Brain Insulin Resistance in Neurological Disorders of Various Genesis: Current State and Treatment Approaches DOI
И. И. Зорина,

A. O. Shpakov

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(4), P. 603 - 616

Published: Dec. 1, 2024

Language: Английский

Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study DOI Creative Commons
Ruiying Zhang, Hong Jiang,

Yaoling Wu

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 6, 2025

Triglyceride glucose index(TyG) and a body shape index(ABSI) are both independent predictor of stroke incidence or adverse prognosis but these two indicators seldom were combined to predict. The purpose this study is evaluate whether the combination TyG ABSI better predict stroke. Based on China Health Retirement Longitudinal Study(CHARLS), 8,257 people aged 45 years older without enrolled followed up 9 years. Sociodemographic information, health status, physical examination blood data collected retrospectively. Cox regressions determine relationship between different groups incidence, using receiver operating characteristic curves diagnostic value. Meanwhile, subgroup analysis was performed investigate prediction performance among population. 672(8.14%) participants had during In adjusted multivariate cox regression model, still predictors HR 1.25(95%CI: 1.06-1.47) 1.33(95%CI: 1.06-1.68). Restricted cubic spline showed associations highest efficacy(AUC: 0.579, 95%CI: 0.553-0.597), compared TyG(AUC:0.566, 0.544-0.587) ABSI(AUC:0.533, 0.524-0.597). Kaplan-Meier that cumulative with high ABSI(TyG ≥ 8.5742, 0.0852; P < 0.0001), which incidence(HR:1.64, 95%CI:1.2-2.24). higher clinical value enabled earlier detection in general population, could be monitored intervened reduce overall burden

Language: Английский

Citations

3

Mapping the landscape of research on insulin resistance: a visualization analysis of randomized clinical trials DOI Creative Commons
Sa’ed H. Zyoud

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Jan. 9, 2024

Abstract Background Insulin resistance, a condition in which cells do not respond adequately to insulin, plays crucial role diabetes and related metabolic disorders. Randomized clinical trials (RCTs) explore interventions manage insulin contributing evidence-based medical progress. The current study aimed analyze the global research landscape trends RCTs targeting resistance. Methods This used bibliometric analysis data visualization examine RCT publications on resistance from 2003 2022. Scopus database was due its comprehensive coverage. search strategy involved combining terms with RCT-related terms. query validated, core indicators were publication growth, origin, productivity, quality, citations. Results Between 2022, 1077 RCT-focused identified pool of 24,932 articles. growth followed two phases, significant increase after 2008. USA ( n = 308; 28.60%), Iran 165; 15.32%), China 110; 10.21%), UK 92; 8.54%) main contributors. active institutions included Tehran University Medical Sciences 38; 3.53%) Harvard School 31; 2.88%). Prominent funding agencies include National Institutes Health 88; 8.17%) Institute Diabetes Digestive Kidney Diseases 86; 7.99%). top journals American Journal Clinical Nutrition 44; 4.09%) Care 35; 3.25%). Co-occurrence revealed three clusters addressing “utilizing lipid panels as resistance,” “analyzing impact diet composition physical activity sensitivity among obese individuals,” “exploring cases polycystic ovary syndrome.” Conclusions highlights Research panels, impact, patients syndrome will continue be hotspot. findings offer valuable information priorities, international collaborations, impactful publications. provides foundation for future directorial investigations this critical area health.

Language: Английский

Citations

5

Associations between Life’s Essential 8 and post-stroke depression and all-cause mortality among US adults DOI Creative Commons

Ruicong Ma,

Junting Song,

Yanchun Ding

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: April 12, 2024

Abstract Background Depression is the common mental disease after stroke. Our objective was to investigate correlation of Life’s Essential 8 (LE8), recently updated evaluation cardiovascular health, with occurrence post-stroke depression (PSD) and all-cause mortality among United States (US) adults. Methods Participants stroke were chosen from National Health Nutrition Examination Survey (NHANES) between 2005 2018. The relationship LE8 risk PSD assessed through weighted multiple logistic models. A restricted cubic spline employed for examination correlations. To demonstrate stability results, sensitivity analysis subgroup carried out. Furthermore, Cox regression models used mortality. Results In this study, a total 1071 participants included analysis. It observed that score shared an inverse in per 10 points increase [OR = 0.62 (0.52–0.74, P < 0.001)] demonstrated approximately noticeable linear association risk. Sensitivity verified findings. Moreover, no statistically significant interactions identified reverse also 10-point [HR 0.85 (0.78–0.94, cox Conclusions negative discovered US We need conduct large-scale prospective studies further validate our results.

Language: Английский

Citations

5

Mapping the Landscape of Internet Pornography, Loneliness, and Social Media Addiction: A CiteSpace Bibliometric Analysis DOI
Abhishek Prasad,

S. Kadhiravan

International Journal of Mental Health and Addiction, Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Language: Английский

Citations

4

Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions DOI Open Access
Rashid Mir, Mohammed Jeelani, Muffarah Hamid Alharthi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2770 - 2770

Published: March 19, 2025

Insulin resistance (IR) is a significant factor in the development and progression of metabolic-related diseases like dyslipidemia, T2DM, hypertension, nonalcoholic fatty liver disease, cardiovascular cerebrovascular disorders, cancer. The pathogenesis IR depends on multiple factors, including age, genetic predisposition, obesity, oxidative stress, among others. Abnormalities insulin-signaling cascade lead to host, insulin receptor abnormalities, internal environment disturbances, metabolic alterations muscle, liver, cellular organelles. complex multifaceted characteristics signaling envisage their thorough comprehensive understanding at molecular level. Therapeutic strategies for include exercise, dietary interventions, pharmacotherapy. However, there are still gaps be addressed, more precise biomarkers associated chronic lifestyle interventions needed. Understanding these pathways essential developing effective treatments IR, reducing healthcare costs, improving quality patient life.

Language: Английский

Citations

0

Study on the Comorbid Mechanisms of Sarcopenia and Late-Life Depression DOI

Jiale Wu,

Jun Tang, Di Huang

et al.

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 115538 - 115538

Published: March 1, 2025

Language: Английский

Citations

0

Accelerometer‐Measured Behavior Patterns in Incident Cerebrovascular Disease: Insights for Preventative Monitoring From the UK Biobank DOI Creative Commons
Stephanie Zawada, Ali Ganjizadeh, Gian Marco Conte

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(11)

Published: May 31, 2024

The goal was to compare patterns of physical activity (PA) behaviors (sedentary behavior [SB], light PA, moderate-to-vigorous PA [MVPA], and sleep) measured via accelerometers for 7 days between patients with incident cerebrovascular disease (CeVD) (n=2141) controls (n=73 938).

Language: Английский

Citations

2

A visualization analysis of hotspots and global trends on pelvic floor dysfunction in cervical cancer DOI Creative Commons
Jiawen Wang, Xinhao Wang, Tianming Ma

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(2)

Published: Jan. 30, 2024

Abstract Background/objective Cervical cancer is the major cause of cancer-related mortalities in women globally. It constitutes one life-threatening conditions for developing countries. The popularization cervical screening and improvement treatment levels has caused mortality rate to decrease gradually, but pelvic floor dysfunction before after become prominent attracted more attention. Bibliometric analysis been carried out this research. main goal research provide a comprehensive insight into knowledge structure global hotspots about cancer. Methods Literature related as May 2023 was searched on Web Science Core Collection (WOSCC). visualization bibliometric analyses number contents publications were performed analyze temporal trends, spatial distribution, collaborative networks, influential references, keyword co-occurrence, clustering. Results There 870 from 74 countries or regions, with U.S. leading position. Since 2020, rapidly increased emphasis quality life patients. Although mainly occurs countries, developed have made great contributions disease. However, such China India, needs be improved. In field, studies focused sexual urinary incontinence patients, most cited papers discussed effect activities females. frontier keywords represented by radiotherapy risk factors. Conclusion This study provides an objective literature available identifies future trends current hotspots. can valuable reference researchers field.

Language: Английский

Citations

2

Research hotspots and frontiers in non-specific low back pain: a bibliometric analysis DOI Creative Commons

Qiangjian Mao,

Yuqing Wang, Shiqi Xu

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 30, 2024

Extensive research has been conducted worldwide on non-specific low back pain (NSLBP), some researchers published a bibliometric analysis of NSLBP in 2020, but there have no supplements or updates since then. Therefore, this study aimed to analyze the hotspots and frontiers over last decade.

Language: Английский

Citations

2

Insulin resistance: Risk factors, diagnostic approaches and mathematical models for clinical practice, epidemiological studies, and beyond DOI
Janusz Krzymień, Piotr Ładyżyński

Journal of Applied Biomedicine, Journal Year: 2023, Volume and Issue: 44(1), P. 55 - 67

Published: Dec. 26, 2023

Language: Английский

Citations

6