GeroScience, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Resveratrol (RES), a natural polyphenolic compound, has garnered significant attention for its therapeutic potential in various pathological conditions. This review explores how RES modulates mitophagy-the selective autophagic degradation of mitochondria essential maintaining cellular homeostasis. promotes the initiation and execution mitophagy by enhancing PINK1/Parkin-mediated mitochondrial clearance, reducing reactive oxygen species production, mitigating apoptosis, thereby preserving integrity. Additionally, regulates through activation key molecular targets such as AMP-activated protein kinase (AMPK), mechanistic target rapamycin (mTOR), deacetylases (SIRT1 SIRT3), quality control (MQC) pathways, demonstrating substantial effects multiple disease models. We provide detailed account biosynthetic pharmacokinetics, metabolic characteristics RES, focusing on role modulation implications medical applications. Potential adverse associated with clinical use are also discussed. Despite promising properties, application is limited issues bioavailability pharmacokinetic profiles. Future research should concentrate developing derivatives that precisely modulate mitophagy, unlocking new avenues therapy.
Language: Английский
Citations
3
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: July 1, 2024
Abstract Background Diabetic wounds present significant challenges, specifically in terms of bacterial infection and delayed healing. Therefore, it is crucial to address local issues promote accelerated wound In this investigation, we utilized electrospinning fabricate microgel/nanofiber membranes encapsulating MXene-encapsulated microgels chitosan/gelatin polymers. Results The film dressing facilitates programmed photothermal therapy (PPT) mild (MPTT) under near-infrared (NIR), showcasing swift extensive antibacterial biofilm-disrupting capabilities. PPT effect achieves prompt sterilization within 5 min at 52 °C disperses mature biofilm 10 min. Concurrently, by adjusting the NIR power induce heating (42 °C), stimulates fibroblast proliferation migration, significantly enhancing vascularization. Moreover, vivo experimentation successfully validates dressing, underscoring its immense potential addressing intricacies diabetic wounds. Conclusions MXene microgel-loaded nanofiber employs temperature-coordinated therapy, effectively amalgamating advantageous features high-temperature low-temperature promotion It exhibits rapid, broad-spectrum capabilities, exceptional biocompatibility, noteworthy effects on promoting cell These results affirm efficacy our highlighting challenge struggling heal due infection. Graphical
Language: Английский
Citations
12
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(4), P. 103921 - 103921
Published: Feb. 20, 2024
Language: Английский
Citations
8
Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 19, 2025
This study examines the relationship between body mass index (BMI) and physical activity levels in e-sports players. Focusing on sedentary lifestyle health risks associated with prolonged sitting low activity, highlights critical challenges within community. Data was collected from 136 players popular gaming platforms such as FIFA, Valorant, CS: GO League of Legends. Physical were assessed using International Activity Questionnaire (Short Form) participants' status BMI classifications. The results showed a significant inverse obese having significantly lower longer periods behavior than their peers. Male had higher females, reflecting biological, social cultural factors that influence behavior. need for measures training programs, ergonomic adjustments awareness campaigns to increase reduce among These findings provide valuable insights into effects participation emphasize importance promoting an active counteract detrimental inactivity. By filling gaps existing literature, this contributes understanding players' behaviors offers practical recommendations healthier habits growing population.
Language: Английский
Citations
1
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: March 13, 2025
Abstract Metabolic diseases, including obesity, diabetes, and metabolic‐associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed complex interplay between these metabolic disorders interferon (IFN) immune responses. As key regulators, interferons coordinate the host's defense against viral infections essential for maintaining homeostasis. However, dysregulation can significantly disrupt IFN signaling pathways, affecting intensity efficiency of Conversely, alterations in influence onset progression diseases. This review explores mechanisms by which diseases modulate responses, focusing on how MAFLD alter signaling. Additionally, we examine implications changes responses By synthesizing current research, this aims to elucidate offering insights future clinical applications field IFN‐related
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(23), P. 7399 - 7399
Published: Nov. 29, 2023
Bone fragility is a complication of type 2 diabetes mellitus (T2DM) that has been identified in recent decades. Trabecular bone score (TBS) appears to be more accurate than mineral density (BMD) diabetic disease, particularly menopausal women with T2DM, independently capture the fracture risk. Our purpose was provide most overview on TBS-associated clinical data T2DM. The core this narrative review based original studies (PubMed-indexed journals, full-length, English articles). sample-based analysis (n = 11, N 4653) confirmed use TBS T2DM females (females/males ratio 1.9), ages varying between 35 and 91 (mean 65.34) years. With concern study design, apart from transversal studies, two others were prospective, while another case-control. These early-post-pandemic included various sample sizes, such as: males (N 245, 361, 511, 2294), only 80, 96, 104, 243, 493, 887), men 169). Overall, 21-month published prior profile BMD-TBS issue whether checking risk mandatory adults uncontrolled remains proven or whether, other hand, reduced might function as surrogate marker complicated/uncontrolled interventional approach bisphosphonates for treating T2DM-associated osteoporosis standard one 2). One control 4 mg zoledronic acid showed after 1 year statistically significant increase lumbar BMD both non-diabetic groups (+3.6%, p 0.01 +6.2%, 0.01, respectively). Further will pinpoint additive benefits glucose status anti-osteoporotic drugs confirm if certain glucose-lowering regimes are supplementarily beneficial reduction. novelty literature research: these insights once again patients often have lower those without normal levels. Therefore, decline may reflect an early stage health impairment handy, non-invasive method proved index microarchitecture confirms its practicality easily applicable tool assessing
Language: Английский
Citations
14
Biology of Reproduction, Journal Year: 2024, Volume and Issue: unknown
Published: June 12, 2024
Abstract Melatonin is a pineal hormone that regulates testicular activity (i.e., steroidogenesis and spermatogenesis) through two complementary mechanisms, indirect effects exerted via the hypothalamic–adenohypophyseal axis direct actions take place on different cell populations of male gonad. The increased age testis general mechanisms involved in pathology leading to infertility are still only poorly understood. However, there growing evidence link aging idiopathic local inflammatory oxidative stress events. Because literature data strongly indicate melatonin exhibits anti-inflammatory anti-oxidant properties, this review focuses potential benefits by indoleamine at level reproductive fertility aging. Taking into account supplementation function currently being investigated, overview covers not promising prospects but also many questions concerning future therapeutic value as an anti-aging drug well management cases for which no medical treatments available.
Language: Английский
Citations
5
BioMolecular Concepts, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 1, 2024
Abstract Among civilization diseases, the number of individuals suffering from type 2 diabetes (T2DM) is expected to increase more than a billion in less 20 years, which associated with, e.g., populational aging, poor diet, sedentary lifestyle, genetic predispositions, and immunological factors. T2DM affects many organs characterized by insulin resistance, high glucose levels, adipocyte dysfunction, are related senescence. Although this cellular aging has beneficial biological functions, it can also act unfavorable since senescent adipocytes resist apoptosis, enhance cytokine secretion, downregulate cell identity genes, acquire senescence-associated secretory phenotype that renders oxidative environment. Opposing possible via wide variety senotherapies, including senolytics senomorphics; nevertheless, further research advised expand therapeutic possibilities benefits. Consequences ought be deeply researched include phenotype, chronic inflammation, increasing as well impairment adipogenesis functioning cells. Herein, despite reviewing fat tissue senescence, we summarized latest adipocyte-related anti-diabetes solutions suggested directions.
Language: Английский
Citations
4
Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(11)
Published: Nov. 1, 2024
Abstract Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart hyperlipidemia. While alterations bacteria are well‐documented, emerging evidence suggests that changes viruses also contribute to these disorders. Bacteriophages, most abundant viruses, influence bacterial populations through their lytic lysogenic cycles, potentially modulating ecosystem pathways. Phage therapy, previously overshadowed by antibiotics, is experiencing renewed interest due rising antibiotic resistance. It offers a novel approach precisely edit microbiota, with promising applications diseases. In this review, we summarize recent discoveries about virome disease patients, review preclinical clinical studies phage therapy on diseases well breakthroughs currently faced problems concerns. image
Language: Английский
Citations
4
Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41734 - e41734
Published: Jan. 1, 2025
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that significantly heighten the risk non-communicable diseases, affecting quality life (QOL) millions, including elderly. Hence, study aims to assess prevalence MetS and its impact on QOL among elderly population, with focus gender differences. A cross-sectional was conducted involving 400 participants sought care at Noakhali General Hospital, Noakhali, Bangladesh. diagnosed based National Cholesterol Education Program's (NCEP) Adult Treatment Panel (ATP) III criteria, while assessed using brief version World Health Organization's (WHOQOL-BREF) tool. Results revealed over 70 % had MetS, higher females (79.2 %) compared males (66.7 %). Gender disparities were also evident in scores, reporting better outcomes across all domains-physical, psychological, social, environmental. Multiple linear regression analysis indicated negatively impacted overall for both genders, more pronounced effects observed females. The findings underscore necessity gender-specific interventions targeting management improve well-being
Language: Английский
Citations
0