thus, pitfalls methodology these led sometimes misleading results. In addition, aspects GLP-1 beyond such preclinical directly modulating hypothalamus-pituitary-gonadal axis, biochemical expression hyperandrogenism, still deserve greater insight, especially light possible therapeutic use independently obesity. Aim review further unravel role pathogenesis, tempting provide additional supports rationale treatment management also independent loss. For purpose, outcomes anthropometric changes been treated separately better underpin RA, particular liraglutide,

Language: Английский

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Association between waist circumference and female infertility in the United States

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(12), P. e0295360 - e0295360

Published: Dec. 20, 2023

Obesity has significant implications for fertility and reproductive health. However, evidences linking abdominal obesity to female infertility were limited inconclusive. Our objective was figure out the potential relationship between waist circumference (WC) among women of childbearing age in United States using data from National Health Nutrition Examination Survey (NHANES).Our cross-sectional study included 3239 participants aged 18-45 years. To explore independent WC infertility, weighted multivariable logistic regression smoothed curve fitting performed. Interaction subgroup analyzes then conducted secondary analysis.WC positively associated with BMI after adjusting other confounders. In fully adjusted model, every 1cm increase circumference, risk increased by 3% (OR = 1.03, 95% CI: 1.01-1.06). When divided into five equal groups, highest quintile had 2.64 times than that lowest 2.64, 1.31-5.30). Smooth revealed a non-linear but dose-dependent infertility. Furthermore, we found an inverted U-shaped (turning point: 113.5 cm) who moderate recreational activities J-shaped 103 deficient activities.Waist is positive predictor BMI. Moderate can lower obesity.

Language: Английский

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Influence of Sociodemographic Variables and Healthy Habits on the Values of Insulin Resistance Indicators in 386,924 Spanish Workers

Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5122 - 5122

Published: Dec. 16, 2023

Insulin resistance (IR) is an alteration of the action insulin in cells, which do not respond adequately to this action, leading increase blood glucose levels. IR produces a very diverse clinical picture and increases cardiometabolic risk population that suffers from it. Among factors influence are genetics, unhealthy lifestyle habits, overweight, obesity. The objective work was determine how different sociodemographic variables healthy habits values scales assess presenting group Spanish workers. An observational, cross-sectional, descriptive study carried out 386,924 workers regions. Different were studied (age, social class, educational level, smoking, Mediterranean diet, physical exercise) along with their association four evaluate (TyG index, TyG-BMI, METS-IR, TG/HDL-c). To analyse quantitative variables, Student's t test used, while Chi-squared used for qualitative variables. A multinomial logistic regression analysis performed, calculating odds ratio its 95% confidence intervals. accepted level statistical significance set at p < 0.05. In multivariate analysis, all except increased high on scales, especially sedentary low adherence diet. Our results demonstrate between practice regular exercise reduction IR; strong role diet as protective factor aging IR, has also been suggested other studies; and, finally, relationship socioeconomic IR.

Language: Английский

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Combined Nutrition with Exercise: Fueling the Fight Against Sarcopenia Through a Bibliometric Analysis and Review

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 1861 - 1876

Published: May 1, 2024

Objective: This bibliometric analysis and review aimed to examine the current research status trends in combination of nutrition exercise training for sarcopenia. Additionally, it sought provide researchers with future directions this field. Methods: Relevant publications were obtained from Web Science Core Collection (WoSCC) database, covering period January 1995 October 2023. The collected analyzed using CiteSpace, VOSviewer, Bibliometrix, Review Manager. Results: Out 2528 retrieved publications, United States emerged as leading contributor terms publication volume. University Texas System was identified most productive institution. Luc J C van Loon published author Analysis keywords revealed recent hot topics emerging areas interest, such "gut microbiota" "mechanisms". Upon further evaluation, resistance (RT) protein supplementation commonly employed effective methods. Conclusion: RT are widely recognized strategies. Future should focus on investigating molecular aspects Moreover, potential therapeutic role gut microbiota sarcopenia requires comprehensive investigation human subjects establish its correlation. Keywords: sarcopenia, nutrition, exercise, analysis,

Language: Английский

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Comparative Analysis of Psychosocial Outcomes and Quality of Life Among Nulligravida, Primigravida, and Multigravida Women Diagnosed With Polycystic Ovary Syndrome (PCOS)

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Background Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that significantly impacts women's physical and mental health. While its metabolic reproductive effects are well-documented, psychosocial impact-particularly across different stages-remains underexplored. Gravidity may influence psychological outcomes, with nulligravida women facing fertility-related distress, primigravida experiencing pregnancy-related anxiety, multigravida dealing cumulative stress worsening PCOS symptoms. This study aims to compare depression, stress, quality of life (QoL) among these groups inform targeted, stage-specific interventions improve well-being in PCOS. Objective nulligravida, primigravida, The findings will the development targeted address specific needs each group. Methods cross-sectional study, conducted from July 2023 December 2024 at Mardan Medical Complex, involved aged 18-45 diagnosed based on established clinical guidelines. Participants were systematically sampled categorized by pregnancy history into groups. Validated instruments used assess life. data analyzed using Kruskal-Wallis one-way ANOVA other relevant statistical methods outcomes Results In this 510 PCOS, significant differences observed three gravidity Multigravida had highest mean age (32.57±4.76 years) prevalence family (40; 57.14%). Primigravida exhibited BMI (31.21±3.82) reported most favorable life, 56 (20.51%) rating it as Good. However, group also levels severe 211 (77.29%) reporting it. Severe depression was women, 119 (71.26%) it, while poorest 45 (64.29%) Poor 28 (40%) Very Poor. levels, 71 (71.43%) patients high experienced symptoms, including hirsutism 25 (35.71%) acne 37 (52.85%) patients. comparison, 49 (29.34%) 46 (16.85%) present 61 (36.53%) 139 (50.92%) women. Conclusion These highlight vital importance personalized, care effective management ensuring responsive distinct challenges encountered various stages.

Language: Английский

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To Explore the Mechanism of PCOS with Osteoporosis from the Perspective of Abnormal Bone Metabolism

Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(01), P. 882 - 887

Published: Jan. 1, 2025

Language: Английский

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Bibliometrics And Visualisation Analysis Of Literature On Intrauterin Insemination In Obstetrics Gynecology Research Area (2013-2023)

Medical Science and Discovery, Journal Year: 2025, Volume and Issue: 12(3), P. 82 - 92

Published: March 16, 2025

Objective: Intrauterine insemination (IUI) is a non-invasive, cost-effective assisted reproductive technique widely recognized as the primary intervention and first-line treatment for unexplained infertility. However, no comprehensive bibliometric studies have been conducted to analyze latest findings developments in this field. This study aims evaluate scientific literature on IUI. Materials Methods: utilized Web of Science database identify articles related All search results were exported cited plain text formats create source files analysis. The data then examined using Biblioshiny (version 2.0) VOSviewer software. analysis covered annual publication trends, authorship distribution by country academic institution, journal distribution, author productivity, keyword usage. Results: As October 1, 2023, SCIE contained 24,835 publications, with 18,425 published since 2000 9,750 2013. After filtering, 964 from 55 different sources analyzed. dataset, spanning 2013 had mean document age 5.21 years an average 14.95 citations per document, growth rate 5.27%. United States, Netherlands, China top three contributing countries. Leading affiliations included University Amsterdam, Harvard University, McGill University. "Fertility Sterility" "Human Reproduction" most frequently journals. Keyword identified key terms IUI research, highlighting emerging trends research priorities. Conclusions: provides overview current state research. offer valuable insights into collaboration patterns, hotspots, frontiers, which may benefit researchers clinicians

Language: Английский

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Trends in metabolic dysfunction in polycystic ovary syndrome: a bibliometric analysis

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 28, 2023

Polycystic ovary syndrome (PCOS) is a very common chronic disease and causes reproductive disorders in women of childbearing age worldwide. The cause metabolic dysfunction PCOS unknown, there lack systematic bibliometric analysis for this disease. This study included 3,972 articles on published from 2012 to 2021. We applied the VOSviewer CiteSpace scientometric software analyze data regarding publication articles, countries, authors, institutions, scientific categories, cited journals, keywords. Through analysis, we determined research efforts their developing trends anticipated progress understanding PCOS-related dysfunction.

Language: Английский

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