The recent development, application, and future prospects of muscle atrophy animal models DOI Creative Commons
Gongchang Zhang,

Fengjuan Hu,

Tingting Huang

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский

Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis DOI Creative Commons
Anna Tylutka, Łukasz Walas, Agnieszka Zembroń-Ƚacny

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 1, 2024

Introduction Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) a risk cardiovascular neurodegenerative diseases also associated with sarcopenia frailties. objective this study was to assess each cytokine: IL-6, TNF, IL-1β separately the elderly comorbidities against controls without according data published available literature. Methods electronic bibliographic PubMed database systematically searched select all relevant studies up July 2023. total number subjects involved meta-analysis included patients ( n =8154) =33967). Results overall concentration IL-6 found be higher compared difference statistically significant, p -value <0.001 (SMD, 0.16; 95% CI, 0.12–0.19). heterogeneity considerable Q = 109.97 (P <0.0001) I 2 79.2%. potential diagnostic usefulness confirmed by odds ratio (OR) analysis (OR: 1.03, CI (1.01; 1.05), =0.0029). both TNF elevated control group amounted SMD -0.03; -0.09–0.02, 0.533 SMD-0.29; -0.47– -0.12; 0.001, respectively. For however, insignificant. Discussion unlike IL-1β, could useful convenient marker peripheral adults various comorbidities.

Language: Английский

Citations

39
The relationship between sarcopenia and metabolic dysfunction-associated fatty liver disease among the young and middle-aged populations DOI Creative Commons

Ziyan Feng,

Fanrong Zhao,

Ziyao Wang

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 15, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing disease, which is considered to be multi-systemic with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young middle-aged adults. Thus, we examined the relationship in individuals this study.

Language: Английский

Citations

7
Sarcopenia's Role in Pre- and Postoperative Inflammation: Implications for CRC Patient Outcomes DOI

Shizhen Zhou,

K. Wang,

Qinggang Yuan

et al.

Journal of Gastrointestinal Surgery, Journal Year: 2024, Volume and Issue: 28(11), P. 1791 - 1798

Published: Aug. 23, 2024

Language: Английский

Citations

5
Exploring the impact of interleukins on sarcopenia development: A systematic review and meta-analysis DOI Creative Commons

Yan He,

Wenrong Duan,

Ping Xu

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 193, P. 112480 - 112480

Published: June 12, 2024

The role of interleukins in sarcopenia development has been acknowledged, yet the specifics their involvement remain to be fully understood. This study aimed explore alterations interleukin levels among patients.

Language: Английский

Citations

4
The Association Between Low Muscle Mass and the Risk of Depressive Symptoms: A Cross‐Sectional Study Based on the Chinese Longitudinal Health Longevity Survey (CLHLS) DOI Creative Commons

Yu‐Ting Yang,

Yan Wang, Qiao Yi Chen

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

ABSTRACT Background Many studies have shown a strong link between sarcopenia and depression, low muscle mass (LMM) is an important component in the diagnosis of sarcopenia; however, there been no on relationship LMM depressive symptoms Chinese elderly population. To estimate potential among older adults, cross‐sectional analysis was conducted utilizing data from Longitudinal Health Longevity Survey (CLHLS). Method The study sample comprised 11,711 individuals aged 65 years or (mean age 83.0 ± 10.9) CLHLS database 2018. We used corrected appendicular skeletal (ASM) prediction formula to assess 10‐item Center for Epidemiological Studies‐Depression Scale (CES‐D‐10) symptoms. A multivariate logistic regression model restricted cubic spline (RCS) curves were employed investigate association Results findings revealed 1.16‐fold higher risk group compared control (adjusted odds ratio [aOR]: 1.16, 95% confidence intervals [95% CI]: 1.05–1.29, p < 0.001). Furthermore, every one‐point decrease score below 7.87, increased by 8%, with statistical significance. However, when greater than equal did not significantly increase Conclusion Our suggests factor population, within certain range, increases as decreases. Physical exercise may be effective strategy maintain optimal help mental health elderly.

Language: Английский

Citations

0
Risk factors and predictive modeling in a US population with sarcopenia: a propensity score cohort study DOI Creative Commons

Yao Sun,

Shuguang Yang,

Zengli Xiao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 26, 2025

Sarcopenia, characterized by loss of muscle mass and strength, particularly affects older adults is linked to increased morbidity mortality. The study aimed investigate the relationship between biomarkers, including hemoglobin (Hb), lactate dehydrogenase (LDH), Systemic Immune-Inflammation Index (SII), sarcopenia in US population. Utilizing NHANES data from 2003 2018, analyzed 5,615 participants, categorizing them based on quartiles Hb, SII, LDH levels. It employed logistic regression models assess these biomarkers risk, adjusting for various confounders. High levels LDH, Hb SII were significantly associated with sarcopenia, higher risk highest quartile. AUC all indicators predicting was 0.925 (sensitivity 0.925; specificity 0.743). concludes that elevated are significant emphasizing role inflammation its development potential markers early detection intervention.

Language: Английский

Citations

0
Impact of Oral Health Interventions on Sarcopenia and Frailty in Older Adults: A Systematic Review DOI Open Access
Andrés Celis, Billy A. Caceres, Beatriz Escobar

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1991 - 1991

Published: March 15, 2025

Background/Objectives: Frailty and sarcopenia are geriatric syndromes associated with increased vulnerability to adverse health outcomes, including functional decline, disability, mortality. Emerging evidence suggests that oral interventions may play a role in mitigating these conditions. This systematic review aims evaluate the impact of on frailty older adults. Methods: A search was conducted PubMed, Scopus, SciELO databases for studies published up December 2023. Inclusion criteria comprised experimental quasi-experimental assessing dental their effects individuals aged 60 years older. The primary outcomes included index, grip strength, walking speed, dentition. Study quality assessed using GRADEpro. Results: Eight were included. Preventive hygiene improved but did not significantly scores. Oral exercises muscle strength weight, leading score reductions (−1.1 points, 95% CI: −1.5 −0.7, p < 0.01). Swallowing therapies linked (+1.8 kg, = 0.03) speed (+0.2 m/s, 0.04), corresponding index (−0.8 −1.2 −0.4, certainty ranged from very low moderate. Conclusions: interventions, particularly swallowing therapies, show potential reducing sarcopenia-related However, methodological heterogeneity low-certainty highlight need high-quality, large-scale trials standardized assessment measures establish definitive clinical recommendations.

Language: Английский

Citations

0
The Potential Role of C4 MYH11+ Fibroblasts and the MDK-SDC2 Ligand-Receptor Pair in Lung Adenocarcinoma: Implications for Prognosis and Therapeutic Strategies DOI

H. Jia,

Yanjie Bian, Jie Yuan

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 55, P. 102364 - 102364

Published: March 22, 2025

Language: Английский

Citations

0
Association of interleukin-6 with sarcopenia and its components in older adults: a systematic review and meta-analysis of cross-sectional studies DOI Creative Commons
Jie Ding, Guangyue Yang,

Wen Sun

et al.

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: Aug. 22, 2024

Background Observational studies have documented increased serum IL-6 levels in elderly individuals afflicted with sarcopenia. Nevertheless, the relationship between concentrations and sarcopenia prevalence aging population is yet to be defined.

Language: Английский

Citations

2
The Association between Sarcopenic Obesity and DXA-Derived Visceral Adipose Tissue (VAT) in Adults DOI Open Access
Antonino De Lorenzo, Leila Itani, Marwan El Ghoch

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1645 - 1645

Published: May 27, 2024

Many people with overweight and obesity are affected by sarcopenia, which is represented a phenotype known as sarcopenic (SO), characterized excessive body fat (BF), combined reduced muscle mass strength. In this population, it vital to identify the factors associated SO. With aim in mind, we investigated association between visceral adipose tissue (VAT) SO patients or nutritional setting. A total of 256 participants (23.8% female) were involved completed composition assessment, including VAT mass, using dual-energy X-ray absorptiometry (DXA). The sample was initially categorized according whether individual had phenotype; they then classified their into three tertiles (lowest, medium, highest). Among participants, who median index (BMI) 29.3 (interquartile range (IQR): 27.0–32.4) kg/m2 age 51.0 (IQR: 47.0–54.0) years, 32.4% identified having SO, displayed higher (517.0 384.5–677.0) vs. 790.0 654.0–1007.0) g; p < 0.05). logistic regression model that accounted for age, sex BMI revealed increases risk (odds ratio (OR) = 1.003; 95% confidence interval (CI): 1.001–1.004; conclusion, appears be an independent factor obesity. However, due cross-sectional design, no information regarding any causality can provided. Additional longitudinal research direction should therefore conducted.

Language: Английский

Citations

2