Food Control, Journal Year: 2024, Volume and Issue: 169, P. 111002 - 111002
Published: Nov. 4, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 15, 2024
Aplastic anemia (AA) and hypoplastic myelodysplastic syndrome are paradigms of autoimmune hematopoietic failure (AHF). Myelodysplastic acute myeloid leukemia unequivocal neoplasms (MNs). Currently, AA is also known to be a clonal hematological disease. Genetic aberrations typically observed in MNs detected approximately one-third patients. In patients harboring MN-related genetic aberrations, poor response immunosuppressive therapy (IST) an increased risk transformation occurring either naturally or after IST predicted. Approximately 10%-15% with severe transform the disease phenotype following IST, some patients, leukemic emerges during shortly IST. Phenotypic transformations between AHF can occur reciprocally. A fraction advanced MN experience aplastic crisis which blasts repressed. The switch that shapes change strength extramedullary inflammation. Both have immune-active bone marrow (BM) environment (BME). inflamed BME evoked by infiltrated immune cells targeting neoplastic molecules, contributes BM-specific impairment. Autoimmune responses may represent antileukemic mechanism, inflammatory stressors strengthen immunity, at least significant proportion who aberrations. During active episodes, normal hematopoieses suppressed, leads occurrence cytopenia cell regression. successful treatment underlying infections mitigates stress-related activities promotes penetration hematopoiesis. effect similar treating infections. Investigating stress-powered immunity highly important theoretical studies clinical practice, especially given wide application immune-activating agents checkpoint inhibitors neoplasms.
Language: Английский
Citations
2
Microplastics, Journal Year: 2024, Volume and Issue: 3(2), P. 217 - 233
Published: April 8, 2024
The tremendous plastic production and poor post-use management are current future sources of environmental human contamination due to their degradation products: microplastics nanoplastics (MNPLs). Methodological developments have allowed MNPLs be detected in an increasing variety foods, as well stool colonic mucosa. It was suggested early that the direct contact between intestinal tissues could represent a potential risk for health. In order assess this, over last 3 years, numerous studies evaluated impact MNPL ingestion on homeostasis rodents. This comprehensive review reports preclinical published January 2021 2024, analyzes contributions shortcomings. shows evidence is accumulating toxicity spherical MNPLs, which lead pro-inflammatory, pro-oxidative, barrier-disruptive dysbiotic effects. However, available literature has addressed only minor part health issues MNPLs. Many parameters contributing need better taken into account studies. Particular attention should paid improve representativeness consider susceptibility factors toxicity, generated especially by underlying pathology or pathological imprinting.
Language: Английский
Citations
2
Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 9, 2024
Abstract The global burden of Inflammatory bowel disease (IBD) has been rising over the last decades. IBD is an intestinal disorder with a complex and largely unknown etiology. characterized by chronically inflamed gastrointestinal tract, intermittent phases exacerbation remission. This compromised barrier can contribute to, enhance, or even enable toxicity drugs, food-borne chemicals particulate matter. review discusses whether prevalence in our society warrants consideration patients as specific population group toxicological safety assessment. Various vivo, ex vivo vitro models are discussed that simulate hallmarks may be used to study effects prevalent inflammation on hazards these various toxicants. In conclusion, risk assessments based healthy individuals not sufficiently cover patient it suggested consider this susceptible subgroup future assessments.
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 268, P. 115685 - 115685
Published: Nov. 16, 2023
Triphenyl phosphate (TPHP), one widely used organophosphate flame retardant, has attracted accumulating attention due to its high detection rate in human biological samples. Up date, the effects of TPHP exposure on intestinal health remain unexplored. In this study, BALB/c mice were as a model and exposed at dose 2, 10, or 50 mg/kg body weight for 28 days. We observed Crohn's disease-like features ileum ulcerative colitis colon, such shorter colon length, ileum/colon structure impairment, epithelial cell apoptosis, enrichment proinflammatory cytokines immune cells, disruption tight junction. Furthermore, we found that induced production reactive oxygen species apoptosis Caco-2 accompanied by junction between cells. To understand molecular mechanism underlying TPHP-induced changes intestines, build adverse outcome pathway (AOP) framework based Comparative Toxicogenomics GeneCards database. The AOP revealed PI3K/AKT FoxO signaling might be associated with cellular an increase ROS production, increased inflammation response mouse tissues challenged TPHP. These results identified IBD-like provided new perspectives toxicity evaluation
Language: Английский
Citations
6
Food Control, Journal Year: 2024, Volume and Issue: 169, P. 111002 - 111002
Published: Nov. 4, 2024
Language: Английский
Citations
1