Genomic Evolution of the SARS-CoV-2 Omicron Variant in Córdoba, Argentina (2021–2022): Analysis of Uncommon and Prevalent Spike Mutations

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1877 - 1877

Published: Dec. 3, 2024

Understanding the evolutionary patterns and geographic spread of SARS-CoV-2 variants, particularly Omicron, is essential for effective public health responses. This study focused on genomic analysis Omicron variant in Cordoba, Argentina from 2021 to 2022. Phylogenetic revealed dominant presence BA.1 BA.2 lineages, with BA.5 emerging earlier than BA.4, aligning observations other regions. Haplotype network showed significant genetic divergence within samples, forming distinct clusters. In comparison global datasets, we identified mutations genomes (A27S, Y145D, L212I) situated NTD region Spike protein. These mutations, while not widespread globally, higher prevalence our region. Of particular interest were Y145D L212I substitutions, previously unreported Argentina. silico that both impact binding affinity T-cell epitopes HLA type I II alleles. Notably, these alleles are among most common Argentinian population, some associated protection against others susceptibility infection. findings strongly suggest prevalent likely influence immunogenicity protein contribute immune evasion mechanisms. provides valuable insights into dynamics highlights unique potential implications COVID-19 vaccines.

Language: Английский

Leveraging wastewater-based epidemiology to monitor the spread of neglected tropical diseases in African communities

Infectious Diseases, Journal Year: 2024, Volume and Issue: 56(9), P. 697 - 711

Published: June 26, 2024

Neglected tropical diseases continue to cause a significant burden worldwide, with Africa accounting for more than one-third of the global burden. Over past decade, progress has been made in eliminating, controlling, and eradicating these Africa. By December 2022, 47 out 54 African countries had eliminated at least one neglected disease, were close achieving this milestone. Between 2020 2021, there was an 80 million reduction people requiring intervention. However, continued efforts are needed manage address their social economic burden, as they deepen marginalisation stigmatisation. Wastewater-based epidemiology involves analyzing wastewater detect quantify biomarkers disease-causing pathogens. This approach can complement current disease surveillance systems provide additional layer information monitoring spread detecting outbreaks. is particularly important due limited traditional methods. also provides tsunami-like warning system outbreaks facilitate timely intervention optimised resource allocation, providing unbiased reflection community's health compared systems. In review, we highlight potential wastewater-based innovative transmission within communities improving existing Our analysis shows that enhance Africa, early detection management Buruli ulcers, hookworm infections, ascariasis, schistosomiasis, dengue, chikungunya, echinococcosis, rabies, cysticercosis better control.

Language: Английский

Use of wastewater from passenger ships to assess the movement of COVID-19 and other pathogenic viruses across maritime international boundaries

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: July 15, 2024

The worldwide spread of SARS-CoV-2 and the resulting COVID-19 pandemic has been driven by international travel. This led to desire develop surveillance approaches which can estimate rate import pathogenic organisms across borders. aim this study was investigate use wastewater-based for viral pathogens on commercial short-haul (3.5 h transit time) roll-on/roll-off passenger/freight ferries operating between UK Republic Ireland.

Language: Английский