Prevalence and trends of polypharmacy in U.S. adults, 1999–2018

Global Health Research and Policy, Journal Year: 2023, Volume and Issue: 8(1)

Published: July 12, 2023

Abstract Background Polypharmacy is one of the most important health issues for its potential impacts on disease burden and healthcare costs. The aim this study was to update a comprehensive picture prevalence trends in polypharmacy over 20 years U.S. adults. Methods Participants included 55,081 adults aged ≥ from National Health Nutrition Examination Survey, January 1, 1999, through December 31, 2018. simultaneously use 5 drugs individual defined as polypharmacy. were evaluated among within different demo-socioeconomic status pre-existing diseases. Results From 1999–2000 2017–2018, overall percentages with remained rise, increasing 8.2% (7.2–9.2%) 17.1% (15.7–18.5%) (average annual percentage change [AAPC] = 2.9%, P .001). considerably higher elderly (from 23.5% 44.1%), heart 40.6% 61.7%), diabetes 36.3% 57.7%). Also, we observed greater increase rate men (AAPC 4.1%, < .001), Mexican American 6.3%, non-Hispanic Black 4.4%, Conclusions continually especially older, patients disease, or diabetes. high urges providers policymakers manage specific population groups.

Language: Английский

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Cardiac and Renal Comorbidities in Aging People Living With HIV

Circulation Research, Journal Year: 2024, Volume and Issue: 134(11), P. 1636 - 1660

Published: May 23, 2024

Contemporary World Health Organization data indicates that ≈39 million people are living with the human immunodeficiency virus. Of these, 24 have been reported to successfully accessed combination antiretroviral therapy. In 1996, endorsed widespread use of therapy, transforming virus infection from being a life-threatening disease chronic illness characterized by multiple comorbidities. The increased access therapy has translated (PLWH) no longer having reduced life expectancy. Although aging as biological process increases exposure oxidative stress and subsequent systemic inflammation, this effect is likely enhanced in PLWH they age. This narrative review engages intricate interplay between associated cardiac renal comorbidities development PLWH. We examine evolving demographic profile PLWH, emphasizing increasing prevalence individuals within population. A central focus discusses pathophysiological mechanisms underpin heightened susceptibility diseases

Language: Английский

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Polypharmacy and its association with dementia, Parkinson’s disease, and mortality risk in UK adults: a multistate modeling approach

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Polypharmacy is common among older adults and has been linked to adverse outcomes such as dementia, Parkinson’s disease (PD), mortality. However, its influence on transitions between these health states remains understudied in large, population-based cohorts. Using data from 361,970 UK Biobank participants aged 50 with up 15 years of follow-up, we examined the association polypharmacy, defined use five or more medications, states: healthy, PD, Multistate parametric models, including Weibull regression, were employed estimate associations, adjusting for demographics, socioeconomic status, cardiovascular health, comorbidities. Latent class analysis was used identify specific medication combinations associated transitions. significantly higher risks transitioning healthy dementia (hazard ratio [HR], 1.15; 95% CI, 1.07–1.23) death (HR, 1.11; 1.08–1.09). Women exhibited better but polypharmacy prevalence compared men. revealed that certain combinations, omega-3 fatty acids multivitamins, inversely mortality, independent status. These findings highlight complex relationship adults. Careful management may mitigate particularly individuals at risk neurodegenerative diseases. Further research warranted investigate potential protective effects outcomes.

Language: Английский

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Association between polypharmacy and chronic kidney disease among community-dwelling older people: a longitudinal study in southern China

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: May 17, 2024

Abstract Background Polypharmacy would increase the risk of adverse drug events and burden renal excretion among older people. Nevertheless, association between number medication chronic kidney disease (CKD) remains controversial. Therefore, this study aims to investigate incidence CKD in Methods This investigates medications 2672 elderly people (≥ 65 years older) community health service center southern China 2019 2022. Logistic regression analysis was used evaluate relationship polypharmacy CKD. Results At baseline, average age subjects 71.86 ± 4.60, 61.2% were females, 53 (2.0%) suffer from polypharmacy. During an follow-up 3 years, new-onset developed 413 (15.5%) participants. revealed that taking a higher associated with Compared who didn’t take medication, observed taken more than five (OR 3.731, 95% CI 1.988, 7.003), followed by those four 1.621, 1.041, 2.525), three 1.696, 1.178, 2.441), two drugs 1.585, 1.167, 2.153), or one 1.503, 1.097, 2.053). Furthermore, age, systolic blood pressure (SBP), white cell (WBC), urea nitrogen (BUN) triglyceride (TG) also independent factors ( P < 0.05). Conclusion The As increased, increased.

Language: Английский

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Polypharmacy Is Associated with Sociodemographic Factors and Socioeconomic Status in United States Adults

Pharmacy, Journal Year: 2024, Volume and Issue: 12(2), P. 49 - 49

Published: March 12, 2024

A thorough understanding of polypharmacy is required to create public health initiatives that minimize the potential for adverse outcomes. This study aimed investigate relationship between sociodemographic factors, socioeconomic status (SES), and risk in United States (US) individuals 1999–2000 2017–2018. The cross-sectional National Health Nutrition Examination Survey dataset covered ten cycles All aged ≥18 years were included. simultaneous use at least five medications by one person known as polypharmacy. Multivariable logistic regression showed there was a statistically significant association factors (such age 45 64 (odds ratio [OR] = 3.76; 95% confidence interval [CI] 3.60–3.92; p < 0.0001) 65 or above (OR 3.96; CI 3.79–4.13; 0.0001), especially women 1.09; 1.06–1.13; non-Hispanic blacks 1.66; 1.51–1.83; veterans 1.27; 1.22–1.31; 0.0001)) SES being married 1.14; 1.08–1.19; 0.031), widowed, divorced, separated 1.21; 1.15–1.26; college graduate 1.21, 1.15–1.27, earning > USD 55,000 per year 1.86; 1.79–1.93; 0.0001)). Individuals above, women, with higher educational levels yearly incomes more likely experience US

Language: Английский

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Polifarmacia y efecto en riñones de adultos mayores

Acta Médica Grupo Ángeles, Journal Year: 2024, Volume and Issue: 22(3), P. 349 - 351

Published: Jan. 1, 2024

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Magnitude of multiple drug use and determinants of vulnerability among chronic kidney disease inpatients in Ethiopia: a multi-center study

BMC Nephrology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 7, 2024

Patients with chronic kidney disease frequently face various nutritional and metabolic problems that necessitate the use of multiple medications. This drug can lead to several drug-related including adverse events, hospital admissions, poor medication adherence, harmful interactions, inadequate therapeutic outcomes, death. Despite these challenges, there is a notable lack studies on extent its determinants among patients in Ethiopia. study aims assess magnitude identify vulnerability

Language: Английский

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Aggressive Intravenous Hydration and a Defined Plant-Based Diet Safely and Effectively Treated Type 5 Cardiorenal Syndrome with Stage E Heart Failure-Related Cardiogenic Shock: A Case Report

Reports — Medical Cases Images and Videos, Journal Year: 2024, Volume and Issue: 7(4), P. 94 - 94

Published: Nov. 8, 2024

Background and Clinical Significance: Heart failure kidney diseases often coexist are difficult to clinically manage. Dysfunction in either organ exacerbates dysfunction the other, potentially leading cardiorenal syndrome (CRS). CRS has five different subtypes, with type 5 being most problematic given that it consists of an acute insult superimposed upon chronic CRS. Additionally, can be complicated by heart failure-related cardiogenic shock (HF-CS), which is associated increased hospitalizations a high 1-year mortality rate. The standard treatment for patients HF-CS guideline-directed medical therapy reduced ejection fraction (HFrEF) as tolerated, along inotropic therapies surgical mechanical left ventricular (LV) support, guided invasive hemodynamic monitoring. Case Presentation: This case study reports presentation 57-year-old man who presented rapidly decompensated stage E was effectively safely treated aggressive intravenous hydration, defined plant-based diet (DPBD), reduction prescription medications without Conclusions: Hydration, DPBD, medication burden may effective Pilot studies warranted evaluate efficacy this intervention larger cohort.

Language: Английский

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Management of Elderly Patients with Chronic Kidney Disease

Yonsei Medical Journal, Journal Year: 2024, Volume and Issue: 66(2), P. 63 - 63

Published: Nov. 8, 2024

Chronic kidney disease (CKD) is highly prevalent among elderly patients, and as the global population ages, number of patients with CKD increasing. Elderly require additional considerations beyond those required for their younger counterparts, such comorbidities, frailty, geriatric syndromes. In this review, we primarily focus on these specific to discuss assessment its management strategies, including blood pressure glycemic control; dyslipidemia, anemia, electrolyte metabolic acidosis management; medication dosage, others, well polypharmacy nonpharmacological management. Furthermore, concept conservative practical recommendations Korean Society Geriatric Nephrology end-stage requiring dialysis therapy are discussed. particular, aging rate in Korea exceptionally high; therefore, it crucial pay more attention increase CKD. A palliative approach, rather than intensive treatment may be necessary patients. a world an abundance information, shared decision-making great importance, essential keep mind that holds true well.

Language: Английский

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Polypharmacy in an Older Female: Thoughtful Deprescribing

Journal of The Indian Academy of Geriatrics, Journal Year: 2024, Volume and Issue: 20(4), P. 219 - 222

Published: Oct. 1, 2024

Abstract The magnitude of polypharmacy is on the rise as global population faces a demographic shift with larger proportion older people, along marked increase in prevalence multimorbidity. An 85-year-old woman diabetes mellitus, systemic hypertension, rheumatoid arthritis, chronic depression, parkinsonism, and dementia presented inappropriate polypharmacy, taking 32 medications. Comprehensive medication reconciliation was performed using Discuss, Review, Use tools, Geriatric medicine approach, Stop guide, assessing appropriateness based Beers Criteria. Goals care were established through shared decision-making, focusing reducing her pill burden relaxing treatment targets for blood pressure glycated hemoglobin. patient ultimately prescribed 13 This case highlights importance tailored, patient-centered approaches managing conditions adults to improve overall health outcomes.

Language: Английский

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