Risk of Severe Outcomes From COVID-19 in Comorbid Populations in the Omicron Era: A Meta-analysis DOI Creative Commons
Andrew R. Chapman,

Dan H. Barouch,

Gregory Y.H. Lip

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Importance This is the first meta-analysis to investigate risk of death and hospitalization in individuals with comorbidities, specifically during Omicron era. Objective To assess mortality from COVID-19 comorbidities comparison without Data Sources A systematic search Embase, MEDLINE, PubMed, Europe PMC, Latin American Caribbean Health Sciences Literature, Cochrane Study Register, WHO Database was performed identify studies published between 1 January 2022 13 March 2024. Selection Inclusion criteria were observational including people (all ages) at least following comorbidities: cardiovascular/ cerebrovascular disease, chronic lung conditions, diabetes, obesity. In total, 72 included review, which 68 meta-analyzed. Extraction Synthesis extracted by one reviewer verified a second. Studies synthesized quantitively (meta-analysis) using random-effect models. PRISMA guidelines followed. Main Outcomes Measures Evaluated outcomes risks death, hospitalization, intensive care unit (ICU) admission, any combination these outcomes. Odds ratios, hazard rate ratios extracted; pooled relative (RR) 95% confidence intervals (CI) calculated. Results Minimum numbers participants per comorbidity across ranged 328 870 for thrombosis 720 480 hypertension. Risks combined outcome increased COPD, respiratory diseases, heart failure versus those (pooled RRs 1.27 [heart hospitalization; CI, 1.17-1.38, P < .001] 1.78 failure, death: 1.46-2.16, .001]). Individuals diabetes obesity had ICU admission (RR: 1.20; CI: 1.04-1.38, = .0141 RR: 1.32; 1.11-1.57, .00158, respectively). Conclusions During era, amongst cerebrovascular/cardiovascular highest failure. are admission. Key Points Question What severe era? Findings review found among range without. Risk higher diabetes. Meaning study identified comorbid populations most COVID-19. Targeting public health measures, such as vaccination, may be beneficial.

Language: Английский

Pathogen distribution and infection patterns in pediatric severe pneumonia: A targeted next-generation sequencing study DOI
Jie Tan, Yan Chen, Jia Lu

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 119985 - 119985

Published: Oct. 1, 2024

Language: Английский

Citations

6
Antibiotic Utilization and Resistance According to the WHO AWaRe Classification in Intensive Care Units After COVID-19 Third Wave in Pakistan: Findings and Implications DOI Creative Commons

Muhammad Shahid Iqbal,

Mohd Faiyaz Khan,

Sadaf Farooqui

et al.

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 481 - 481

Published: March 10, 2025

Background and Objective: Irrational use overuse of antibiotics is considered a major cause antimicrobial resistance (AMR) among patients admitted to hospitals, especially in intensive care units (ICUs). ICUs are the most critical wards healthcare settings, where much higher compared other wards. Therefore, appropriate administration monitoring antibiotic usage these matter concern. Materials Methods: This retrospective study evaluated types, utilization patterns, sensitivity, various used different hospitals after third wave coronavirus disease 2019 (COVID-19) Pakistan. Results: It was observed that more than 40% were given two 54.3% at least one each day. A total 768 from groups, based on World Health Organization (WHO) Access, Watch, Reserve (AWaRe) classification, prescribed 313 between April August 2021. Among types antibiotics, amoxicillin/clavulanic acid frequently (75 prescriptions). also majority bacterial isolates sensitive carbapenems antibiotics. The current showed according AWaRe classifications 31.8% Access category, 59.5% Watch 8.7% category studied COVID-19. Conclusions: findings highlight importance continuous need for implementation stewardship programs optimize hospitals.

Language: Английский

Citations

0
Risk of Severe Outcomes From COVID-19 in Immunocompromised People During the Omicron Era: A Systematic Review and Meta-Analysis DOI Creative Commons
Andrew R. Chapman, Francis Bérenbaum, Giuseppe Curigliano

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Key Points Question: What are the risks of severe outcomes from COVID-19 in people with immunocompromising/immunosuppressive (IC/IS) conditions Omicron era? Findings: This systematic review and meta-analysis found increased risk for IC/IS (e.g., autoimmunity, cancer, liver disease, renal transplant) compared without respective conditions. Of all meta-analyzed conditions, transplant recipients had highest outcomes, non-transplant or general population. Meaning: People remain at during era; continued preventative measures personalized care crucial. Importance is first to investigate individuals specifically era. Objective To assess mortality hospitalization Data Sources A search Embase, MEDLINE, PubMed, Europe PMC, Latin American Caribbean Health Sciences Literature, Cochrane Study Register, WHO Database was performed identify studies published between 1 January 2022 13 March 2024. Selection Inclusion criteria were observational that included (all ages) least following conditions: unspecified groups, (solid organ, stem cells, bone marrow), any malignancy, autoimmune diseases, chronic end-stage kidney advanced/untreated HIV. In total, 72 review, which 66 meta-analysis. Extraction Synthesis extracted by one reviewer verified a second. Studies synthesized quantitively (meta-analysis) using random-effect models. PRISMA guidelines followed. Main Outcomes Measures Evaluated death, hospitalization, intensive unit (ICU) admission, combination these outcomes. Odds ratios, hazard rate ratios extracted; pooled relative (RR) 95% confidence intervals (CI) calculated. Results Minimum numbers participants per condition ranged 12 634 3 287 816. Risks death (RR, 6.78; CI, 4.41-10.43; P <.001), 6.75; 3.41-13.37; combined 8.65; 4.01-18.65; while group ICU admission 3.38; 2.37-4.83; <.001) Conclusions era, have substantially higher than

Language: Английский

Citations

0
Risk of Severe Outcomes From COVID-19 in Comorbid Populations in the Omicron Era: A Meta-analysis DOI Creative Commons
Andrew R. Chapman,

Dan H. Barouch,

Gregory Y.H. Lip

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Importance This is the first meta-analysis to investigate risk of death and hospitalization in individuals with comorbidities, specifically during Omicron era. Objective To assess mortality from COVID-19 comorbidities comparison without Data Sources A systematic search Embase, MEDLINE, PubMed, Europe PMC, Latin American Caribbean Health Sciences Literature, Cochrane Study Register, WHO Database was performed identify studies published between 1 January 2022 13 March 2024. Selection Inclusion criteria were observational including people (all ages) at least following comorbidities: cardiovascular/ cerebrovascular disease, chronic lung conditions, diabetes, obesity. In total, 72 included review, which 68 meta-analyzed. Extraction Synthesis extracted by one reviewer verified a second. Studies synthesized quantitively (meta-analysis) using random-effect models. PRISMA guidelines followed. Main Outcomes Measures Evaluated outcomes risks death, hospitalization, intensive care unit (ICU) admission, any combination these outcomes. Odds ratios, hazard rate ratios extracted; pooled relative (RR) 95% confidence intervals (CI) calculated. Results Minimum numbers participants per comorbidity across ranged 328 870 for thrombosis 720 480 hypertension. Risks combined outcome increased COPD, respiratory diseases, heart failure versus those (pooled RRs 1.27 [heart hospitalization; CI, 1.17-1.38, P < .001] 1.78 failure, death: 1.46-2.16, .001]). Individuals diabetes obesity had ICU admission (RR: 1.20; CI: 1.04-1.38, = .0141 RR: 1.32; 1.11-1.57, .00158, respectively). Conclusions During era, amongst cerebrovascular/cardiovascular highest failure. are admission. Key Points Question What severe era? Findings review found among range without. Risk higher diabetes. Meaning study identified comorbid populations most COVID-19. Targeting public health measures, such as vaccination, may be beneficial.

Language: Английский

Citations

0