The burden of neonatal sepsis and its risk factors in Africa. a systematic review and meta-analysis

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 3, 2025

Neonatal sepsis is a significant cause of newborn mortality in low- and middle-income countries (LMICs). Together, infections, complications preterm birth, intrapartum-related conditions contribute to nearly 90% all neonatal deaths. Africa experiences high rates deaths due sepsis, with insufficient prevention efforts. Understanding the burden essential reducing these region. This study aims estimate pooled magnitude identify its associated risk factors Africa. For this study, we gathered data by searching various databases until August 20, 2024, including PubMed/MEDLINE, PubMed Central, Hinari, Google, Cochrane Library, African Journals Online, Web Science, Google Scholar. Full-text articles English, both published unpublished, from 2000 2024 were included. However, sources like citations without abstracts or full texts, unidentified reports, editorials, summaries research, meta-analyses, qualitative studies not included study. We evaluated quality selected papers using Joanna Briggs Institute (JBI) critical appraisal checklist for observational studies. Data extraction was completed Microsoft Excel, analysis conducted STATA V.17 Statistical Software. assessed heterogeneity I2 statistic Q test. Publication bias visually through funnel plot statistically Egger's regression Begg's tests. Subgroup analyses performed heterogeneity, sensitivity find any outlier review includes 49 87,548 neonates. The overall found be 40.98% (95% confidence interval (CI): 30.50% 51.46%) P: 0.00. that such as prolonged rupture membranes (Odds ratio (OR) 4.11, 95% CI: 2.81–5.41) 0.00, history urinary tract sexually transmitted infections (OR 3.28, 1.97–4.58) low birth weight (< 2500 g) 6.95, 3–10.89) an Appearance, Pulse, Grimace, Activity, Respiration (APGAR) score below 7 at first minute 7.56, 3.39–11.73) 5.38, 3.23–7.5) neonates who resuscitated 3.26, 1.96–4.56) remains high. identified several contributing factors, membranes, g), APGAR one minute, resuscitation birth. These findings underscore importance routinely screening membrane maternal infections. Enhancing antenatal care, training providers early management, enforcing infection control measures.

Language: Английский

Neonatal Sepsis: Aetiology, Pathophysiology, Diagnostic Advances and Management Strategies

Clinical Medicine Insights Pediatrics, Journal Year: 2024, Volume and Issue: 18

Published: Jan. 1, 2024

Neonatal sepsis, a bloodstream infection in the first 28 days of life, is leading cause morbidity and mortality among infants both developing developed countries. Additionally, sepsis distinguished neonates by unique pathophysiological presentational factors relating to its development immature neonatal immune systems. This review focuses on current understanding mechanics implications providing comprehensive overview epidemiology, aetiology, pathophysiology, major risk factors, signs symptoms recent consensus diagnosis management early-onset late-onset sepsis. It also includes discussion novel biomarkers upcoming treatment strategies for condition as well potential COVID-19 progress infants.

Language: Английский

Utilizing Predictive Factors as a Screening Tool for Early-Onset Sepsis in Neonates

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Neonatal early-onset sepsis (EOS) is a severe condition that affects newborns within the first three days of life, with high mortality rates, particularly in low- and middle-income countries (LMICs). In Vietnam, diagnosis management EOS are challenged by ambiguous clinical signs limited access to blood culture testing facilities. Early identification at-risk neonates using predictive risk factor model crucial for improving neonatal care reducing mortality.

Language: Английский