Abstract
Muscle
atrophy,
characterized
by
the
loss
of
muscle
mass
and
function,
is
a
hallmark
sarcopenia
cachexia,
frequently
associated
with
aging,
malignant
tumors,
chronic
heart
failure,
malnutrition.
Moreover,
it
poses
significant
challenges
to
human
health,
leading
increased
frailty,
reduced
quality
life,
heightened
mortality
risks.
Despite
extensive
research
on
consensus
in
their
assessment
remains
elusive,
inconsistent
conclusions
regarding
molecular
mechanisms.
atrophy
models
are
crucial
tools
for
advancing
this
field.
Currently,
animal
used
clinical
basic
scientific
studies
induced
through
various
methods,
including
genetic
editing,
nutritional
modification,
exercise,
wasting
diseases,
drug
administration.
also
include
vitro
small
organism
models.
value,
each
these
has
certain
limitations.
This
review
focuses
limitations
diverse
applications
understand
encourage
rational
use
future
research,
therefore
deepening
understanding
underlying
pathophysiological
mechanisms,
ultimately
exploration
therapeutic
strategies
cachexia.
Rheumatology Science and Practice,
Journal Year:
2024,
Volume and Issue:
62(5), P. 529 - 534
Published: Nov. 1, 2024
Aim
–
to
evaluate
the
association
among
appendicular
lean
mass
and
immunological
markers
of
blood
serum
in
women
with
rheumatoid
arthritis
(RA).
Material
methods
.
200
RA
(median
age
60.0
[52.5;
65.5]
years)
were
enrolled
study.
Using
dual-energy
X-ray
absorptiometry
(ALM)
was
measured
determine
sarcopenic
phenotype
body
composition.
The
assessment
C-reactive
protein
(CRP),
factor,
antibodies
cyclic
citrullinated
peptide
also
performed.
levels
myostatin,
follistatin,
interleukin
6
(IL-6),
IL-6
receptors,
insulin-like
growth
factor
1
(IGF-1),
adiponectin,
leptin,
fibroblast
23
(FGF23),
tumor
necrosis
SF12
(superfamily
member
12)
studied
87
patients.
Results
According
presence
patients
differed
CRP
(8.6
[1.3;
22.2]
5.6
[1.2;
17.4]
mg/l,
respectively;
p=0.041)
leptin
(3.8
[2.4;
5.7]
5.4
[3.8;
6.9]
ng/ml,
p=0.030).
ALM
correlated
CRP,
follistatin
leptin.
Linear
multivariate
regression
analysis
revealed
between
index
(β=–0.35;
p=0.007),
IGF1
(β=–0.38;
p=0.002),
(β=0.36;
p=0.004)
FGF23
(β=0.33;
p=0.008).
Conclusion
study
showed
that
there
is
an
level
IGF-1,
RA.
Abstract
Muscle
atrophy,
characterized
by
the
loss
of
muscle
mass
and
function,
is
a
hallmark
sarcopenia
cachexia,
frequently
associated
with
aging,
malignant
tumors,
chronic
heart
failure,
malnutrition.
Moreover,
it
poses
significant
challenges
to
human
health,
leading
increased
frailty,
reduced
quality
life,
heightened
mortality
risks.
Despite
extensive
research
on
consensus
in
their
assessment
remains
elusive,
inconsistent
conclusions
regarding
molecular
mechanisms.
atrophy
models
are
crucial
tools
for
advancing
this
field.
Currently,
animal
used
clinical
basic
scientific
studies
induced
through
various
methods,
including
genetic
editing,
nutritional
modification,
exercise,
wasting
diseases,
drug
administration.
also
include
vitro
small
organism
models.
value,
each
these
has
certain
limitations.
This
review
focuses
limitations
diverse
applications
understand
encourage
rational
use
future
research,
therefore
deepening
understanding
underlying
pathophysiological
mechanisms,
ultimately
exploration
therapeutic
strategies
cachexia.
