Genomic Profiling and Spatial SEIR Modeling of COVID-19 Transmission in Western New York DOI Creative Commons
Jonathan Bard, Na Jiang,

Jamaal Emerson

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 4, 2023

Abstract The COVID-19 pandemic has prompted an unprecedented global effort to understand and mitigate the spread of SARS-CoV-2 virus. In this study, we present a comprehensive analysis in Western New York, integrating individual patient-level genomic sequencing data with spatially informed agent-based disease Susceptible-Exposed-Infectious-Removed (SEIR) computational model. integration spatial enables multi-faceted exploration factors influencing transmission patterns COVID-19, including population density, movement dynamics, genetic variations viral genomes replicating York State (NYS). Our findings shed light on local dynamics pandemic, revealing potential hotspots transmission. Additionally, provides insights into heterogeneity within single lineage at region-specific level. This interdisciplinary approach, bridging genomics modeling, contributes more holistic understanding dynamics. results study have implications for future public health strategies, guiding targeted interventions resource allocation effectively control similar viruses region.

Language: Английский

Healthcare management in a post-pandemic world: Lessons learned and future preparedness: A review DOI Creative Commons

Oluwaseyi Rita Owolabi,

Funmilola Olatundun Olatoye,

Oluwafunmi Adijat Elufioye

et al.

International Journal of Science and Research Archive, Journal Year: 2024, Volume and Issue: 11(1), P. 1843 - 1852

Published: Feb. 18, 2024

This review paper examines the profound impacts of COVID-19 pandemic on healthcare management, highlighting lessons learned and proposing strategies for future preparedness. It explores immediate challenges systems face, such as resource allocation staff shortages. discusses rapid adaptations innovations that emerged, including expansion telehealth digital health technologies. The also reviews policy management adjustments. applies theoretical frameworks like organizational change, crisis resilience to understand these changes. Key findings emphasize importance resilience, flexibility, innovation in management. Recommendations practice focus enhancing public infrastructure, investing health, fostering international cooperation. concludes with directions research, evaluation interventions address disparities, underscoring need a robust, adaptive, equitable system post-pandemic world.

Language: Английский

Citations

12
HEALTHCARE MANAGEMENT IN A POST-PANDEMIC WORLD: LESSONS LEARNED AND FUTURE PREPAREDNESS - A REVIEW DOI Creative Commons

Toritsemogba Tosanbami Omaghomi,

Opeoluwa Akomolafe,

Jane Osareme Ogugua

et al.

International Medical Science Research Journal, Journal Year: 2024, Volume and Issue: 4(2), P. 210 - 223

Published: Feb. 24, 2024

This review paper examines the profound impacts of COVID-19 pandemic on healthcare management, highlighting lessons learned and proposing strategies for future preparedness. It explores immediate challenges systems face, such as resource allocation staff shortages. discusses rapid adaptations innovations that emerged, including expansion telehealth digital health technologies. The also reviews policy management adjustments. applies theoretical frameworks like organizational change, crisis resilience to understand these changes. Key findings emphasize importance resilience, flexibility, innovation in management. Recommendations practice focus enhancing public infrastructure, investing health, fostering international cooperation. concludes with directions research, evaluation interventions address disparities, underscoring need a robust, adaptive, equitable system post-pandemic world. Keywords: Covid-19 Pandemic, Healthcare Management, Digital Health Technologies, Crisis Management Theory, System Resilience.

Language: Английский

Citations

6
Comprehensive genomic analysis of the SARS-CoV-2 Omicron variant BA.2.76 in Jining City, China, 2022 DOI Creative Commons
Qiang Yin, Wei Liu,

Yajuan Jiang

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: April 17, 2024

Abstract Objective This study aims to analyze the molecular characteristics of novel coronavirus (SARS-CoV-2) Omicron variant BA.2.76 in Jining City, China. Methods Whole-genome sequencing was performed on 87 cases SARS-CoV-2 infection. Evolutionary trees were constructed using bioinformatics software sequence homology, sites, N-glycosylation and phosphorylation sites. Results All whole-genome sequences classified under evolutionary branch BA.2.76. Their similarity reference strain Wuhan-Hu-1 ranged from 99.72 99.74%. In comparison Wuhan-Hu-1, exhibited 77–84 nucleotide differences 27 deletions. A total 69 amino acid 9 deletions, 1 stop codon mutation identified across 18 proteins. Among them, spike (S) protein highest number ORF8 showed a Q27 mutation. Multiple proteins displayed variations glycosylation Conclusion continues evolve, giving rise new strains with enhanced transmission, stronger immune evasion capabilities, reduced pathogenicity. The application high-throughput technologies epidemic prevention control COVID-19 provides crucial insights into virus at genomic level, thereby holding significant implications for pandemic.

Language: Английский

Citations

5
Assessment of repurposed compounds against coronaviruses highlights the antiviral broad-spectrum activity of host-targeting iminosugars and confirms the activity of potent directly acting antivirals DOI Creative Commons
Juliane Brun, Edi Dharmana, Michelle L. Hill

et al.

Antiviral Research, Journal Year: 2025, Volume and Issue: unknown, P. 106123 - 106123

Published: Feb. 1, 2025

Language: Английский

Citations

0
Characteristics and Outcomes of Children Hospitalized With COVID-19 During Early Pandemic and Delta Variant DOI

L Denise Willis,

Beverly J. Spray,

Erin Henderson

et al.

Respiratory Care, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Background: Children were less affected by severe illness as compared to adults at the start of COVID-19 pandemic. As pandemic progressed and variants emerged, pediatric hospitalizations increased, some previously healthy children developed multisystem inflammatory disorder. The aim this study was describe characteristics outcomes hospitalized with from beginning through Δ variant. Methods: Data collected retrospectively for during March 2020-November 2021 a diagnosis COVID-19. Admissions classified early or delta variant, between time periods. Primary outcome measures hospital length stay use respiratory support. number admissions/month secondary outcome. Results: There 784 admissions: 400 378 period. Forty-four percent had an underlying medical condition, 78% not eligible vaccination. Oxygen most common support modality required more often (P < .001). Hospital longer period .001), monthly admissions higher. A statistically significant but low correlation identified body mass index (BMI) Z score .001, r = 0.19). Conclusions: variant associated increased preexisting conditions likely require have hospitalization than others. Higher BMI also weakly stay. reason admission attributed causes other majority except

Language: Английский

Citations

0
Alignment Between Treatment Decision and Treatment Administration for Squamous Cell Carcinoma of the Upper Aerodigestive Tract Before, During, and After the COVID-19 Pandemic: A Retrospective Analysis DOI Open Access
Benjamin Reliquet, Thomas Thibault, Paul Elhomsy

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2613 - 2613

Published: April 10, 2025

Objective: The aim of this study was to assess the impact COVID-19 pandemic on adequacy between treatment decisions made in multidisciplinary team meetings (MTMs) and therapy administered patients with upper aerodigestive tract cancers. Secondary aims included assessing administration times at different periods identifying factors explaining discrepancies. Methods: A retrospective, monocentric conducted a university hospital center from 2019 2021, including 475 first-line patients. Patients were divided into two groups: those matching treatments (MTMs vs. delivered) Alignment decision delivery compared among three (before, during, after pandemic), influencing non-alignment analyzed using univariate multivariate analysis. Results: Of patients, 106 (23%) received differing MTM decisions. period saw more advanced cancers (4.8% metastatic 12% 2020), poorer general condition, undernutrition. did not significantly affect (p = 0.4). Factors linked mismatches worse condition (PS ≥ 2, p < 0.001) locally tumors (T3/4, 0.002). Shorter processing noted during post-pandemic periods. Conclusions: Despite treated had continuous care similar alignment as before. This shows effectiveness ongoing pandemic, ensuring adherence.

Language: Английский

Citations

0
Precision epidemiology at the nexus of mathematics and nanotechnology: Unraveling the dance of viral dynamics DOI
Alaa A. A. Aljabali, Mohammad A. Obeid, Mohamed El‐Tanani

et al.

Gene, Journal Year: 2024, Volume and Issue: 905, P. 148174 - 148174

Published: Jan. 18, 2024

Language: Английский

Citations

2
Unveiling the Effects of the COVID-19 Pandemic on Lung Cancer Surgery DOI Creative Commons
Gabriel Cozma, Călin Muntean,

Alaviana Monique Faur

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(6), P. 964 - 964

Published: June 11, 2024

The aim of this study is to investigate the impact COVID-19 pandemic on surgical treatment lung cancer patients. Data from patients who underwent surgery during were analyzed and compared pre-pandemic post-pandemic periods. Multiple parameters examined, their changes yielded significant results other periods study. statistical analysis revealed a decrease in number interventions (

Language: Английский

Citations

2
Positive mental health, depression and burnout in healthcare workers during the second wave of COVID‐19 pandemic DOI Creative Commons
Chiara Ruini, Giorgio Li Pira,

E. Cordella

et al.

Journal of Psychiatric and Mental Health Nursing, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

Accessible Summary What is known on the subject? In past 2 years, COVID‐19 pandemic had a robust negative impact mental health of healthcare providers, with increasing rates depression, anxiety, acute stress and burnout. Healthcare workers experiencing poor are reluctant to seek help treatment because they afraid being stigmatized excluded by their colleagues employers. During positive emotions, resilience psychological well‐being buffered distress burnout in workers. this paper adds existing knowledge? This describes health, anxiety during second wave pandemic. Forty‐eight per cent were flourishing (high levels emotions well‐being), 10% languishing (absence positivity). Flourishing individuals reported lower These findings documented relevant number resilient workers, who restored/maintained also under stressful conditions. Vulnerable less than 20%, severe depression No differences emerged between moderate groups implications for practice? The condition only one that provides protection from burnout, while does not differ substantially state. study confirms importance maintaining and/or promoting Interventions vulnerable needed. Mental nurses can have skills expertise evaluating early symptoms implementing interventions restoring well‐being. may include informational campaign (i.e. preparing distributing pamphlets guidelines) emotional support programmes (psychoeducation training, team, peer counselling) be delivered via digital platforms. Abstract Introduction Few studies focused workers' high well‐being) its association Aims To evaluate protective role buffering distress. Methods We evaluated 173 Italian indicators (Depression Anxiety Stress Scales [DASS]‐21), (Copenhagen Burnout Inventory [CBI]) (Mental Health Continuum) we cross‐classified them according (flourishing, health) Results classified as flourishing, 42% health. presented scores DASS CBI scales, whereas no groups. More 80% clinically significant risk flourishing. Discussion investigation presence almost half sample However, those or manifested higher risks Implication Practice population, crucial easily approach other provide (training, (psychoeducation, when facing adverse working

Language: Английский

Citations

2
Baricitinib and Pulse Steroids Combination Treatment in Hyperinflammatory COVID-19: A Rheumatological Approach in the Intensive Care Unit DOI Creative Commons
Francesco Ferro, Gaetano La Rocca, Elena Elefante

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7273 - 7273

Published: July 2, 2024

Hyperinflammatory Coronavirus disease 2019 (COVID-19) and rapidly-progressive interstitial lung diseases (RP-ILD) secondary to inflammatory myopathies (IIM) present important similarities. These data support the use of anti-rheumatic drugs for treatment COVID-19. The aim this study was compare efficacy combining baricitinib pulse steroids with Standard Care (SoC) critically ill COVID-19 patients. We retrospectively enrolled consecutive patients admitted Intensive Unit (ICU) COVID-19-pneumonia. Patients treated SoC (dexamethasone plus remdesivir) were compared 6-methylprednisolone pulses (Rheuma-group). 246 patients: 104/246 in 142/246 Rheuma-group. All presented laboratory findings suggestive hyperinflammatory response. Sixty-four (26.1%) died during ICU hospitalization. mortality rate Rheuma-group significantly lower than SoC-group (15.5 vs. 40.4%, p < 0.001). Compared SoC-group, biomarker levels after one week treatment. Higher ferritin strongly associated (p In large real-life cohort, led a significant reduction mortality, paralleled by prompt biomarkers. Our experience supports similarities between IIM-associated RP-ILD.

Language: Английский

Citations

1