Food Control, Journal Year: 2024, Volume and Issue: 169, P. 111002 - 111002
Published: Nov. 4, 2024
Language: Английский
Journal of Toxicology and Environmental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11
Published: Jan. 26, 2025
Inflammatory bowel disease (IBD) is a complex gastrointestinal disorder attributed to genetic and environmental factors. Microcystin-leucine-arginine (MC-LR) an toxin that accumulates in the gut produces intestinal damage. The aim of this study was investigate effects exposure MC-LR on development progression IBD as well examine underlying mechanisms microcystin-initiated tissue Male C57BL/6 mice were treated with either alone or concurrently dextran-sulfate sodium (DSS). Mice divided into 4 groups (1): PBS gavage (control, CT) (2); 200 μg/kg (3); 3% DSS Drinking Water (DSS); (4) + (DSS MC-LR). each experimental group exhibited reduced body weight, shortened colon length, increased activity index (DAI) score, disrupted barrier, elevated levels proinflammatory cytokines compared control. Compared alone, colitis symptoms exacerbated following combined both MC-LR. Subsequent experiments confirmed protein phosphorylation Janus Kinase1 (JAK1) Signal Transducer Activator Transcription3 (STAT3). treatment also significantly upregulated expression related proteins. In conclusion, our indicates MC-LR-induced involves activation JAK1/STAT3 signaling pathway exacerbates DSS-induced through same pathway.
Language: Английский
Citations
0
PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e18880 - e18880
Published: Feb. 10, 2025
Background Taking into account the global spread of microplastic (MP) pollution, problem MP impact on human health is relevant. enters organism predominantly with water and food, mostly detected in large intestine. Therefore, connection between pollution increase colitis an important question. In order to assess toxic pathogenetic effects MP, experimental studies were actively conducted during recent years, mainly laboratory mice. Objectives The aim our review was summarize systematize data effect mice colon under normal conditions role development intestinal diseases. This manuscript could be relevant for ecologists, biologists, physicians dealing problems related anthropogenic environmental changes inflammatory bowel Survey Methodology search based PubMed about original healthy colitis. Results colon, can cause oxidative stress, increased permeability, immune cell infiltration, production proinflammatory factors, decreased mucus production. affects proliferation, apoptosis, differentiation epithelial cells, expression tight junction components glycocalyx, membrane transport, signaling pathways, metabolome, microflora composition. acute chronic colitis, consumption leads a more pronounced pathological process course. Conclusions may one factors contributing humans. However, further research needed.
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 205, P. 115907 - 115907
Published: Feb. 11, 2025
Language: Английский
Citations
0
Environmental Pollution, Journal Year: 2025, Volume and Issue: 371, P. 125941 - 125941
Published: Feb. 27, 2025
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 292, P. 117967 - 117967
Published: March 1, 2025
Excessive intake of essential and toxic metals affects the pathological process osteoporosis. At present, effects single forms iron (Fe), lead (Pb) other on bone injury have been widely studied. However, these metal elements usually do not exist in environment a separate form. They are ingested various ways often found together human body. mechanism damage caused by Fe Pb mixed exposure is still unclear at this stage. combined analysis multi-omics conventional method to explore molecular behind disease. Therefore, we attempted combine proteomics metabolomics explain exposure. Differential proteins metabolites were be predominantly enriched JAK-STAT signalling pathway, inflammatory bowel disease (IBD), osteoclast differentiation. Combined showed that Fpr2, Lifr, Lisofylline, 7-Ketocholesterol, LacCer (d18: 1/14:0) substances may involved mediated In summary, hypothesise leads activation via pathway situ indirectly gut-bone axis, resulting damage. general, our study potentially suggests induced related proliferation changes levels vivo.
Language: Английский
Citations
0
Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)
Published: March 23, 2025
Language: Английский
Citations
0
IGI Global eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 259 - 292
Published: April 2, 2025
This chapter delves into the complex relationship between nursing practices and environment, aiming to illuminate interconnectedness challenges within this dynamic field. Improved practice environments are pivotal in attaining optimal outcomes for nurses. Healthcare can participate positively or negatively on environmental quality, it contribute cycle of harm through mishandling waste water pollution, preservation environment. Therefore, incorporating practical measures protection hospitals presents a valuable opportunity elevate quality patient care, reducing occurrence illness enhance health. Nurses incorporate sustainability considerations diagnosis treatment. They play crucial role observing effects lifestyles, social vulnerability, pollution heatwaves. hold considerable societal esteem information they provide, influencing behavior towards health
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 17 - 30
Published: Jan. 1, 2025
Language: Английский
Citations
0
FEBS Open Bio, Journal Year: 2024, Volume and Issue: 14(9), P. 1397 - 1419
Published: Sept. 1, 2024
Although the concept of endocrine disruptors first appeared almost 30 years ago, relatively recent involvement these substances in etiology metabolic pathologies (obesity, diabetes, hepatic steatosis, etc.) has given rise to Metabolic Disrupting Chemicals (MDCs). Organs such as liver and adipose tissue have been well studied context disruption by substances. The intestine, however, unexplored despite its close link with organs. In vivo models are useful for study effects MDCs intestine and, addition, allow investigations into interactions rest organism. latter respect, zebrafish is an animal model which used increasingly characterization use a assessing on will, no doubt, expand. This review aims highlight importance metabolism present relevant alternative investigating effect pollutants focusing, particular, cytochrome P450 3A (CYP3A), one major molecular players endogenous gut.
Language: Английский
Citations
3
Genes, Journal Year: 2023, Volume and Issue: 14(7), P. 1455 - 1455
Published: July 16, 2023
Bisphenols are environmental toxins with endocrine disruptor activity, yet bisphenol A (BPA) and its analogs still widely used in manufacturing plastic products. There is evidence showing that BPA elicits inflammation humans animals, but the target cell types of not well understood. In this study, we sought to determine BPA’s direct effect on macrophages immunotoxicity mouse intestine. Ghrelin an important nutrient-sensing hormone, acting through receptor growth hormone secretagogue (GHSR) regulate metabolism inflammation. We found promotes intestinal inflammation, increased infiltrating immune cells colons enhanced expression Ghsr pro-inflammatory cytokines chemokines, such as Il6 Ccl2, colonic mucosa. Moreover, both long- short-term exposure elevated monocytes peripheral blood mononuclear (PBMC) peritoneal (PM), respectively. To role GHSR BPA-mediated generated deletion mutation murine macrophage RAW264.7 using CRISPR gene editing. wild-type cells, polarization increases cytokine/chemokine Ccl2 expression. Interestingly, mutants showed a marked reduction response BPA, suggesting required for BPA-induced response. Further understanding how signaling regulates will help design new strategies mitigate provide policy guidance biosafety.
Language: Английский
Citations
7