Impact of climate change on vaccine responses and inequity

Nature Climate Change, Journal Year: 2024, Volume and Issue: 14(12), P. 1216 - 1218

Published: Nov. 15, 2024

Language: Английский

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Analysis report on trends in public infectious disease control in China

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 7, 2025

The prevention and control of public infectious diseases is a significant issue in the global health sector. Controlling crucial for maintaining health. As most populous country world, China still faces series new challenges diseases. Therefore, it great significance to conduct an in-depth analysis trends This study selects death rate, incidence proportion funds input, professional technical personnel from 2018 2023 as research samples conducts statistical through multiple linear regression. Overall, factors such can explain 98.7% trend changes disease rate. Through regression analysis, coefficient value 0.001 rate indicates positive impact on mortality meaning that increase leads rise mortality. -0.012 funding input suggests negative implying increased investment will correspondingly reduce On other hand, merely increasing number not sufficient spread diseases; comprehensive use various measures required effective control. Public complex process requires consideration factors, rather than changing single factor, particularly controlling rates reasonably allocating funds. By refining strategies integrating diverse preventive intervention measures, possible better diseases, thereby protecting safety.

Language: Английский

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Impact of Climate Change on the Global Dynamics of Vector-Borne Infectious Diseases: A Narrative Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Climate change has significantly altered the dynamics of vector-borne infectious diseases, favoring their proliferation and geographic expansion. Factors such as rising temperatures, frequency extreme weather events, uncontrolled urbanization have increased incidence diseases dengue, Zika, chikungunya, malaria, Lyme disease, especially in vulnerable regions with limited infrastructure. This article presents a narrative review based on recent scientific literature (2018-2025) to assess impact climate vector distribution, co-infections, control strategies. The evidence collected highlights how changing conditions, combined socioeconomic, political, demographic factors, exacerbate public health crises complicate mitigation efforts. It is concluded that facing this challenge requires comprehensive strategy combines environmental management, technological innovation, epidemiological surveillance, community educational programs, promoting coordinated global response reduce associated risks.

Language: Английский

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The Roles of Various Immune Cell Populations in Immune Response against Helminths

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 420 - 420

Published: Dec. 28, 2023

Helminths are multicellular parasites that a substantial problem for both human and veterinary medicine. According to estimates, 1.5 billion people suffer from their infection, resulting in decreased life quality burdens healthcare systems. On the other hand, these infections may alleviate autoimmune diseases allergy symptoms. The immune system is programmed combat infections; nevertheless, its effector mechanisms result immunopathologies exacerbate clinical This review summarizes role of response against worms, with an emphasis on Th2 response, which hallmark helminth infections. We characterize non-immune cells (enteric tuft cells—ETCs) responsible detecting parasites, as well hematopoietic-derived (macrophages, basophils, eosinophils, neutrophils, innate lymphoid group 2—ILC2s, mast cells, T B cells) initiating sustaining functions they play granulomas. aim this paper existing knowledge regarding helminths, attempt decipher interactions between engaged indicate gaps current knowledge.

Language: Английский

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STIKO-Impfempfehlungen 2024

CME, Journal Year: 2024, Volume and Issue: 21(5), P. 49 - 58

Published: May 1, 2024

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Later Sunsets and Vaccination

Published: Jan. 1, 2024

Language: Английский

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Genomic Analysis of Human-infecting Leptospira borgpetersenii isolates in Sri Lanka expanded PF07598 gene family repertoire, less overall genome reduction than bovine isolates

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Leptospira borgpetersenii commonly causes human leptospirosis, including severe disease. The first published analysis of L. , performed on two strains serovar Hardjo (L550 and JB197), concluded that the genome is in process decay with functional consequences leading to a more obligately host-dependent life cycle. Yet whole has only been carried out few limited closed genomes comprehensive analysis. Herein we report complete, circularized seven non-Hardjo isolates from leptospirosis patients Sri Lanka. These (all ST144) were found be nearly identical by analysis; serotyping showed they are novel serovar. We show isolated humans Lanka less genomically decayed than previously reported isolates: fewer pseudogenes (N=141) Insertion Sequence (IS) elements (N=46) compared N=248, N=270, N=400 pseudogenes, N=121 N=116 IS (L550, JB197 TC112). Compared analyses showing three VM proteins cattle, rats humans, all Lanka, Piyasena, have 4 encoded proteins, one ortholog interrogans Copenhageni LIC12339 3 orthologs LIC12844. Our findings expansion LIC12844 homologs PF07598 family these suggests this newly identified unique pathogenicity. Comparative experimental studies will enable deeper insights into molecular cellular mechanisms pathogenesis. Author Summary Leptospirosis an emerging bacterial zoonosis worldwide. predominates as cause some agricultural contexts. address here relatively neglected comparative . reduction available cattle virulence characteristics other animals rats.

Language: Английский

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