Trajectories of health conditions and their associations with the risk of cognitive impairment among older adults: insights from a national prospective cohort study

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Background The associations between trajectories of different health conditions and cognitive impairment among older adults were unknown. Our cohort study aimed to investigate the impact various trajectories, including sleep disturbances, depressive symptoms, functional limitations, multimorbidity, on subsequent risk impairment. Methods We conducted a prospective by using eight waves national data from Health Retirement Study (HRS 2002–2018), involving 4319 aged 60 years or in USA. Sleep disturbances symptoms measured Jenkins Scale Centers for Epidemiologic Research Depression (CES-D) scale, respectively. Functional limitations assessed activities daily living (ADLs) instrumental (IADLs), Multimorbidity status was self-reporting physician-diagnosed diseases. identified 8-year at four examinations 2002 2010 latent class trajectory modeling. screened participants 27-point HRS scale 2018 across waves. calculated hazard ratios (HR) Cox proportional models. Results During 25,914 person-years, 1230 developed In fully adjusted model 3, ADLs not associated with Compared low trajectory, we found that increasing (HR = 1.39; 95% CI 1.17–1.65), IADLs 1.88; 1.43–2.46), high multimorbidity 1.48; 1.16–1.88) all posed an elevated higher urban areas 2.30; 1.65–3.21) those who smoked 2.77; 1.91–4.02) (all P interaction < 0.05). Conclusions results suggest tracking functioning may be potential feasible screening method identifying

Language: Английский

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Moderating effect of instrumental activities of daily living on the relationship between loneliness and depression in people with cognitive frailty

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 21, 2025

The identification of depression and loneliness among people with cognitive frailty (CF) could prevent negative psychological physical health outcomes. Few studies have focused on mental together, little is known about the role daily activity in association between elderly individuals CF. To determine positive effect community-dwelling older adults CF as well moderating instrumental activities living (IADL) this association. This cross-sectional study included 529 aged 65 years from a population who were screened for was conducted July 2023 to December 2023. participants assessed via validation instruments following main variables: Short-form Geriatric Depression Scale, Loneliness Questionnaire, Athens Insomnia Instrumental Activities Daily Living (IADL), Social Support sociodemographic characteristics. classified having reversable (RCF) or potentially (PRCF). IADL, depression, insomnia, scores lower RCF than PRCF. IADL shows that relationship has steeper slope when levels exist, compared straight line there are higher case, less steep showed integrity social connections protective It necessary pay attention disability individuals. Targeted interventions improving participation seem be practical feasible solutions alleviate depressive symptoms.

Language: Английский

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Effect of social participation on the trajectories of activities of daily living disability among community-dwelling older adults: a 7-year community-based cohort

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: May 7, 2024

Studies examining the effects of social participation on activities daily living (ADL) disability are still scarce.

Language: Английский

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Trajectories of activities of daily living/ instrumental activities of daily living and the risk of cardiovascular diseases

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 103969 - 103969

Published: March 1, 2025

Language: Английский

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Prevalence of depression and its network structure and association with quality of life in older adults with hypertension: findings of a national survey

Psychogeriatrics, Journal Year: 2025, Volume and Issue: 25(3)

Published: April 20, 2025

Abstract Introduction Based on the Chinese Longitudinal Healthy Longevity Survey (CLHLS), this study aimed to examine prevalence and correlates of depression, its network structure association with quality life (QOL) in older adults hypertension. Methods Depression QOL were measured using 10‐item Center for Epidemiologic Studies Short Scale (CESD‐10) World Health Organization Quality Life‐brief version, respectively. Univariable multivariable analyses performed. Network analysis was used explore interconnections between depressive symptoms. The flow function identify symptoms that directly associated QOL. Results A total 5032 hypertension included. depression (CESD‐10 score ≥ 10) 28.3% (95% confidence interval: 27.08%–29.59%), which significantly poor ( P < 0.001). Participants who male 0.001), resided urban areas = 0.006), lived their family had perceived fair or good economic status higher level instrumental activities daily living 0.001) lower risk depression. In model CESD3 ‘Feeling blue/depressed’, CESD4 ‘Everything an effort’ CESD8 ‘Loneliness’ most central CESD10 ‘Sleep disturbances’ highest negative QOL, followed by CESD5 ‘Hopelessness’, CESD7 ‘Lack happiness’. Conclusion common among To prevent reduce impact population, appropriate interventions should target both

Language: Английский

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Association between impaired cognition status and activities of daily living among elderly: Evidence from longitudinal ageing study in India

Journal of Family Medicine and Primary Care, Journal Year: 2025, Volume and Issue: 14(4), P. 1271 - 1278

Published: April 1, 2025

To determine the association of impaired cognition status with activities daily living among elderly Indian (≥ 60 years) population. Cross-sectional comparative analysis was conducted using nationally representative data from a longitudinal ageing study in India (LASI) survey (2017-18). The univariate and multivariate logistic regression established associations between living. Among subjects, 41.6% 16.3% faced difficulties instrumental significant adjusted odds having ADL difficulty 1.46 times more IADL 2.31 participants than normal. With ageing, worsen which is found our results. Due to rapidly increasing population, early detection prevention disability or preservation functioning for population females particular should be highest priority public health decision-makers.

Language: Английский

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IADL for identifying cognitive impairment in Chinese older adults: insights from cross-lagged panel network analysis

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 22, 2025

As China has entered an aging society, the prevention of cognitive impairment is great importance. The progression usually a slow and continuous process, with Instrumental Activities Daily Living (IADL) serving as sensitive indicator for early prediction decline. objective this study was to utilize longitudinal network analysis pinpoint most indicators IADLs identify in different populations, offer practical recommendations preventing among older adults China. A total 2,781 participants were selected from Chinese Longitudinal Healthy Longevity Survey (CLHLS 2014-2018). Cognitive function assessed by Mini-mental State Examination (MMSE) modified Lawton scale, respectively. In study, cross-lagged panel (CLPN) model employed construct three separate networks all adults, male female Two centrality indices used quantify symptom directed CLPN: In-Expected-Influence (IEI) Out-Expected-Influence (OEI). networks, "Use public transit," "Make food" "Walk 1 km" emerged influential important indicators. edge transit → Attention Calculation" strongest connection networks. Among adult males, "General ability" exhibited influence on other domains, followed "Language," while "Attention had weaker influence. Conversely, females, factor, "Language." This provides new insights into associations between specific IADL activities domains adults. Concentrate monitoring limitations related km," promoting broader life-space mobility may be beneficial decline function. findings underscore importance targeting interventions not only but also potentially gender. Not applicable.

Language: Английский

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Identifying Predictive Risk Factors for Future Cognitive Impairment Among Chinese Older Adults: Longitudinal Prediction Study

JMIR Aging, Journal Year: 2024, Volume and Issue: 7, P. e53240 - e53240

Published: March 22, 2024

Abstract Background The societal burden of cognitive impairment in China has prompted researchers to develop clinical prediction models aimed at making risk assessments that enable preventative interventions. However, it is unclear what types factors best predict future impairment, if known make equally accurate predictions across different socioeconomic groups, and existing are subpopulations. Objective This paper identify which domain health information predicts among Chinese older adults examine discrepancies exist predictive ability population subsets. Methods Using data from the Longitudinal Healthy Longevity Survey, we quantified demographics, instrumental activities daily living, tests, social hobbies, psychological factors, diet, exercise sleep, chronic diseases, 3 recently published logistic regression–based 3-year general male, female, rural-dwelling, urban-dwelling, educated, not formally educated adults. Predictive was using area under receiver operating characteristic curve (AUC) sensitivity-specificity curves through 20 repeats 10-fold cross-validation. Results A total 4047 participants were included study, 337 (8.3%) developed years after baseline collection. factor groups with demographics (AUC 0.78, 95% CI 0.77-0.78), tests 0.72, 0.72-0.73), living 0.71, 0.70-0.71). Demographics, all recreated had significantly higher AUCs when female compared male no formal education those some education. Conclusions study suggests most useful for predicting have lower power More efforts needed ensure can be conducted China.

Language: Английский

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Decoding Behavior: Utilizing Virtual Reality Digital Marker and Machine Learning for Early Detection of Mild Cognitive Impairment

Published: May 11, 2024

The imperative for early mild cognitive impairment (MCI) detection is underscored by the limitations of traditional biomarkers, high cost and invasiveness, they often fail to capture behavioral changes in MCI patients associated with impaired instrumental activities daily living (IADL). This study introduces a cost-effective, non-invasive alternative using digital markers, "virtual kiosk test", which involves performing IADL tasks such as ordering food via virtual reality (VR) detect at an stage. Involving 20 healthy controls 31 patients, four key features within VR markers effectively differentiate groups: hand movement speed, proportion fixation duration, time completion, number errors. A machine learning model demonstrated effectiveness 93.3% accuracy, 100% sensitivity, 83.3% specificity, 90% precision, 94.7% F1-score group differentiation. Findings suggest that observing behaviors test 5 minutes can be efficient approach detection, acting reliable markers.

Language: Английский

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Aging trajectories of subscales in higher-level functional capacity among community-dwelling older Japanese adults: the Otassha study

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: June 21, 2024

Maintaining higher-level functional capacity is important for independent living in older age. The aging trajectory of the Tokyo Metropolitan Institute Gerontology Index Competence (TMIG-IC) has three patterns; however, subscale patterns are unclear. This study aimed to clarify TMIG-IC subscales among community-dwelling Japanese. Participants were 3,169 Japanese who participated 2012-2022 mail survey Otassha study. total and scores those aged 65-90 years identified using group-based modeling. Further, combination frequency was determined. Three identified: early-onset decreasing, late-onset high-stable. instrumental activities daily (IADL) maintained until approximately 80 age; chronic disease prevailed most decreasing pattern. pattern intellectual activity (IA) present 25% participants, showing impaired IA from 65 social roles (SR) 30% a sharp decline compared other subscales. For many people, decrease SR overlapped. To maintain capacity, interventions that include management prevention IADL increase awareness support provided throughout old age people with an early should be implemented.

Language: Английский

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