A long-acting prolactin to combat lactation insufficiency DOI Creative Commons
Kasia M. Kready, Kailyn E. Doiron,

Katherine Redfield Chan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

Abstract Human infants are born to breastfeed. While 50% of lactating persons struggle make enough milk, there no governmentally-approved drugs enhance lactation 1 . Here, we engineer a variant the naturally-occurring driver lactation, hormone Prolactin, increase its serum half-life and produce viable drug candidate. Our engineered variant, Prolactin-eXtra Long-acting (Prolactin-XL), is comprised endogenously active human prolactin fused an IgG Fc domain designed overcome unique development challenges specific person-infant dyad. Prolactin-XL has 70.9h in mice, 2,625-fold longer than alone (70.9h v. 0.027h). We demonstrate that increases milk production restores growth pups fed by dams with pharmacologically-ablated lactation. show Prolactin-XL-enhanced accompanied reversible, lactocyte-driven changes mammary gland morphology. This work establishes long-acting prolactins as potentially powerful pharmacologic means combat insufficient

Language: Английский

Complex intertwined association between breastfeeding practices and household food insecurity: Systematic review and meta‐analysis DOI Creative Commons
Gabriela Buccini,

Cali Larrison,

Smriti Neupane

et al.

Maternal and Child Nutrition, Journal Year: 2024, Volume and Issue: 20(4)

Published: July 3, 2024

Abstract Breastfeeding offers ideal food and nutrition for infants; however, structural barriers may amplify breastfeeding inequities. We aimed to identify whether household insecurity (HFI) is associated with exclusive continued (EBF CBF) as recommended by the World Health Organization/United Nations Children's Fund (UNICEF) Following Preferred Reporting Items Systematic Reviews Meta‐Analysis, literature searches using ‘breastfeeding’, ‘food insecurity’ ‘infant’ terms were conducted in PubMed/MEDLINE, Embase, CINAHL, Global LILACS from inception through November 2023, without language restrictions, yielding 1382 publications (PROSPERO:CRD42022329836). Predetermined eligibility criteria yielded 12 included studies (nine cross‐sectional three cohorts). The risk of bias was assessed Effective Public Practice Project. Meta‐analysis performed assessing EBF ( n = 10), metaregression used explore heterogeneity across studies. Prevalence ranged 1.6% 85.3%, a lower prevalence among HFI. pooled effect association between HFI presented an odds ratio (OR) 0.61 (95% CI 0.49–0.76) consistent results marginal (OR 0.72, 95% 0.55–0.94), moderate 0.59, 0.41–0.84) severe 0.49, 0.32–0.76). High found only when dichotomized. CBF 35.4% 78.0%, inconsistent HFI; meta‐analysis not due low number 3). concluded that levels are EBF. Integrating service policy‐level strategies, such screening, referrals, skilled counseling access comprehensive social programs, could reduce inequities promote adherence Organization/UNICEF recommendations food‐insecure families.

Language: Английский

Citations

5

Trends and determinants of exclusive and predominant breastfeeding practices for two decades (2000–2019) in Ethiopia DOI Creative Commons
Hailemariam Mamo Hassen

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 22, 2025

Background Ethiopia has had a long-standing national commitment to improving child health. However, evidence on trends in breastfeeding remained fragmented, and there is paucity of information the impacts policy breast feeding practices associated factors influencing it. This study examined determinants exclusive predominant last two decades. Methods The employed retrospective observational design using Ethiopian Demographic Health Surveys (EDHS2000-2019) dataset for children aged <6 months their mothers. Data analyses were performed via SPSS version 25. Trend analysis multivariable logistic regression used. Results Exclusive have fluctuated inconsistently over past increased from 59.96% 2000 66.01% 2016 then decreased 59.86% 2019. Predominant 40.04% 32.95% 39.43% Regional state, place residence, religion significantly ( p < 0.001) with likelihood practicing or breastfeeding. Conclusion These inconsistent complex interplay various suggest limited success previous policies strategies highlight need further investigation revisiting current more nuanced targeted approach future interventions.

Language: Английский

Citations

0

High wet-bulb temperatures, time allocation, and diurnal patterns of breastfeeding in Bangladeshi fisher-traders DOI Creative Commons
Kathrine Starkweather, Haley B. Ragsdale, Margaret Butler

et al.

Annals of Human Biology, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 24, 2025

Climate change is a growing threat to population health, with dangerous combinations of heat and humidity increasing in frequency, particularly South Asia. Evidence suggests that high temperatures stress influence breastfeeding behaviour may lead suboptimal infant young child nutrition. Few studies have quantified the relationship between ambient breastfeeding. Here we evaluate associations wet-bulb temperature daily patterns rural community Bangladesh. We used 23 months time-diary data from 68 maternal-child dyads regional test hypothesis increased negatively outcomes among Shodagor fisher-traders. found higher predicted reduced time allocation, fishers, drove shifts towards night-time decreased mid/late morning feeding. Maternal occupation interaction age strongly influenced diurnal patterns. These results highlight an important role maternal work on infants' vulnerability environmental stress. Dyads' ability behaviourally compensate for extreme be constrained by extended heatwaves, humidity, economic circumstances, suggesting climate will likely exacerbate heat-related risks global health going forward.

Language: Английский

Citations

0

Investigation of the sustainability of breastfeeding and infant nutrition in the earthquake region based on mothers' experiences: a qualitative study DOI Creative Commons
Özge Karakaya Suzan, Sümeyra Topal, Sinem Yalnızoğlu Çaka

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 11, 2025

To explore the breastfeeding status of mothers with children aged 0–2 years after major earthquake disaster in Kahramanmaraş, to reveal obstacles sustainability breastfeeding, and problems experiences they have preparing formula, feeding their infants. This study used a qualitative, exploratory research design phenomenological approach. Data were collected between September November 2023 by face-to-face interviews using Personal Information Form semi-structured interview form. A total 21 participants who breastfed babies before experienced included study, which was conducted purposive sampling technique. methodologically analysed inductive coding thematic analysis procedures. Max Qualitative Analysis Analytics Pro2020 software code data. The results revealed four primary themes twenty-two subcategories. main were; (i) Expectations from Health Personnel, (ii) Suggestions Mothers, (iii) Difficulties Experienced (iv) Experiences Breastfeeding Infant Feeding. obtained this showed that had terms information, support, equipment, appropriate area, food supply related infant especially early post-disaster period. Insights into mothers' perspectives can help healthcare professionals understand challenges faced during disasters emergencies. In way, nurses take lead implementing programs designed support continued nutrition for disasters.

Language: Английский

Citations

0

Applying authoritative knowledge to better understand preparation for breastfeeding DOI Creative Commons
Margaret Butler, Sera L. Young, Lauren Keenan‐Devlin

et al.

Frontiers in Global Women s Health, Journal Year: 2025, Volume and Issue: 6

Published: March 31, 2025

In this qualitative study, we employ the construct of authoritative knowledge to better understand how birthing people prepare for breastfeeding experiences postpartum. This has seldom been applied postpartum period, despite its application by reproductive anthropologists pregnancy and childbirth cross-culturally. Consistent with these applications, define domains purveyors. We aimed characterize acquisition valuation information sources participants used breastfeeding. Twenty-five were recruited from a hospital-based study in Chicagoland, Illinois, USA complete interviews between November 2020 March 2021. Audio recorded coded using priori themes iterative code development. Codes designation three knowledge: biomedical, social network, lived experience. All received about both biomedical network domains, those prior child rearing also personal experience domain. Use online resources like tracking apps media platforms resulted overlapping. Participants valued health care providers most but found was more accessible fulfilled their desire experiential information. first within context infant feeding, consistently cited as accurate important. However, they barriers gaining such short duration prenatal appointments challenge completing education courses. Many sought evidence-based on apps, media, websites, however content quality across varies significantly. may be an avenue improve access reliable helpful

Language: Английский

Citations

0

The Climate Crisis and Breastfeeding: Opportunities for Resilience DOI
Elizabeth Cerceo, Karen Saxer,

Lauren Grossman

et al.

Journal of Human Lactation, Journal Year: 2023, Volume and Issue: 40(1), P. 33 - 50

Published: Dec. 29, 2023

The climate crisis is an emerging global challenge that poses potential risks to breastfeeding practices and outcomes. There are multifaceted effects of change affecting the dyad across environmental, societal, human health dimensions. Breastfeeding support in face will require solutions at structural level—healthcare, community, workplace settings—and mother-infant level. can additionally be adaptive response situations mitigate some environmental challenges associated with change. Despite undeniable significance on (and vice versa), our perspective as experts field this topic has not been systematically addressed. Although we highlight challenges, solutions, co-benefits context change, there numerous issues could further explored necessitate additional preparedness planning.

Language: Английский

Citations

9

The Association Between Prenatal Food Insecurity and Breastfeeding Initiation and Exclusive Breastfeeding Duration: A Longitudinal Study Using Oregon PRAMS and PRAMS-2, 2008–2015 DOI
Dane A. De Silva,

Elaine A. Anderson,

Jinhee Kim

et al.

Breastfeeding Medicine, Journal Year: 2024, Volume and Issue: 19(5), P. 368 - 377

Published: March 20, 2024

In the United States, 11.1% of households experience food insecurity; however, pregnant women are disproportionately affected. Maternal insecurity may affect infant feeding practices, for example, through being a source chronic stress that alter decision to initiate and continue breastfeeding. Thus, we sought determine whether prenatal was associated with breastfeeding (versus not) exclusive duration among Oregon women.

Language: Английский

Citations

2

The epidemiology and associated factors of non-exclusive breastfeeding: a comparative cross-sectional study of livelihood-secure and insecure areas DOI Creative Commons

Ayenew Negesse,

Tsinuel Girma, Beruk Berhanu Desalegn

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 17, 2024

Introduction Regardless of national commitment, non-exclusive breastfeeding (NEBF) is a public health problem that worsens over time. It can be associated with sociodemographic, economic, and environmental factors may vary depending on livelihood security. Hence, this study aimed to determine the magnitude NEBF identify its by considering two areas varied degrees Methods This represented comparative cross-sectional survey 1,060 under 6 months (u6m) infant–mother pairs. Both descriptive analytic statistics were evaluated using STATA version 17 packages. A binary logistic regression was used NEBF. The odds ratio (OR) 95% confidence interval (CI) measure significance association at p -value <0.05. Results pooled 51% mothers (95% CI: 48.0, 54.0) 53.1% 49.2, 57.0) 48.1% 43.4, 52.8) in livelihood-secure livelihood-insecure areas, respectively. lack recollecting infant’s birth date (AOR = 2.4; CI 1.15–4.40) had highest while household heads tertiary education 0.14; 0.01–0.54) poorest households 0.43; 95%CI 0.20–0.82) lowest but not areas. Moreover, male infants 1.9; 1.18–2.92) high Infants 2 less than 4-month-old 8.5; 3.47–18.63) 4 6-month-old 22.2; 8.02–51.97) 4.3; 1.29–11.67) 8.3; 2.44–22.39) Conclusion Over half practicing NEBF, which represents failure meet international targets. Area vulnerability security modifies Male insecure unknown age secure aged or older, regardless setting, more vulnerable However, wealth higher head educational status livelihood-based interventions targeting infants, emphasis these factors, help address reduce

Language: Английский

Citations

1

“A Vulnerable Time To Be a Young Family in an Emergency”: Qualitative Findings From an Exploration of an Emergency Perinatal and Infant Feeding Hotline in Louisiana DOI
Tyra Gross,

Malaika Ludman,

Alexis Woods Barr

et al.

Journal of Human Lactation, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Birthmark Doula Collective, a cooperative that provides doula and lactation services in the Greater New Orleans area, mounted an emergency response after two Category 4 storms: Hurricane Laura (2020) Ida (2021). The included activating no-cost perinatal infant feeding hotline. Both disasters coincided with resurgence of COVID-19 infections Louisiana.

Language: Английский

Citations

1

Health-Promoting Factors of Human Milk Across Lifespan DOI
Hajar Azraida, Abdelmounaim Baslam, Jawad Laadraoui

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 369 - 389

Published: June 14, 2024

Maternal milk intake during infancy is a fundamental aspect of child nutrition, with significant implications for long-term health outcomes. This chapter explores the importance breastfeeding and nutritional benefits breast optimal growth, immune function, cognitive development in infants. Despite established advantages, various challenges hinder initiation continuation rates, including inadequate support systems cultural barriers. Strategies promoting supporting breastfeeding, such as community education initiatives workplace accommodations, are discussed. By emphasizing critical role maternal intake, this aims to empower stakeholders advocate cornerstone health, ensuring best start life future generations.

Language: Английский

Citations

1