bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 15, 2023
Abstract
Human
infants
are
born
to
breastfeed.
While
50%
of
lactating
persons
struggle
make
enough
milk,
there
no
governmentally-approved
drugs
enhance
lactation
1
.
Here,
we
engineer
a
variant
the
naturally-occurring
driver
lactation,
hormone
Prolactin,
increase
its
serum
half-life
and
produce
viable
drug
candidate.
Our
engineered
variant,
Prolactin-eXtra
Long-acting
(Prolactin-XL),
is
comprised
endogenously
active
human
prolactin
fused
an
IgG
Fc
domain
designed
overcome
unique
development
challenges
specific
person-infant
dyad.
Prolactin-XL
has
70.9h
in
mice,
2,625-fold
longer
than
alone
(70.9h
v.
0.027h).
We
demonstrate
that
increases
milk
production
restores
growth
pups
fed
by
dams
with
pharmacologically-ablated
lactation.
show
Prolactin-XL-enhanced
accompanied
reversible,
lactocyte-driven
changes
mammary
gland
morphology.
This
work
establishes
long-acting
prolactins
as
potentially
powerful
pharmacologic
means
combat
insufficient
Maternal and Child Nutrition,
Journal Year:
2024,
Volume and Issue:
20(4)
Published: July 3, 2024
Abstract
Breastfeeding
offers
ideal
food
and
nutrition
for
infants;
however,
structural
barriers
may
amplify
breastfeeding
inequities.
We
aimed
to
identify
whether
household
insecurity
(HFI)
is
associated
with
exclusive
continued
(EBF
CBF)
as
recommended
by
the
World
Health
Organization/United
Nations
Children's
Fund
(UNICEF)
Following
Preferred
Reporting
Items
Systematic
Reviews
Meta‐Analysis,
literature
searches
using
‘breastfeeding’,
‘food
insecurity’
‘infant’
terms
were
conducted
in
PubMed/MEDLINE,
Embase,
CINAHL,
Global
LILACS
from
inception
through
November
2023,
without
language
restrictions,
yielding
1382
publications
(PROSPERO:CRD42022329836).
Predetermined
eligibility
criteria
yielded
12
included
studies
(nine
cross‐sectional
three
cohorts).
The
risk
of
bias
was
assessed
Effective
Public
Practice
Project.
Meta‐analysis
performed
assessing
EBF
(
n
=
10),
metaregression
used
explore
heterogeneity
across
studies.
Prevalence
ranged
1.6%
85.3%,
a
lower
prevalence
among
HFI.
pooled
effect
association
between
HFI
presented
an
odds
ratio
(OR)
0.61
(95%
CI
0.49–0.76)
consistent
results
marginal
(OR
0.72,
95%
0.55–0.94),
moderate
0.59,
0.41–0.84)
severe
0.49,
0.32–0.76).
High
found
only
when
dichotomized.
CBF
35.4%
78.0%,
inconsistent
HFI;
meta‐analysis
not
due
low
number
3).
concluded
that
levels
are
EBF.
Integrating
service
policy‐level
strategies,
such
screening,
referrals,
skilled
counseling
access
comprehensive
social
programs,
could
reduce
inequities
promote
adherence
Organization/UNICEF
recommendations
food‐insecure
families.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 22, 2025
Background
Ethiopia
has
had
a
long-standing
national
commitment
to
improving
child
health.
However,
evidence
on
trends
in
breastfeeding
remained
fragmented,
and
there
is
paucity
of
information
the
impacts
policy
breast
feeding
practices
associated
factors
influencing
it.
This
study
examined
determinants
exclusive
predominant
last
two
decades.
Methods
The
employed
retrospective
observational
design
using
Ethiopian
Demographic
Health
Surveys
(EDHS2000-2019)
dataset
for
children
aged
<6
months
their
mothers.
Data
analyses
were
performed
via
SPSS
version
25.
Trend
analysis
multivariable
logistic
regression
used.
Results
Exclusive
have
fluctuated
inconsistently
over
past
increased
from
59.96%
2000
66.01%
2016
then
decreased
59.86%
2019.
Predominant
40.04%
32.95%
39.43%
Regional
state,
place
residence,
religion
significantly
(
p
<
0.001)
with
likelihood
practicing
or
breastfeeding.
Conclusion
These
inconsistent
complex
interplay
various
suggest
limited
success
previous
policies
strategies
highlight
need
further
investigation
revisiting
current
more
nuanced
targeted
approach
future
interventions.
Annals of Human Biology,
Journal Year:
2025,
Volume and Issue:
52(1)
Published: Feb. 24, 2025
Climate
change
is
a
growing
threat
to
population
health,
with
dangerous
combinations
of
heat
and
humidity
increasing
in
frequency,
particularly
South
Asia.
Evidence
suggests
that
high
temperatures
stress
influence
breastfeeding
behaviour
may
lead
suboptimal
infant
young
child
nutrition.
Few
studies
have
quantified
the
relationship
between
ambient
breastfeeding.
Here
we
evaluate
associations
wet-bulb
temperature
daily
patterns
rural
community
Bangladesh.
We
used
23
months
time-diary
data
from
68
maternal-child
dyads
regional
test
hypothesis
increased
negatively
outcomes
among
Shodagor
fisher-traders.
found
higher
predicted
reduced
time
allocation,
fishers,
drove
shifts
towards
night-time
decreased
mid/late
morning
feeding.
Maternal
occupation
interaction
age
strongly
influenced
diurnal
patterns.
These
results
highlight
an
important
role
maternal
work
on
infants'
vulnerability
environmental
stress.
Dyads'
ability
behaviourally
compensate
for
extreme
be
constrained
by
extended
heatwaves,
humidity,
economic
circumstances,
suggesting
climate
will
likely
exacerbate
heat-related
risks
global
health
going
forward.
BMC Public Health,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 11, 2025
To
explore
the
breastfeeding
status
of
mothers
with
children
aged
0–2
years
after
major
earthquake
disaster
in
Kahramanmaraş,
to
reveal
obstacles
sustainability
breastfeeding,
and
problems
experiences
they
have
preparing
formula,
feeding
their
infants.
This
study
used
a
qualitative,
exploratory
research
design
phenomenological
approach.
Data
were
collected
between
September
November
2023
by
face-to-face
interviews
using
Personal
Information
Form
semi-structured
interview
form.
A
total
21
participants
who
breastfed
babies
before
experienced
included
study,
which
was
conducted
purposive
sampling
technique.
methodologically
analysed
inductive
coding
thematic
analysis
procedures.
Max
Qualitative
Analysis
Analytics
Pro2020
software
code
data.
The
results
revealed
four
primary
themes
twenty-two
subcategories.
main
were;
(i)
Expectations
from
Health
Personnel,
(ii)
Suggestions
Mothers,
(iii)
Difficulties
Experienced
(iv)
Experiences
Breastfeeding
Infant
Feeding.
obtained
this
showed
that
had
terms
information,
support,
equipment,
appropriate
area,
food
supply
related
infant
especially
early
post-disaster
period.
Insights
into
mothers'
perspectives
can
help
healthcare
professionals
understand
challenges
faced
during
disasters
emergencies.
In
way,
nurses
take
lead
implementing
programs
designed
support
continued
nutrition
for
disasters.
Frontiers in Global Women s Health,
Journal Year:
2025,
Volume and Issue:
6
Published: March 31, 2025
In
this
qualitative
study,
we
employ
the
construct
of
authoritative
knowledge
to
better
understand
how
birthing
people
prepare
for
breastfeeding
experiences
postpartum.
This
has
seldom
been
applied
postpartum
period,
despite
its
application
by
reproductive
anthropologists
pregnancy
and
childbirth
cross-culturally.
Consistent
with
these
applications,
define
domains
purveyors.
We
aimed
characterize
acquisition
valuation
information
sources
participants
used
breastfeeding.
Twenty-five
were
recruited
from
a
hospital-based
study
in
Chicagoland,
Illinois,
USA
complete
interviews
between
November
2020
March
2021.
Audio
recorded
coded
using
priori
themes
iterative
code
development.
Codes
designation
three
knowledge:
biomedical,
social
network,
lived
experience.
All
received
about
both
biomedical
network
domains,
those
prior
child
rearing
also
personal
experience
domain.
Use
online
resources
like
tracking
apps
media
platforms
resulted
overlapping.
Participants
valued
health
care
providers
most
but
found
was
more
accessible
fulfilled
their
desire
experiential
information.
first
within
context
infant
feeding,
consistently
cited
as
accurate
important.
However,
they
barriers
gaining
such
short
duration
prenatal
appointments
challenge
completing
education
courses.
Many
sought
evidence-based
on
apps,
media,
websites,
however
content
quality
across
varies
significantly.
may
be
an
avenue
improve
access
reliable
helpful
Journal of Human Lactation,
Journal Year:
2023,
Volume and Issue:
40(1), P. 33 - 50
Published: Dec. 29, 2023
The
climate
crisis
is
an
emerging
global
challenge
that
poses
potential
risks
to
breastfeeding
practices
and
outcomes.
There
are
multifaceted
effects
of
change
affecting
the
dyad
across
environmental,
societal,
human
health
dimensions.
Breastfeeding
support
in
face
will
require
solutions
at
structural
level—healthcare,
community,
workplace
settings—and
mother-infant
level.
can
additionally
be
adaptive
response
situations
mitigate
some
environmental
challenges
associated
with
change.
Despite
undeniable
significance
on
(and
vice
versa),
our
perspective
as
experts
field
this
topic
has
not
been
systematically
addressed.
Although
we
highlight
challenges,
solutions,
co-benefits
context
change,
there
numerous
issues
could
further
explored
necessitate
additional
preparedness
planning.
Breastfeeding Medicine,
Journal Year:
2024,
Volume and Issue:
19(5), P. 368 - 377
Published: March 20, 2024
In
the
United
States,
11.1%
of
households
experience
food
insecurity;
however,
pregnant
women
are
disproportionately
affected.
Maternal
insecurity
may
affect
infant
feeding
practices,
for
example,
through
being
a
source
chronic
stress
that
alter
decision
to
initiate
and
continue
breastfeeding.
Thus,
we
sought
determine
whether
prenatal
was
associated
with
breastfeeding
(versus
not)
exclusive
duration
among
Oregon
women.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: May 17, 2024
Introduction
Regardless
of
national
commitment,
non-exclusive
breastfeeding
(NEBF)
is
a
public
health
problem
that
worsens
over
time.
It
can
be
associated
with
sociodemographic,
economic,
and
environmental
factors
may
vary
depending
on
livelihood
security.
Hence,
this
study
aimed
to
determine
the
magnitude
NEBF
identify
its
by
considering
two
areas
varied
degrees
Methods
This
represented
comparative
cross-sectional
survey
1,060
under
6
months
(u6m)
infant–mother
pairs.
Both
descriptive
analytic
statistics
were
evaluated
using
STATA
version
17
packages.
A
binary
logistic
regression
was
used
NEBF.
The
odds
ratio
(OR)
95%
confidence
interval
(CI)
measure
significance
association
at
p
-value
<0.05.
Results
pooled
51%
mothers
(95%
CI:
48.0,
54.0)
53.1%
49.2,
57.0)
48.1%
43.4,
52.8)
in
livelihood-secure
livelihood-insecure
areas,
respectively.
lack
recollecting
infant’s
birth
date
(AOR
=
2.4;
CI
1.15–4.40)
had
highest
while
household
heads
tertiary
education
0.14;
0.01–0.54)
poorest
households
0.43;
95%CI
0.20–0.82)
lowest
but
not
areas.
Moreover,
male
infants
1.9;
1.18–2.92)
high
Infants
2
less
than
4-month-old
8.5;
3.47–18.63)
4
6-month-old
22.2;
8.02–51.97)
4.3;
1.29–11.67)
8.3;
2.44–22.39)
Conclusion
Over
half
practicing
NEBF,
which
represents
failure
meet
international
targets.
Area
vulnerability
security
modifies
Male
insecure
unknown
age
secure
aged
or
older,
regardless
setting,
more
vulnerable
However,
wealth
higher
head
educational
status
livelihood-based
interventions
targeting
infants,
emphasis
these
factors,
help
address
reduce
Journal of Human Lactation,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 29, 2024
Birthmark
Doula
Collective,
a
cooperative
that
provides
doula
and
lactation
services
in
the
Greater
New
Orleans
area,
mounted
an
emergency
response
after
two
Category
4
storms:
Hurricane
Laura
(2020)
Ida
(2021).
The
included
activating
no-cost
perinatal
infant
feeding
hotline.
Both
disasters
coincided
with
resurgence
of
COVID-19
infections
Louisiana.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 369 - 389
Published: June 14, 2024
Maternal
milk
intake
during
infancy
is
a
fundamental
aspect
of
child
nutrition,
with
significant
implications
for
long-term
health
outcomes.
This
chapter
explores
the
importance
breastfeeding
and
nutritional
benefits
breast
optimal
growth,
immune
function,
cognitive
development
in
infants.
Despite
established
advantages,
various
challenges
hinder
initiation
continuation
rates,
including
inadequate
support
systems
cultural
barriers.
Strategies
promoting
supporting
breastfeeding,
such
as
community
education
initiatives
workplace
accommodations,
are
discussed.
By
emphasizing
critical
role
maternal
intake,
this
aims
to
empower
stakeholders
advocate
cornerstone
health,
ensuring
best
start
life
future
generations.